{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:55:01Z","timestamp":1790654101331,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the adjunctive effect of locally delivered metronidazole\u2013minocycline (Met\/Mc) versus minocycline (Mc) ointment and mechanical debridement alone in non\u2010surgical treatment of peri\u2010implantitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Peri\u2010implantitis was induced through ligature in a canine model. Implants were allocated to mechanical debridement (control), Mc or Met\/Mc. Probing depth (PD), bleeding on probing (BOP), marginal bone levels (MBLs) and immunohistochemical parameters (CD3, CD20, IgG) were assessed over 12\u2009weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both Met\/Mc and Mc showed significantly greater PD reductions than control (\u0394 \u22125.33\u2009\u00b1\u20091.35\u2009mm and \u22123.67\u2009\u00b1\u20091.89\u2009mm vs. \u22120.04\u2009\u00b1\u20091.80\u2009mm;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0004). BOP and MBL reductions were significantly greater in Met\/Mc than Mc and control (BOP: \u0394 \u22125.67\u2009\u00b1\u20090.71 vs. \u22123.22\u2009\u00b1\u20092.54 vs. \u22120.78\u2009\u00b1\u20091.99,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.020; MBL: \u0394 \u22122.41\u2009\u00b1\u20091.21 vs. \u22120.80\u2009\u00b1\u20090.21 vs. +0.64\u2009\u00b1\u20090.93\u2009mm,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0035). Met\/Mc showed significantly lower CD3, CD20 and IgG than the control and lower CD20 and IgG than Mc (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this preclinical model, adjunctive Met\/Mc ointment yielded greater clinical and radiographic improvements than both comparators, accompanied by reduced B\u2010cell and plasma\u2010cell infiltration. These findings provide preclinical proof of concept, however, warranting clinical confirmation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.70203","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:55:09Z","timestamp":1790650509000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Local Application of a Combined Metronidazole and Minocycline Ointment in the Non\u2010Surgical Treatment of Peri\u2010Implantitis: A Preclinical In\u00a0Vivo Study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6408-1618","authenticated-orcid":false,"given":"Jin\u2010Young","family":"Park","sequence":"first","affiliation":[{"name":"Department of Periodontology, Research Institute for Periodontal Regeneration Yonsei University College of Dentistry  Seoul South 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