{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T06:44:39Z","timestamp":1791787479253,"version":"4.3.4"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>To investigate the effect of periodontal treatment on periodontal inflammation and periostin levels in patients with severe periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study included two groups (periodontitis and periodontally healthy), each comprising 24 individuals. Periodontal clinical parameters were recorded, and serum samples were collected at baseline and on Days 30 and 90 following non\u2010surgical periodontal treatment (NSPT). Gingival crevicular fluid (GCF) samples were collected at baseline and on Days 1, 2, 14, 30 and 90 following NSPT. Periostin, interleukin\u20101 beta (IL\u20101\u03b2) and fibroblast growth factor\u20102 (FGF\u20102) levels were assessed in serum and GCF samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Clinical periodontal parameters decreased from baseline to Days 30 and 90 after NSPT (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). Patients with periodontitis had higher levels of IL\u20101\u03b2 in serum (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.020) and GCF (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) than healthy individuals. Following periodontal treatment, serum IL\u20101\u03b2 levels decreased at Days 30 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.036) and 90 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.025) while GCF IL\u20101\u03b2 levels showed a reduction at Day 14 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). Periostin levels in GCF in patients with periodontitis were lower than in healthy individuals at baseline (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). It increased after treatment, reaching peak values on Day 14 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), followed by a gradual decrease on Days 30 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007) and 90 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). Levels of FGF\u20102 in GCF increased after periodontal treatment compared with baseline in patients with periodontitis, reaching peak levels on Day 2 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). Following periodontal treatment, periostin and FGF\u20102 levels remained higher in the periodontitis group than in the healthy group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), whereas IL\u20101\u03b2 levels decreased to levels comparable to those of the healthy group by Day 30 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2265\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In parallel with the reduction in periodontal tissue inflammation and IL\u20101\u03b2, periostin levels in GCF increased in response to periodontal treatment, suggesting its involvement in tissue healing in patients with periodontitis.<\/jats:p>\n                  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