{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:45:40Z","timestamp":1791765940823,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102026\u201025469650"],"award-info":[{"award-number":["RS\u20102026\u201025469650"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To histologically assess the effect of the timing of soft\u2010tissue augmentation (prior to or simultaneously with implant placement) and the type of grafting material on peri\u2010implant soft\u2010tissue dimensions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Mandibular molars (M1, M2, M3) were bilaterally extracted in six beagle dogs. Eight weeks after extraction, one mandibular side received primary soft\u2010tissue augmentation with an autogenous subepithelial connective tissue graft (SCTG) or a collagen\u2010based graft substitute (CG x1D), or no augmentation. At Week 16, implants were placed at these sites without flap. On the contralateral side, implants were placed with flap elevation simultaneously with SCTG or CG x1D, or no augmentation. Animals were sacrificed at Week 36. Histometric outcomes were analysed using linear mixed\u2010effects models with dog as a random intercept; significant six\u2010group effects were followed by Tukey\u2010adjusted pairwise comparisons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All six groups showed crestal bone remodelling apical to the implant shoulder. The AFL group consistently exhibited the greatest peri\u2010implant soft\u2010tissue dimensions. Significant overall group effects were identified for lingual fBIC\u2010M (\n                      <jats:italic>F<\/jats:italic>\n                      \u2009=\u20093.58,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014) and lingual IS\u2010M (\n                      <jats:italic>F<\/jats:italic>\n                      \u2009=\u20094.46,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005), with AFL significantly exceeding FL and FC at both outcomes. SCTG sites showed significantly greater lingual fBIC\u2010M and IS\u2010M than collagen substitute sites (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Prior soft\u2010tissue augmentation with an autogenous graft before flapless implant placement (AFL) resulted in more favourable peri\u2010implant soft\u2010tissue dimensions. Both autogenous grafts and collagen substitutes contribute to soft\u2010tissue volume gains around implants. Clinical trials are warranted to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.70211","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:05:28Z","timestamp":1791763528000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Crestal Soft\u2010Tissue Augmentation Prior to or Simultaneously With Implant Placement on Peri\u2010Implant Tissue Dimensions: Histological Outcomes of an Experimental In\u00a0Vivo Study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0701-3771","authenticated-orcid":false,"given":"Yifan","family":"Zhang","sequence":"first","affiliation":[{"name":"Sanya Stomatology Center (Peking University Hospital of Stomatology Sanya Division)  Sanya China"},{"name":"Department of Implantology Peking University School and Hospital of Stomatology &amp; National Center of Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices  Beijing China"},{"name":"Clinic of Reconstructive Dentistry, Center of Dental Medicine University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6543-2589","authenticated-orcid":false,"given":"Seo Young","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Periodontology Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1276-5978","authenticated-orcid":false,"given":"Seung Ha","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Periodontology Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry  Seoul 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College of Dentistry  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1764-7447","authenticated-orcid":false,"given":"Daniel S.","family":"Thoma","sequence":"additional","affiliation":[{"name":"Clinic of Reconstructive Dentistry, Center of Dental Medicine University of Zurich  Zurich Switzerland"},{"name":"Department of Periodontology Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry  Seoul 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