{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:49:27Z","timestamp":1791946167377,"version":"4.3.4"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,12,30]],"date-time":"2013-12-30T00:00:00Z","timestamp":1388361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000025","name":"NIMH","doi-asserted-by":"crossref","award":["MH060952"],"award-info":[{"award-number":["MH060952"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Child Psychology Psychiatry"],"published-print":{"date-parts":[[2014,2]]},"abstract":"\n Background<\/jats:title>\n \n The purpose of this study is to compare the dimensional psychopathology, as ascertained by parental report, in preschool offspring of parents with bipolar disorder (\n BP<\/jats:styled-content>\n ) and offspring of community control parents.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n 122 preschool offspring (mean age 3.3\u00a0years) of 84 parents with\n BP<\/jats:styled-content>\n , with 102 offspring of 65 control parents (36 healthy, 29 with non\u2010\n BP<\/jats:styled-content>\n psychopathology), were evaluated using the Child Behavior Checklist (\n CBCL<\/jats:styled-content>\n ), the\n CBCL<\/jats:styled-content>\n \u2010Dysregulation Profile (\n CBCL<\/jats:styled-content>\n \u2010\n DP<\/jats:styled-content>\n ), the Early Childhood Inventory (\n ECI<\/jats:styled-content>\n \u20104), and the Emotionality Activity Sociability (\n EAS<\/jats:styled-content>\n ) survey. Teachers' Report Forms (\n TRF<\/jats:styled-content>\n ) were available for 51 preschoolers.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n After adjusting for confounders, offspring of parents with\n BP<\/jats:styled-content>\n showed higher scores in the\n CBCL<\/jats:styled-content>\n total, externalizing, somatic, sleep, aggressive, and\n CBCL<\/jats:styled-content>\n \u2010\n DP<\/jats:styled-content>\n subscales; the\n ECI<\/jats:styled-content>\n \u20104 sleep problem scale; and the\n EAS<\/jats:styled-content>\n total and emotionality scale. The proportion of offspring with\n CBCL<\/jats:styled-content>\n T\u2010scores \u22652\n \n SD<\/jats:styled-content>\n <\/jats:italic>\n above the norm was significantly higher on most\n CBCL<\/jats:styled-content>\n subscales and the\n CBCL<\/jats:styled-content>\n \u2010\n DP<\/jats:styled-content>\n in offspring of parents with\n BP<\/jats:styled-content>\n compared to offspring of controls even after excluding offspring with attention deficit hyperactivity disorder and\/or oppositional defiant disorder. Compared to offspring of parents with\n BP<\/jats:styled-content>\n \u2010I, offspring of parents with\n BP<\/jats:styled-content>\n \u2010\n II<\/jats:styled-content>\n showed significantly higher scores in total and most\n CBCL<\/jats:styled-content>\n subscales, the\n ECI<\/jats:styled-content>\n \u20104 anxiety and sleep scales and the\n EAS<\/jats:styled-content>\n emotionality scale. For both groups of parents, there were significant correlations between\n CBCL<\/jats:styled-content>\n and\n TRF<\/jats:styled-content>\n scores (\n r<\/jats:italic>\n \u00a0=\u00a0.32\u2013.38,\n p<\/jats:italic>\n \u2010values \u2264.02).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Independent of categorical axis\u2010I psychopathology and other demographic or clinical factors in both biological parents, preschool offspring of parents with\n BP<\/jats:styled-content>\n have significantly greater aggression, mood dysregulation, sleep disturbances, and somatic complaints compared to offspring of control parents. Interventions to target these symptoms are warranted.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jcpp.12137","type":"journal-article","created":{"date-parts":[[2013,12,30]],"date-time":"2013-12-30T05:02:43Z","timestamp":1388379763000},"page":"144-153","source":"Crossref","is-referenced-by-count":43,"title":["Dimensional psychopathology in preschool offspring of parents with bipolar disorder"],"prefix":"10.1111","volume":"55","author":[{"given":"Hagai","family":"Maoz","sequence":"first","affiliation":[{"name":"Department of Psychiatry Western Psychiatric Institute and Clinic University of Pittsburgh School of Medicine Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Western Psychiatric Institute and Clinic University of Pittsburgh School of Medicine Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Axelson","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Western Psychiatric Institute and Clinic University of Pittsburgh School of Medicine Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin I.","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Sunnybrook Health Sciences Centre University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieyu","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Western Psychiatric Institute and Clinic University of Pittsburgh School of Medicine Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Beth","family":"Hickey","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Western Psychiatric Institute and Clinic University of Pittsburgh School of Medicine Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Monk","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Western Psychiatric Institute and Clinic University of Pittsburgh School of Medicine Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dara","family":"Sakolsky","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Western Psychiatric Institute and Clinic University of Pittsburgh School of Medicine Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasim S.","family":"Diler","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Western Psychiatric Institute and Clinic University of Pittsburgh School of Medicine Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Brent","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Western Psychiatric Institute and Clinic University of Pittsburgh School of Medicine Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish","family":"Iyengar","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Western Psychiatric Institute and Clinic University of Pittsburgh School of Medicine Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Kupfer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Western Psychiatric Institute and Clinic University of Pittsburgh School of Medicine Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Birmaher","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Western Psychiatric Institute and Clinic University of Pittsburgh School of Medicine Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,30]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Manual for the Achenbach System of Empirically Based Assessment Preschool Forms and Profiles","author":"Achenbach T. 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