{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:01:09Z","timestamp":1765544469638,"version":"build-2065373602"},"reference-count":54,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Sophia Foundation for Scientific Research","award":["547"],"award-info":[{"award-number":["547"]}]},{"name":"the Netherlands Organization for Scientific Research","award":["VIDI 017.106.370","VICI 453.09.003"],"award-info":[{"award-number":["VIDI 017.106.370","VICI 453.09.003"]}]},{"name":"Erasmus Medical Centre"},{"DOI":"10.13039\/501100001828","name":"Erasmus University Rotterdam","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001828","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001826","name":"the Netherlands Organization for Health Research and Development","doi-asserted-by":"crossref","award":["10.000.1003"],"award-info":[{"award-number":["10.000.1003"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Rotterdam Homecare Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Child Psychology Psychiatry"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Little is known about the genetic determinants of sensitive parenting. Two earlier studies examined the effect of the serotonin transporter polymorphism (5\u2010\n                      <jats:styled-content style=\"fixed-case\">HTTLPR<\/jats:styled-content>\n                      ) on sensitive parenting, but reported opposite results. In a large cohort we further examined whether 5\u2010\n                      <jats:styled-content style=\"fixed-case\">HTTLPR<\/jats:styled-content>\n                      is a predictor of observed maternal sensitivity and whether observed child social fearfulness moderates the effect of 5\u2010\n                      <jats:styled-content style=\"fixed-case\">HTTLPR<\/jats:styled-content>\n                      on maternal sensitivity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The population\u2010based cohort consisted of 767 mother\u2013child dyads. Maternal sensitivity was repeatedly observed at the child's age of 14\u00a0months, 36\u00a0months and 48\u00a0months. Sensitivity was coded using the Ainsworth's rating scales for sensitivity and cooperation and the revised Erickson rating scales for Supportive presence and Intrusiveness. Child social fearfulness was observed using the Stranger Approach episode of the Laboratory Temperament Assessment Battery at 36\u00a0months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Repeated measurement analyses showed a consistent main effect of maternal 5\u2010\n                      <jats:styled-content style=\"fixed-case\">HTTLPR<\/jats:styled-content>\n                      on sensitivity; mothers carrying the\n                      <jats:italic>S<\/jats:italic>\n                      \u2010allele were more sensitive toward their children (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.005). This effect was not explained by the child's 5\u2010\n                      <jats:styled-content style=\"fixed-case\">HTTLPR<\/jats:styled-content>\n                      genotype. We found no evidence that child social fearfulness moderated the effect of 5\u2010\n                      <jats:styled-content style=\"fixed-case\">HTTLPR<\/jats:styled-content>\n                      on sensitivity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study suggests that variations in maternal 5\u2010\n                      <jats:styled-content style=\"fixed-case\">HTTLPR<\/jats:styled-content>\n                      genotype appear to be involved in the etiology of parenting behavior. The observed effects of this genetic variation are consistent with the notion that parenting may have a genetic component, but large studies are needed to find the specific small molecular effects.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpp.12205","type":"journal-article","created":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T01:49:09Z","timestamp":1391219349000},"page":"1025-1032","source":"Crossref","is-referenced-by-count":25,"title":["Variations in maternal 5\u2010\n                    <scp>HTTLPR<\/scp>\n                    affect observed sensitive parenting"],"prefix":"10.1111","volume":"55","author":[{"given":"Rolieke A. M.","family":"Cents","sequence":"first","affiliation":[{"name":"The Generation R Study Group Erasmus MC\u2010University Medical Centre Rotterdam The Netherlands"},{"name":"Department of Child and Adolescent Psychiatry\/Psychology Erasmus MC\u2010University Medical Centre Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rianne","family":"Kok","sequence":"additional","affiliation":[{"name":"The Generation R Study Group Erasmus MC\u2010University Medical Centre Rotterdam The Netherlands"},{"name":"Department of Child and Adolescent Psychiatry\/Psychology Erasmus MC\u2010University Medical Centre Rotterdam The Netherlands"},{"name":"Centre for Child and Family Studies Leiden University Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henning","family":"Tiemeier","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry\/Psychology Erasmus MC\u2010University Medical Centre Rotterdam The Netherlands"},{"name":"Department of Epidemiology Erasmus MC\u2010University Medical Centre Rotterdam The Netherlands"},{"name":"Department of Psychiatry Erasmus MC\u2010University Medical Centre Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Lucassen","sequence":"additional","affiliation":[{"name":"The Generation R Study Group Erasmus MC\u2010University Medical Centre Rotterdam The Netherlands"},{"name":"Department of Child and Adolescent Psychiatry\/Psychology Erasmus MC\u2010University Medical Centre Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eszter","family":"Sz\u00e9kely","sequence":"additional","affiliation":[{"name":"The Generation R Study Group Erasmus MC\u2010University Medical Centre Rotterdam The Netherlands"},{"name":"Department of Child and Adolescent Psychiatry\/Psychology Erasmus MC\u2010University Medical Centre Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marian J.","family":"Bakermans\u2010Kranenburg","sequence":"additional","affiliation":[{"name":"Centre for Child and Family Studies Leiden University Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Hofman","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Erasmus MC\u2010University Medical Centre Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent W.V.","family":"Jaddoe","sequence":"additional","affiliation":[{"name":"The Generation R Study Group Erasmus MC\u2010University Medical Centre Rotterdam The Netherlands"},{"name":"Department of Epidemiology Erasmus MC\u2010University Medical Centre Rotterdam The Netherlands"},{"name":"Department of Pediatrics Erasmus MC\u2010University Medical Centre Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marinus H.","family":"van IJzendoorn","sequence":"additional","affiliation":[{"name":"Centre for Child and Family Studies Leiden University Leiden The Netherlands"},{"name":"School of Pedagogical and Educational Sciences Erasmus University Rotterdam Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank C.","family":"Verhulst","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry\/Psychology Erasmus MC\u2010University Medical Centre Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mijke P.","family":"Lambregtse \u2010van den Berg","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry\/Psychology Erasmus MC\u2010University Medical Centre Rotterdam The Netherlands"},{"name":"Department of Psychiatry Erasmus MC\u2010University Medical Centre Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"99","volume-title":"The introduction of the child into a social world","author":"Ainsworth M.D.S.","year":"1974"},{"volume-title":"Patterns of attachment. 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