{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:08:40Z","timestamp":1788862120976,"version":"build-2803163510"},"reference-count":70,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,6,25]],"date-time":"2014-06-25T00:00:00Z","timestamp":1403654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Faculty of Medicine, University of Munich"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Child Psychology Psychiatry"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Recent studies have proposed the process of emotion regulation as a promising target to study the neurophysiological basis of adolescent depression. Emotion regulation has repeatedly been studied with emotional go\/no\u2010go paradigms. To date, no study has examined if the left\u2010frontal hypoactivation associated with depression generalizes to active tasks. The aim of this study was therefore to investigate the hemispheric asymmetry of the N2 component in depressed adolescents in an emotion regulation paradigm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010four adolescents diagnosed with major depression (age 11\u201318) and 30 healthy controls (age 11\u201318) performed two emotional go\/no\u2010go tasks exhibiting negative faces as go trials and positive faces as no\u2010go trials and vice versa.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>On the behavioral level, no significant group differences emerged. On the neural level, we found a more right\u2010lateralized N2\u2010amplitude in depressed subjects, while it was more left\u2010lateralized in controls. Furthermore, both groups showed a less negative N2\u2010amplitude to positive no\u2010go stimuli.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study provides strong support for a general left\u2010frontal hypoactivity in adolescent depression, which also applies to active emotional go\/no\u2010go paradigms. Furthermore, the less negative N2 to positive stimuli is consistent with a generally enhanced impulsivity of adolescents toward appetitive stimuli, which is possibly the base of the differential clinical pattern of adolescent in contrast to adult depression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpp.12282","type":"journal-article","created":{"date-parts":[[2014,6,25]],"date-time":"2014-06-25T07:07:56Z","timestamp":1403680076000},"page":"76-86","source":"Crossref","is-referenced-by-count":22,"title":["Right\u2010lateralization of N2\u2010amplitudes in depressive adolescents: an emotional go\/no\u2010go study"],"prefix":"10.1111","volume":"56","author":[{"given":"Monika","family":"Trinkl","sequence":"first","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy Ludwig\u2010Maximilian University Munich 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Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy Ludwig\u2010Maximilian University Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Grossheinrich","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy Ludwig\u2010Maximilian University Munich Germany"},{"name":"Child Neuropsychology Section Department of Child and Adolescent Psychiatry Psychosomatics and Psychotherapy University Hospital RWTH Aachen Aachen Germany"},{"name":"Translational Brain Medicine in Psychiatry and Neurology Department of Child and Adolescent Psychiatry Psychosomatics, and Psychotherapy University Hospital RWTH Aachen \/ JARA Brain Translational Medicine Aachen and J\u00fclich 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