{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T10:21:06Z","timestamp":1768645266608,"version":"3.49.0"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,9,26]],"date-time":"2014-09-26T00:00:00Z","timestamp":1411689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Carlos III spanish ministry of health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Child Psychology Psychiatry"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The affective dimension has scarcely been studied in early\u2010onset psychosis. Our aims were to investigate the prevalence and type of affective symptoms in the prodromal and acute phases of early\u2010onset psychosis and to examine their relationship with suicide. We also sought to establish whether the presence of premorbid antecedents or the presence of affective symptoms during the prodromal and acute phase might predict a later diagnosis of bipolar disorder (\n                      <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n                      ) or schizophrenia (\n                      <jats:styled-content style=\"fixed-case\">SZ<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      Participants were 95 youths, aged 9\u201317\u00a0years, experiencing a first episode of a psychotic disorder (\n                      <jats:styled-content style=\"fixed-case\">FEP<\/jats:styled-content>\n                      ) according to\n                      <jats:styled-content style=\"fixed-case\">DSM<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\n                      criteria. Prodromal affective symptoms in the year prior to the onset of full\u2010blown psychosis were assessed by means of the K\u2010\n                      <jats:styled-content style=\"fixed-case\">SADS<\/jats:styled-content>\n                      . Affective symptoms during the acute episode were evaluated using the Hamilton Depression Rating Scale and the Young Mania Rating Scale. Suicidality was assessed during the acute episode and at 6 and 12\u00a0months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Half of the patients experienced affective symptoms during the prodrome, with depressive symptoms being the most frequently reported. During the acute episode, 23.2% presented depressive, 41.4% mixed and 18.9% manic symptoms. After logistic regression analysis, only the presence of depressive symptoms was significantly associated with suicidality during the 12\u00a0months following the\n                      <jats:styled-content style=\"fixed-case\">FEP<\/jats:styled-content>\n                      . Neither early premorbid antecedents nor the prevalence or type of affective symptoms during the\n                      <jats:styled-content style=\"fixed-case\">FEP<\/jats:styled-content>\n                      predicted a diagnosis of\n                      <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n                      or\n                      <jats:styled-content style=\"fixed-case\">SZ<\/jats:styled-content>\n                      at 12\u00a0months. However, both depressive and manic prodromal symptoms were associated with a later diagnosis of\n                      <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:styled-content style=\"fixed-case\">FEP<\/jats:styled-content>\n                      of both\n                      <jats:styled-content style=\"fixed-case\">SZ<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n                      is preceded by an identifiable prodromal phase. Early detection programs should target young people at clinical risk for the extended psychosis phenotype. The high prevalence of affective symptoms during the early phases of psychosis may encourage clinicians to identify and treat them in order to prevent suicide behaviour.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpp.12332","type":"journal-article","created":{"date-parts":[[2014,9,26]],"date-time":"2014-09-26T06:17:05Z","timestamp":1411712225000},"page":"747-755","source":"Crossref","is-referenced-by-count":32,"title":["The affective dimension of early\u2010onset psychosis and its relationship with suicide"],"prefix":"10.1111","volume":"56","author":[{"given":"Vanessa","family":"Sanchez\u2010Gistau","sequence":"first","affiliation":[{"name":"Department of Child and Adolescent Psychiatry and Psychology Hospital Clinic of Barcelona, Institute Clinic of Neurosciences University of Barcelona Barcelona 2009\u2010SGR\u20101119 Generalitat de Catalunya Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Salud Mental (CIBERSAM) Madrid Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inmaculada","family":"Baeza","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry and Psychology Hospital Clinic of Barcelona, Institute Clinic of Neurosciences University of Barcelona Barcelona 2009\u2010SGR\u20101119 Generalitat de Catalunya Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Salud Mental (CIBERSAM) Madrid Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celso","family":"Arango","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Salud Mental (CIBERSAM) Madrid Spain"},{"name":"Adolescent Unit Department of Psychiatry Hospital General Universitario Gregorio Mara\u00f1\u00f3n Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Gonz\u00e1lez\u2010Pinto","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Salud Mental (CIBERSAM) Madrid Spain"},{"name":"Department of Psychiatry Hospital Santiago Ap\u00f3stol EHU\/University of the Basque Country Vitoria Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"de la Serna","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Salud Mental (CIBERSAM) Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mara","family":"Parellada","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Salud Mental (CIBERSAM) Madrid Spain"},{"name":"Adolescent Unit Department of Psychiatry Hospital General Universitario Gregorio Mara\u00f1\u00f3n Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montserrat","family":"Graell","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry and Psychology Hospital Infantil Universitario Ni\u00f1o Jes\u00fas Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Paya","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Salud Mental (CIBERSAM) Madrid Spain"},{"name":"Child and Adolescent Mental Health Unit Department of Psychiatry and Psychology Hospital Universitario Marqu\u00e9s de Valdecilla Santander Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cloe","family":"Llorente","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Salud Mental (CIBERSAM) Madrid Spain"},{"name":"Adolescent Unit Department of Psychiatry Hospital General Universitario Gregorio Mara\u00f1\u00f3n Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josefina","family":"Castro\u2010Fornieles","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry and Psychology Hospital Clinic of Barcelona, Institute Clinic of Neurosciences University of Barcelona Barcelona 2009\u2010SGR\u20101119 Generalitat de Catalunya Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Salud Mental (CIBERSAM) Madrid Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2010.10.011"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbt198"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2010.03.012"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2013.04.027"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161212799316226"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.182.5.373"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.178.5.420"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2011.02443.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2006.12.004"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2008.00610.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2009.12.021"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.schbul.a007036"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbm028"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291709990651"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2009.10.027"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.157"},{"key":"e_1_2_7_19_1","first-page":"107","article-title":"The psychosis high\u2010risk state: A comprehensive state\u2010of\u2010the\u2010art review","volume":"70","author":"Fusar\u2010Poli P.","year":"2013","journal-title":"Journal of the American Medical Association Psychiatry"},{"key":"e_1_2_7_20_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1001\/archgenpsychiatry.2012.650","article-title":"Predictors of Prospectively Examined Suicide Attempts Among Youth With Bipolar DisorderPredictors of Suicide Attempts","volume":"69","author":"Goldstein T.R.","year":"2012","journal-title":"Archives of General Psychiatry"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2004.04.019"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00014180"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2005.01.004"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8260.1967.tb00530.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.97.10.1756"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.182.1.37"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199707000-00021"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2011.09.005"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(02)00335-3"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2012.01.004"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2008.133"},{"key":"e_1_2_7_32_1","first-page":"171","article-title":"Validaci\u00f3n de la escala de los s\u00edndromes positivo y negativo (PANSS) en una muestra de esquizofr\u00e9nicos espa\u00f1oles","volume":"22","author":"Peralta V.","year":"1994","journal-title":"Actas Luso Espa\u00f1olas Neurolog\u00eda y Psiquiatr\u00eda"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2009.03.008"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2011.03.008"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2007.164.7.1035"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08185"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2010.10.003"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1159\/000338548"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/NMD.0b013e3181c81fc0"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2006.04.008"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.12m07632"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1983.01790100074010"},{"key":"e_1_2_7_43_1","first-page":"131","article-title":"Clinical Phenotypes of Psychosis in the Bipolar and Schizophrenia Network on Intermediate Phenotypes (B\u2010SNIP)","volume":"40","author":"Tamminga C.A.","year":"2014","journal-title":"American Journal of Psychiatry."},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2013.05.028"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2009.00726.x"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2009.01506.x"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.133.5.429"}],"container-title":["Journal of Child Psychology and Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpp.12332","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpp.12332","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcpp.12332","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acamh.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpp.12332","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T16:58:45Z","timestamp":1762189125000},"score":1,"resource":{"primary":{"URL":"https:\/\/acamh.onlinelibrary.wiley.com\/doi\/10.1111\/jcpp.12332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,26]]},"references-count":46,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1111\/jcpp.12332"],"URL":"https:\/\/doi.org\/10.1111\/jcpp.12332","archive":["Portico"],"relation":{},"ISSN":["0021-9630","1469-7610"],"issn-type":[{"value":"0021-9630","type":"print"},{"value":"1469-7610","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,26]]}}}