{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:55:39Z","timestamp":1790841339520,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,1,26]],"date-time":"2015-01-26T00:00:00Z","timestamp":1422230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006484","name":"Vifor Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Child Psychology Psychiatry"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Previous studies have reported that cognitive deficits occur in patients with anorexia nervosa (\n                      <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>\n                      ) and that these deficits may represent a predisposition towards developing\n                      <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>\n                      or perpetuate the disorder. Specifically, dysfunctional implicit learning may contribute to the development of highly resistant dieting behaviours that are fundamental to the persistence of the disorder. Thus, the aims of this study were (a) to investigate implicit sequence learning in adolescent patients with\n                      <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>\n                      before and after weight recovery and (b) to elucidate the associated neural mechanisms in acute\n                      <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>\n                      relative to healthy controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In a behavioural study, implicit sequence learning was assessed using a serial reaction time task in 27 adolescents with\n                      <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>\n                      before (T1) and after weight recovery (T2) compared with age\u2010matched healthy controls (\n                      <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>\n                      ) who were assessed at similar time intervals. The neural correlates of implicit sequence learning were subsequently investigated in 19\n                      <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>\n                      patients shortly after they were admitted to the hospital and 20\n                      <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>\n                      using functional magnetic resonance imaging (\n                      <jats:styled-content style=\"fixed-case\">fMRI<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At T1,\n                      <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>\n                      patients showed reduced sequence learning compared with\n                      <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>\n                      . However, no behavioural differences between\n                      <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>\n                      patients were found at T2. At the neural level, acute\n                      <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>\n                      patients showed reduced thalamic activation during sequence learning compared with\n                      <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>\n                      subjects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our data suggest that the impaired implicit learning observed in adolescent\n                      <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>\n                      patients before weight gain is a state\u2010related dysfunction that normalises with weight gain. Thus, implicit learning deficits do not appear to represent a predisposition towards developing\n                      <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>\n                      ; rather, these deficits should be considered when planning psychotherapeutic interventions for acute\n                      <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>\n                      . Reduced thalamic activation during the acute stage of\n                      <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>\n                      may indicate a starvation\u2010induced dysfunction of the neural circuitry that is involved in behavioural flexibility.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpp.12384","type":"journal-article","created":{"date-parts":[[2015,1,27]],"date-time":"2015-01-27T00:16:40Z","timestamp":1422317800000},"page":"1168-1176","source":"Crossref","is-referenced-by-count":17,"title":["Implicit sequence learning in juvenile anorexia nervosa: neural mechanisms and the impact of starvation"],"prefix":"10.1111","volume":"56","author":[{"given":"Christine","family":"Firk","sequence":"first","affiliation":[{"name":"Department of Child and Adolescent Psychiatry University Hospital RWTH Aachen Aachen 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