{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T16:05:24Z","timestamp":1781712324102,"version":"3.54.5"},"reference-count":55,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,6,13]],"date-time":"2015-06-13T00:00:00Z","timestamp":1434153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Child Psychology Psychiatry"],"published-print":{"date-parts":[[2016,1]]},"abstract":"\n Background<\/jats:title>\n \n Tourette syndrome (\n TS<\/jats:styled-content>\n ) is a common tic disorder in children and adolescents. There is preliminary evidence that herbal medicine may possess the potential to treat tics. The purpose of this study was to formally evaluate the efficacy and safety of 5\u2010Ling Granule (5\u2010\n LG<\/jats:styled-content>\n r), a proprietary polyherbal product, for the treatment of patients with\n TS<\/jats:styled-content>\n in comparison with tiapride and placebo.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In this multisite, double\u2010blind, double\u2010dummy, randomized, placebo\u2010controlled trial, 603 patients with\n TS<\/jats:styled-content>\n aged 5\u201318\u00a0years were randomly assigned to treatment with placebo (\n n<\/jats:italic>\n \u00a0=\u00a0117), tiapride (\n n<\/jats:italic>\n \u00a0=\u00a0123, 200\u2013400\u00a0mg\/day) or 5\u2010\n LG<\/jats:styled-content>\n r (\n n<\/jats:italic>\n \u00a0=\u00a0363, 15\u201322.5\u00a0g\/day) for 8\u00a0weeks. The primary outcome was measured using the Yale Global Tic Severity Scale (\n YGTSS<\/jats:styled-content>\n ) and its subscales, total tic Score (\n TTS<\/jats:styled-content>\n ) and tic\u2010related impairment. Incidence of adverse events was compared among the three groups.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n While tics of all patients were reduced over time, 5\u2010\n LG<\/jats:styled-content>\n r and tiapride treatment produced significantly greater improvement on the\n YGTSS<\/jats:styled-content>\n overall scale and subscale for\n TTS<\/jats:styled-content>\n and impairment at endpoint than the placebo. Seventy\u2010four percentage of patients in the 5\u2010\n LG<\/jats:styled-content>\n r arm and 68.3% in the tiapride arm had clinical response and these rates of response were significantly higher than those on placebo (44.0%,\n p\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n .001). The incidence of overall adverse events was significantly fewer for patients on placebo and 5\u2010\n LG<\/jats:styled-content>\n r compared to tiapride (11.2% and 13.8% vs. 26.0%,\n p\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n .002); in particular physical tiredness, dizziness and sleep disturbance.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The clinical efficacy of 5\u2010\n LG<\/jats:styled-content>\n r is comparable to tiapride in reducing tics. Its safety profile is better than tiapride. 5\u2010\n LG<\/jats:styled-content>\n r can be considered a safe and effective therapy for\n TS<\/jats:styled-content>\n (Trial registration:\n www.clinicaltrials.gov<\/jats:ext-link>\n :\n NCT<\/jats:styled-content>\n 01501695).\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jcpp.12432","type":"journal-article","created":{"date-parts":[[2015,6,13]],"date-time":"2015-06-13T02:44:40Z","timestamp":1434163480000},"page":"74-83","source":"Crossref","is-referenced-by-count":64,"title":["A proprietary herbal medicine (5\u2010\n L<\/scp>\n ing\n G<\/scp>\n ranule) for\n T<\/scp>\n ourette syndrome: a randomized controlled trial"],"prefix":"10.1111","volume":"57","author":[{"given":"Yi","family":"Zheng","sequence":"first","affiliation":[{"name":"Beijing Institutes for Brain Disorders Beijing Anding Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang\u2010Jin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Institutes for Brain Disorders Beijing Anding Hospital Capital Medical University Beijing China"},{"name":"School of Chinese Medicine LKS Faculty of Medicine The University of Hong Kong Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin\u2010Min","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Yan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The First Affiliated\u00a0Hospital of Zhejiang University of Chinese Medicine Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue\u2010Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Affiliated Hospital of Liaoning University of Chinese Medicine Shenyang Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Wei","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The First Affiliated Hospital of Tianjin University of Chinese Medicine Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min\u2010Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Nanjing Brain Hospital Affiliated to Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Second Affiliated Hospital of Tianjin University of Chinese Medicine Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao\u2010Hong","family":"Nie","sequence":"additional","affiliation":[{"name":"Tasly Pharmaceutical Company Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhao","sequence":"additional","affiliation":[{"name":"Tasly Pharmaceutical Company Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi\u2010Xi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Peking Union Medical College (PUMC) Hospital Chinese Academy of Medical Sciences Beijing 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Song Z.H. Zhang L.L. Zhu Y.H. &Cai N.(inventors). (2011).Traditional Chinese medicinal composition for treating Tourette syndrome and preparation method of traditional Chinese medicinal composition.China Patent Publication Number: CN102579842A. 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