{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T22:27:11Z","timestamp":1788560831928,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,2,12]],"date-time":"2016-02-12T00:00:00Z","timestamp":1455235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01MH62873"],"award-info":[{"award-number":["R01MH62873"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004321","name":"Shire","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Child Psychology Psychiatry"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Task\u2010based and resting\u2010state functional Magnetic Resonance Imaging (fMRI) studies report attention\u2010deficit\/hyperactivity disorder (\n                      <jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content>\n                      )\u2010related alterations in brain regions implicated in cortico\u2010striatal networks. We assessed whether\n                      <jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content>\n                      is associated with changes in the brain's global cortico\u2010striatal functional architecture, or whether\n                      <jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content>\n                      \u2010related alterations are limited to local, intrastriatal functional connections.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We included a cohort of adolescents with\n                      <jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content>\n                      (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a0181) and healthy controls (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a0140) and assessed functional connectivity of nucleus accumbens, caudate nucleus, anterior putamen, and posterior putamen. To assess global cortico\u2010striatal functional architecture we computed whole\u2010brain functional connectivity by including all regions of interest in one multivariate analysis. We assessed local striatal functional connectivity using partial correlations between the time series of the striatal regions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Diagnostic status did not influence global cortico\u2010striatal functional architecture. However, compared to controls, participants with\n                      <jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content>\n                      exhibited significantly increased local functional connectivity between anterior and posterior putamen (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.0003;\n                      <jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content>\n                      :\n                      <jats:italic>z<\/jats:italic>\n                      \u00a0=\u00a0.30, controls:\n                      <jats:italic>z<\/jats:italic>\n                      \u00a0=\u00a0.24). Results were not affected by medication use or comorbid oppositional defiant disorder and conduct disorder.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our results do not support hypotheses that\n                      <jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content>\n                      is associated with alterations in cortico\u2010striatal networks, but suggest changes in local striatal functional connectivity. We interpret our findings as aberrant development of local functional connectivity of the putamen, potentially leading to decreased functional segregation between anterior and posterior putamen in\n                      <jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpp.12529","type":"journal-article","created":{"date-parts":[[2016,2,12]],"date-time":"2016-02-12T10:33:47Z","timestamp":1455273227000},"page":"697-705","source":"Crossref","is-referenced-by-count":27,"title":["Aberrant local striatal functional connectivity in attention\u2010deficit\/hyperactivity disorder"],"prefix":"10.1111","volume":"57","author":[{"given":"Daniel","family":"von Rhein","sequence":"first","affiliation":[{"name":"Department of Cognitive Neuroscience Radboud University Medical Center Nijmegen The Netherlands"},{"name":"Donders Institute for Brain, Cognition and Behavior Radboud 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Neuropsychology VU University Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Heslenfeld","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuropsychology VU University Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina A.","family":"Hartman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University Medical Center Groningen University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter J.","family":"Hoekstra","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University Medical Center Groningen University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Franke","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Radboud University 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