{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T11:36:02Z","timestamp":1762169762758,"version":"build-2065373602"},"reference-count":8,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T00:00:00Z","timestamp":1471478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008771","name":"Tourette Association of America","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008771","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Child Psychology Psychiatry"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p>\n                    In this issue, Whittington et\u00a0al. (2016) present a systematic review that reports the efficacy of three primary treatments for children with Tourette syndrome (TS) \u2013 (a)\n                    <jats:italic>\u03b1<\/jats:italic>\n                    2\u2010adrenergic receptor agonists; (b) antipsychotic medications; and (c) habit reversal training\/comprehensive behavioral intervention. In this commentary, we highlight the large degree of heterogeneity observed in the meta\u2010analysis of trials involving alpha\u20102 agonist medications and present possible explanations for the observed heterogeneity. Among these possible explanations is the possibility that presence of comorbid\n                    <jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content>\n                    may moderate the efficacy of alpha\u20102 agonists in the treatment of tic disorder with the medications being more effective in patients with both conditions. The commentary reviews the evidence supporting this possible moderating effect of\n                    <jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content>\n                    and discusses the implications for such a relationship.\n                  <\/jats:p>","DOI":"10.1111\/jcpp.12592","type":"journal-article","created":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T07:30:47Z","timestamp":1471505447000},"page":"1005-1007","source":"Crossref","is-referenced-by-count":10,"title":["Commentary: Are alpha\u20102 agonist really effective in children with tics with comorbid ADHD? A commentary on Whittington et\u00a0al. (2016)"],"prefix":"10.1111","volume":"57","author":[{"given":"Michael H.","family":"Bloch","sequence":"first","affiliation":[{"name":"Yale Child Study Center and the Department of Psychiatry Yale University New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,18]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_3_2_1","DOI":"10.1080\/00048670802277222"},{"doi-asserted-by":"publisher","key":"e_1_2_3_3_1","DOI":"10.1176\/appi.ajp.2009.08091354"},{"doi-asserted-by":"publisher","key":"e_1_2_3_4_1","DOI":"10.1016\/j.jaac.2013.09.015"},{"doi-asserted-by":"publisher","key":"e_1_2_3_5_1","DOI":"10.1177\/070674371205700302"},{"doi-asserted-by":"publisher","key":"e_1_2_3_6_1","DOI":"10.1007\/s00787-011-0163-7"},{"doi-asserted-by":"publisher","key":"e_1_2_3_7_1","DOI":"10.1212\/WNL.58.4.527"},{"doi-asserted-by":"publisher","key":"e_1_2_3_8_1","DOI":"10.1016\/j.neubiorev.2012.09.008"},{"doi-asserted-by":"publisher","key":"e_1_2_3_9_1","DOI":"10.1111\/jcpp.12556"}],"container-title":["Journal of Child Psychology and Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpp.12592","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpp.12592","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acamh.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpp.12592","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T11:16:42Z","timestamp":1762168602000},"score":1,"resource":{"primary":{"URL":"https:\/\/acamh.onlinelibrary.wiley.com\/doi\/10.1111\/jcpp.12592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,18]]},"references-count":8,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1111\/jcpp.12592"],"URL":"https:\/\/doi.org\/10.1111\/jcpp.12592","archive":["Portico"],"relation":{},"ISSN":["0021-9630","1469-7610"],"issn-type":[{"type":"print","value":"0021-9630"},{"type":"electronic","value":"1469-7610"}],"subject":[],"published":{"date-parts":[[2016,8,18]]}}}