{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:38:10Z","timestamp":1788349090482,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,9,8]],"date-time":"2016-09-08T00:00:00Z","timestamp":1473292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB TRR\u201058 C01"],"award-info":[{"award-number":["SFB TRR\u201058 C01"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Child Psychology Psychiatry"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      An altered pattern of threat processing is deemed critical for the development of anxiety disorders (\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      ). According to the hypervigilance\u2010avoidance hypothesis,\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      patients show hypervigilance to threat cues at early stages of processing but avoid threat cues at later stages of processing. Consistently, adults with\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      show enhanced neurophysiological responses to threat in early time windows and reduced responses to threat in late time windows. The presence of such a hypervigilance\u2010avoidance effect and its underlying neural sources remain to be determined in clinically anxious children.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010three children diagnosed with an\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      and 23 healthy control children aged 8\u201314\u00a0years saw faces with angry and neutral expressions while whole\u2010head magnetoencephalography (MEG) was recorded. Neural sources were estimated based on L2\u2010Minimum Norm inverse source modeling and analyzed in early, midlatency, and late time windows.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In visual cortical regions, early threat processing was relatively enhanced in patients compared to controls, whereas this relation was inverted in a late interval. Consistent with the idea of affective regulation, the right dorsolateral prefrontal cortex revealed relatively reduced inhibition of early threat processing but revealed enhanced inhibition at a late interval in patients. Both visual\u2010sensory and prefrontal effects were correlated with individual trait anxiety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results support the hypothesis of early sensory hypervigilance followed by later avoidance of threat in anxiety disordered children, presumably modulated by early reduced and later enhanced prefrontal inhibition. This neuronal hypervigilance\u2010avoidance pattern unfolds\u00a0gradually with increasing trait anxiety, reflecting a progressively biased allocation of attention to threat.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpp.12617","type":"journal-article","created":{"date-parts":[[2016,9,8]],"date-time":"2016-09-08T02:09:10Z","timestamp":1473300550000},"page":"103-112","source":"Crossref","is-referenced-by-count":14,"title":["Hypervigilance\u2010avoidance in children with anxiety disorders: magnetoencephalographic evidence"],"prefix":"10.1111","volume":"58","author":[{"given":"Ida","family":"Wessing","sequence":"first","affiliation":[{"name":"Department for Child and Adolescent Psychiatry University Hospital M\u00fcnster M\u00fcnster Germany"},{"name":"Institute for Biomagnetism and Biosignalanalysis University Hospital M\u00fcnster M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Romer","sequence":"additional","affiliation":[{"name":"Department for Child and Adolescent Psychiatry University Hospital M\u00fcnster M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Jungh\u00f6fer","sequence":"additional","affiliation":[{"name":"Institute for Biomagnetism and Biosignalanalysis University Hospital M\u00fcnster M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.05.015"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2011.11.010"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1515\/rns.2011.056"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.133.1.1"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psc.2009.06.002"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chc.2012.05.002"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-7916(94)90063-9"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.10.031"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071289"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2009.11.003"},{"key":"e_1_2_8_12_1","volume-title":"Diagnostik\u2010System f\u00fcr psychische St\u00f6rungen nach ICD\u201010 und DSM\u2010IV f\u00fcr Kinder und Jugendliche\u2010II (DISYPS\u2010II); 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