{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:59:29Z","timestamp":1791817169838,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T00:00:00Z","timestamp":1483660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DA036216"],"award-info":[{"award-number":["DA036216"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DA05147"],"award-info":[{"award-number":["DA05147"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AA09367"],"award-info":[{"award-number":["AA09367"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Child Psychology Psychiatry"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      This study was undertaken to determine how well two oppositional defiant disorder (\n                      <jats:styled-content style=\"fixed-case\">ODD<\/jats:styled-content>\n                      ) dimensions (irritable and headstrong\/hurtful) assessed in childhood predict late adolescent psychopathology and the degree to\u00a0which these outcomes can be attributed to genetic influences shared with\n                      <jats:styled-content style=\"fixed-case\">ODD<\/jats:styled-content>\n                      dimensions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Psychopathology was assessed via diagnostic interviews of 1,225 twin pairs at ages 11 and 17.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Consistent with hypotheses, the irritable dimension uniquely predicted overall internalizing problems, whereas the headstrong\/hurtful dimension uniquely predicted substance use disorder symptoms. Both dimensions were predictive of antisocial behavior and overall externalizing problems. The expected relationships between the irritable dimension and specific internalizing disorders were not found. Twin modeling showed that the irritable and headstrong\/hurtful dimensions were related to late adolescent psychopathology symptoms through common genetic influences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Symptoms of\n                      <jats:styled-content style=\"fixed-case\">ODD<\/jats:styled-content>\n                      in childhood pose a significant risk for various mental health outcomes in late adolescence. Further, common genetic influences underlie the covariance between irritable symptoms in childhood and overall internalizing problems in late adolescence, whereas headstrong\/hurtful symptoms share genetic influences with substance use disorder symptoms. Antisocial behavior and overall externalizing share common genetic influences with both the irritable and headstrong\/hurtful dimensions.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpp.12683","type":"journal-article","created":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T07:06:59Z","timestamp":1483686419000},"page":"702-710","source":"Crossref","is-referenced-by-count":36,"title":["Oppositional defiant disorder dimensions: genetic influences and risk for later psychopathology"],"prefix":"10.1111","volume":"58","author":[{"given":"Amy J.","family":"Mikolajewski","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences School of Medicine Tulane University New Orleans LA USA"},{"name":"Department of Psychology Florida State University Tallahassee FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanette","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of 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