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We hypothesize that inhibitory control mechanisms during early stimulus categorization and integration into a knowledge system underlie these deficits.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We examined\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a025 adolescent\n                      <jats:styled-content style=\"fixed-case\">OCD<\/jats:styled-content>\n                      patients and matched healthy controls (\n                      <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>\n                      ) in a paradigm manipulating the importance of the knowledge system to perform task switching. This was done using a paradigm in which task switches were signaled either by visual stimuli or by working memory processes. This was combined with event\u2010related potential recordings and source localization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Obsessive compulsive disorder patients showed increased switch costs in the memory as compared with the cue\u2010based block, while\n                      <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>\n                      showed similar switch costs in both blocks. At the neurophysiological level, these changes in\n                      <jats:styled-content style=\"fixed-case\">OCD<\/jats:styled-content>\n                      were not reflected by the N2 and P3 reflecting response\u2010associated processes but by the P1 reflecting inhibitory control during sensory categorization processes. Activation differences in the right inferior frontal gyrus and superior temporal gyrus are associated with the P1 effect.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Cognitive flexibility in adolescent\n                      <jats:styled-content style=\"fixed-case\">OCD<\/jats:styled-content>\n                      patients is strongly modulated by working memory load. Contrary to common sense, not response\u2010associated processes, but inhibitory control mechanisms during early stimulus categorization processes are likely to underlie cognitive inflexibility in OCD. These processes are associated with right inferior frontal and superior temporal gyrus mechanisms.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpp.12733","type":"journal-article","created":{"date-parts":[[2017,4,28]],"date-time":"2017-04-28T07:53:47Z","timestamp":1493366027000},"page":"939-949","source":"Crossref","is-referenced-by-count":21,"title":["Modulations of cognitive flexibility in obsessive compulsive disorder reflect dysfunctions of perceptual categorization"],"prefix":"10.1111","volume":"58","author":[{"given":"Nicole","family":"Wolff","sequence":"first","affiliation":[{"name":"Cognitive Neurophysiology Department of Child and Adolescent Psychiatry Faculty of Medicine of the TU Dresden Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Buse","sequence":"additional","affiliation":[{"name":"Cognitive Neurophysiology Department of Child and Adolescent Psychiatry Faculty of Medicine of the TU 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