{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:27:58Z","timestamp":1790972878195,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T00:00:00Z","timestamp":1523923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01 MH093479"],"award-info":[{"award-number":["R01 MH093479"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Child Psychology Psychiatry"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      An increased neural response to making mistakes has emerged as a potential biomarker of anxiety across development. The error\u2010related negativity (ERN) is an event\u2010related potential elicited when people make mistakes on simple laboratory\u2010based reaction time tasks that has been associated with risk for anxiety. This study examined whether the ERN prospectively predicted the first onset of generalized anxiety disorder (\n                      <jats:styled-content style=\"fixed-case\">GAD<\/jats:styled-content>\n                      ) over 1.5\u00a0years in adolescent girls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The sample included 457 girls between the ages of 13.5 and 15.5\u00a0years, with no history of\n                      <jats:styled-content style=\"fixed-case\">GAD<\/jats:styled-content>\n                      . At baseline, the ERN was measured using a flankers task. Psychiatric history of the adolescent and biological parent was assessed with diagnostic interviews, and the adolescent completed a self\u2010report questionnaire regarding anxiety symptoms. Approximately 1.5\u00a0years later, adolescents completed the same interview.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      An increased neural response to errors at baseline predicted first\u2010onset\n                      <jats:styled-content style=\"fixed-case\">GAD<\/jats:styled-content>\n                      over 1.5\u00a0years. The ERN was a significant predictor independent of other prominent risk factors, including baseline anxiety and depression symptoms and parental lifetime psychiatric history. Jointly the ERN and social anxiety symptoms provided the greatest power for predicting first\u2010onset\n                      <jats:styled-content style=\"fixed-case\">GAD<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study provides evidence for the utility of the ERN as a biomarker of risk for\n                      <jats:styled-content style=\"fixed-case\">GAD<\/jats:styled-content>\n                      during a key developmental period.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpp.12922","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T14:23:32Z","timestamp":1523975012000},"page":"1162-1170","source":"Crossref","is-referenced-by-count":81,"title":["A neural biomarker, the error\u2010related 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