{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:33:34Z","timestamp":1793392414591,"version":"4.5.0"},"reference-count":55,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:00:00Z","timestamp":1567555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012505","name":"Royal Perth Hospital Medical Research Foundation","doi-asserted-by":"publisher","award":["MR\/R004889\/1"],"award-info":[{"award-number":["MR\/R004889\/1"]}],"id":[{"id":"10.13039\/100012505","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000883","name":"University of Bristol","doi-asserted-by":"publisher","award":["MC_UU_00011\/1"],"award-info":[{"award-number":["MC_UU_00011\/1"]}],"id":[{"id":"10.13039\/501100000883","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000883","name":"University of Bristol","doi-asserted-by":"publisher","award":["MC_UU_00011\/4"],"award-info":[{"award-number":["MC_UU_00011\/4"]}],"id":[{"id":"10.13039\/501100000883","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000883","name":"University of Bristol","doi-asserted-by":"publisher","award":["MC_UU_00011\/5"],"award-info":[{"award-number":["MC_UU_00011\/5"]}],"id":[{"id":"10.13039\/501100000883","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["102215\/2\/13\/2"],"award-info":[{"award-number":["102215\/2\/13\/2"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["GR067797MA"],"award-info":[{"award-number":["GR067797MA"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012141","name":"University Hospitals Bristol NHS Foundation Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acamh.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Child Psychology Psychiatry"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Adverse childhood experiences (ACEs) such as physical and emotional abuse are strongly associated with self\u2010harm, but mechanisms underlying this relationship are unclear. Inflammation has been linked to both the experience of ACEs and self\u2010harm or suicide in prior research. This is the first study to examine whether inflammatory markers mediate the association between exposure to ACEs and self\u2010harm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants were 4,308 young people from the Avon Longitudinal Study of Parents and Children (ALSPAC), a population\u2010based birth cohort in the United Kingdom. A structural equation modelling approach was used to fit a mediation model with the number of ACEs experienced between ages 0 and 9\u00a0years old (yo), levels of the inflammatory markers interleukin\u20106 and C\u2010reactive protein measured at 9.5\u00a0yo, and self\u2010harm reported at 16\u00a0yo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean number of ACEs young people experienced was 1.41 (\n                      <jats:italic>SE<\/jats:italic>\n                      0.03). Higher ACE scores were associated with an increased risk of self\u2010harm at 16\u00a0yo (direct effect relative risk (RR) per additional ACE 1.11, 95% CI 1.05, 1.18,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). We did not find evidence of an indirect effect of ACEs on self\u2010harm via inflammation (RR 1.00, 95% CI 1.00, 1.01,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.38).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Young people who have been exposed to ACEs are a group at high risk of self\u2010harm. The association between ACEs and self\u2010harm does not appear to be mediated by an inflammatory process in childhood, as indexed by peripheral levels of circulating inflammatory markers measured in childhood. Further research is needed to identify alternative psychological and biological mechanisms underlying this relationship.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpp.13100","type":"journal-article","created":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T01:01:17Z","timestamp":1567645277000},"page":"1094-1103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Pathways between early\u2010life adversity and adolescent self\u2010harm: the mediating role of inflammation in the Avon Longitudinal Study of Parents and Children"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2903-6264","authenticated-orcid":false,"given":"Abigail Emma","family":"Russell","sequence":"first","affiliation":[{"name":"Centre for Academic Mental Health Population Health Sciences University of Bristol Medical School Bristol 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