{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:43:18Z","timestamp":1791420198076,"version":"4.3.3"},"reference-count":55,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T00:00:00Z","timestamp":1568246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["K01MH107763"],"award-info":[{"award-number":["K01MH107763"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01 MH093479"],"award-info":[{"award-number":["R01 MH093479"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acamh.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Child Psychology Psychiatry"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Adolescence is characterized by affective and cognitive changes that increase vulnerability to depression, especially in females. Neurodevelopmental models attribute adolescent depression to abnormal responses in amygdala, striatum, and prefrontal cortex (PFC). We examined whether the strength of functional brain networks involving these regions predicts depression symptoms in adolescent females.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this longitudinal study, we recorded resting\u2010state functional connectivity (RSFC) in 174 adolescent females. Using a cross\u2010validation strategy, we related RSFC profiles that included (a) a network consisting of amygdala, striatum, and PFC (\n                      <jats:italic>within\u2010circuit<\/jats:italic>\n                      model), (b) connectivity of this network to the whole brain (\n                      <jats:italic>extended\u2010circuit<\/jats:italic>\n                      model), and (c) a network consisting of the entire brain (\n                      <jats:italic>whole\u2010brain<\/jats:italic>\n                      model) to depression symptoms assessed concurrently and 18\u00a0months later.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In testing subsets, the\n                      <jats:italic>within\u2010circuit<\/jats:italic>\n                      RSFC profiles were associated with depression symptoms concurrently and 18\u00a0months later, while the\n                      <jats:italic>extended\u2010circuit<\/jats:italic>\n                      and\n                      <jats:italic>whole\u2010brain<\/jats:italic>\n                      model did not explain any additional variance in depression symptoms. Connectivity related to anterior cingulate and ventromedial prefrontal cortex contributed most to the association.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results demonstrate that RSFC\u2010based brain networks that include amygdala, striatum, and PFC are stable neural signatures of concurrent and future depression symptoms, representing a significant step toward identifying the neural mechanism of depression in adolescence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpp.13123","type":"journal-article","created":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T05:59:57Z","timestamp":1568267997000},"page":"480-491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Intrinsic neural circuitry of depression in adolescent 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