{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T20:10:20Z","timestamp":1783541420798,"version":"3.55.0"},"reference-count":53,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,11,17]],"date-time":"2019-11-17T00:00:00Z","timestamp":1573948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006350","name":"Stiftelsen Clas Groschinskys Minnesfond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006350","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007605","name":"Aarhus Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007605","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007437","name":"TrygFonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007437","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acamh.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Child Psychology Psychiatry"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>First\u2010line treatments for pediatric obsessive\u2013compulsive disorder (OCD) include exposure\u2010based cognitive\u2010behavioral therapy (CBT) and selective serotonin reuptake inhibitors (SSRIs). No studies have thus far identified distinct classes and associated predictors of long\u2010term symptom severity during and after treatment. Yet, these could form the basis for more personalized treatment in pediatric OCD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      The study included 269 OCD patients aged 7\u221217\u00a0years from the Nordic Long\u2010term OCD Treatment Study (NordLOTS). All participants received stepped\u2010care treatment starting with 14 weekly sessions of manualized CBT. Nonresponders were randomized to either prolonged CBT or SSRIs. Symptom severity was assessed using the Children's Yale\u2010Brown Obsessive\u2010Compulsive Scale at seven time points from pre\u2010 to post\u2010treatment and over a three\u2010year follow\u2010up. Latent class growth analysis (LCGA) was performed to identify latent classes of symptom severity trajectories. Univariate and multivariate analyses were used to detect differences between classes and identify predictors of trajectory class membership including several clinical and demographic variables. Trial registry: Nordic Long\u2010term Obsessive\u2010Compulsive Disorder (OCD) Treatment Study;\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.controlled-trials.com\">www.controlled-trials.com<\/jats:ext-link>\n                      ; ISRCTN66385119.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Three LCGA classes were identified: (a)\n                      <jats:italic>acute, sustained responders<\/jats:italic>\n                      (54.6%); (b)\n                      <jats:italic>slow, continued responders<\/jats:italic>\n                      (23.4%); and (c)\n                      <jats:italic>limited long\u2010term responders<\/jats:italic>\n                      (21.9%). Class membership was predicted by distinct baseline characteristics pertaining to age, symptom severity, contamination\/cleaning and anxiety symptoms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The LCGA suggests three distinct trajectory classes of long\u2010term symptom severity during and after treatment in pediatric OCD with different clinical profiles at pretreatment. The results point to required clinical attention for adolescent patients with contamination\/cleaning and anxiety symptoms who do not show convincing responses to first\u2010line treatment even though they may have reached the established cutoff for treatment response.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpp.13155","type":"journal-article","created":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T00:01:20Z","timestamp":1574035280000},"page":"969-978","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Distinct trajectories of long\u2010term symptom severity in pediatric obsessive\u2013compulsive disorder during and after stepped\u2010care treatment"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8095-2700","authenticated-orcid":false,"given":"Sanne","family":"Jensen","sequence":"first","affiliation":[{"name":"Department of Child and Adolescent 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