{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T05:56:35Z","timestamp":1775195795170,"version":"3.50.1"},"reference-count":55,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T00:00:00Z","timestamp":1577750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["1R21MH101441"],"award-info":[{"award-number":["1R21MH101441"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acamh.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Child Psychology Psychiatry"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cognitive behavioral therapy (CBT) is an effective, first\u2010line treatment for pediatric obsessive\u2010compulsive disorder (OCD). While neural predictors of treatment outcomes have been identified in adults with OCD, robust predictors are lacking for pediatric patients. Herein, we sought to identify brain structural markers of CBT response in youth with OCD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010eight\u00a0children\/adolescents with OCD and 27 matched healthy participants (7\u2010 to 18\u2010year\u2010olds,\n                      <jats:italic>M<\/jats:italic>\n                      \u00a0=\u00a011.71\u00a0years,\n                      <jats:italic>SD<\/jats:italic>\n                      \u00a0=\u00a03.29) completed high\u2010resolution structural and diffusion MRI (all unmedicated at time of scanning). Patients with OCD then completed 12\u201316 sessions of CBT. Subcortical volume and cortical thickness were estimated using FreeSurfer. Structural connectivity (streamline counts) was estimated using MRtrix.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thinner cortex in nine frontoparietal regions significantly predicted improvement in Children\u2019s Yale\u2010Brown Obsessive\u2010Compulsive Scale (CY\u2010BOCS) scores (all\n                      <jats:italic>t<\/jats:italic>\n                      s\u00a0&gt;\u00a03.4, FDR\u2010corrected\n                      <jats:italic>p<\/jats:italic>\n                      s\u00a0&lt;\u00a0.05). These included middle and superior frontal, angular, lingual, precentral, superior temporal, and supramarginal gyri (SMG). Vertex\u2010wise analyses confirmed a significant left SMG cluster, showing large effect size (Cohen\u2019s\n                      <jats:italic>d<\/jats:italic>\n                      \u00a0=\u00a01.42) with 72.22% specificity and 90.00% sensitivity in predicting CBT response. Ten structural connections between cingulo\u2010opercular regions exhibited fewer streamline counts in OCD (all\n                      <jats:italic>t<\/jats:italic>\n                      s\u00a0&gt;\u00a03.12, Cohen\u2019s\n                      <jats:italic>d<\/jats:italic>\n                      s\u00a0&gt;\u00a00.92) compared with healthy participants. These connections predicted post\u2010treatment CY\u2010BOCS scores, beyond pretreatment severity and demographics, though not above and beyond cortical thickness.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The current study identified group differences in structural connectivity (reduced among cingulo\u2010opercular regions) and cortical thickness predictors of CBT response (thinner frontoparietal cortices) in unmedicated children\/adolescents with OCD. These data suggest, for the first time, that cortical and white matter features of task control circuits may be useful in identifying which pediatric patients respond best to individual CBT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpp.13191","type":"journal-article","created":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T04:27:10Z","timestamp":1577766430000},"page":"1299-1308","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Structural neural markers of response to cognitive behavioral therapy in pediatric obsessive\u2010compulsive disorder"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1214-1965","authenticated-orcid":false,"given":"David","family":"Pagliaccio","sequence":"first","affiliation":[{"name":"Division of Child and Adolescent Psychiatry New York State Psychiatric Institute New York NY USA"},{"name":"Department of Psychiatry Vagelos College of Physicians and Surgeons Columbia University New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiook","family":"Cha","sequence":"additional","affiliation":[{"name":"Division of Child and Adolescent Psychiatry New York State Psychiatric Institute New York NY USA"},{"name":"Department of Psychiatry Vagelos College of Physicians and Surgeons Columbia University New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofu","family":"He","sequence":"additional","affiliation":[{"name":"Division of Child and Adolescent Psychiatry New York State Psychiatric Institute New York NY USA"},{"name":"Department of Psychiatry Vagelos College of Physicians and Surgeons Columbia University New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1605-0427","authenticated-orcid":false,"given":"Marilyn","family":"Cyr","sequence":"additional","affiliation":[{"name":"Division of Child and Adolescent Psychiatry New York State Psychiatric Institute New York NY USA"},{"name":"Department of Psychiatry Vagelos College of Physicians and Surgeons Columbia University New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Yanes\u2010Lukin","sequence":"additional","affiliation":[{"name":"Division of Child and Adolescent Psychiatry New York State Psychiatric Institute New York NY USA"},{"name":"Department of Psychiatry Vagelos College of Physicians and Surgeons Columbia University New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Division of Child and Adolescent Psychiatry New York State Psychiatric Institute New York NY USA"},{"name":"Department of Psychiatry Vagelos College of Physicians and Surgeons Columbia University New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martine","family":"Fontaine","sequence":"additional","affiliation":[{"name":"Division of Child and Adolescent Psychiatry New York State Psychiatric Institute New York NY USA"},{"name":"Department of Psychiatry Vagelos College of Physicians and Surgeons Columbia University New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moira A.","family":"Rynn","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Behavioral Sciences Duke University School of Medicine Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Marsh","sequence":"additional","affiliation":[{"name":"Division of Child and Adolescent Psychiatry New York State Psychiatric Institute New York NY USA"},{"name":"Department of Psychiatry Vagelos College of Physicians and Surgeons Columbia University New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,31]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"The anxiety disorders interview schedule for children for DSM\u2010IV: Clinician manual (child and parent versions)","author":"Albano A.","year":"1996"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","unstructured":"Bates D. M\u00e4chler M. Bolker B. &Walker S.(2014).Fitting linear mixed\u2010effects models using lme4. arXiv preprint arXiv:1406.5823.","DOI":"10.18637\/jss.v067.i01"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2018.07.897"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2017.17050485"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2016.16020201"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2013.02.003"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/15622975.2015.1102323"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.021"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.010"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.36"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00569-X"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2014.08.010"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2013.09.002"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291713001128"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2010.06.013"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.138"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.22380"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2012.06.014"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/15622975.2012.674215"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/15622975.2013.819122"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-201012000-00009"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.21890"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.06.081"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beth.2017.01.004"},{"key":"e_1_2_6_26_1","first-page":"5","article-title":"Practice guideline for the treatment of patients with obsessive\u2010compulsive disorder","volume":"164","author":"Koran L.M.","year":"2007","journal-title":"American Journal of Psychiatry"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2008.12.007"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.22330"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2014.06.009"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2017.5227"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579408000606"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.16.1969"},{"key":"e_1_2_6_33_1","volume-title":"OCD in children and adolescents: A cognitive\u2010behavioral treatment manual","author":"March J.S.","year":"1998"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2007.09.005"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e3283112720"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2017.77"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2016.08.003"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1909199116"},{"key":"e_1_2_6_39_1","first-page":"75s","article-title":"Brain white matter integrity and association with age at onset in pediatric obsessive\u2010compulsive disorder","volume":"73","author":"Rosso I.M.","year":"2013","journal-title":"Biological Psychiatry"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.175"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199706000-00023"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2013.04.003"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v67n0214"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.10.004"},{"key":"e_1_2_6_45_1","volume-title":"R: A language and environment for statistical computing","author":"Team R.C.","year":"2015"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.07.037"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.04.021"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22828"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.02.018"},{"key":"e_1_2_6_50_1","first-page":"419","article-title":"Response inhibition and interference control in obsessive\u2010compulsive spectrum disorders","volume":"8","author":"Velzen L.S.","year":"2014","journal-title":"Frontiers in Human Neuroscience"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-019-01320-w"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2007.01875.x"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.107.036558"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2008.23.1.24"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.041"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.06.032"}],"container-title":["Journal of Child Psychology and Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpp.13191","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpp.13191","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcpp.13191","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acamh.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpp.13191","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T17:51:15Z","timestamp":1762192275000},"score":1,"resource":{"primary":{"URL":"https:\/\/acamh.onlinelibrary.wiley.com\/doi\/10.1111\/jcpp.13191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,31]]},"references-count":55,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1111\/jcpp.13191"],"URL":"https:\/\/doi.org\/10.1111\/jcpp.13191","archive":["Portico"],"relation":{},"ISSN":["0021-9630","1469-7610"],"issn-type":[{"value":"0021-9630","type":"print"},{"value":"1469-7610","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,31]]},"assertion":[{"value":"2019-12-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}