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However, the meaning of these genetic discoveries is unclear. Drawing on evidence linking early pregnancy with disinhibitory behavior, we tested the hypothesis that genetic discoveries for age\u2010at\u2010first\u2010birth predict disinhibition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We included participants with genotype data from the two\u2010decade\u2010long Environmental Risk (E\u2010Risk) Study (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a01,999) and the four\u2010decade\u2010long Dunedin Study (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a0918). We calculated a genome\u2010wide polygenic score for age\u2010at\u2010first\u2010birth and tested whether it was associated with a range of disinhibitory outcomes across the life course, including low childhood self\u2010control; risk for externalizing psychopathology; officially recorded criminal offending; substance dependence; informant reports of disinhibitory problems; and number of lifetime sexual partners. We further tested whether associations were attributable to accelerated pubertal maturation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In both cohorts, the age\u2010at\u2010first\u2010birth polygenic score predicted low childhood self\u2010control, externalizing psychopathology, officially recorded criminal offending, substance dependence, and number of sexual partners. Associations were modest, but robust across replication. Childhood disinhibition partly mediated associations between the polygenic score and reproductive behaviors. In contrast, associations were not attributable to accelerated pubertal timing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Genomic discoveries for age\u2010at\u2010first\u2010birth are about more than reproductive biology: They provide insight into the disinhibitory traits and behaviors that accompany early parenthood. Age\u2010at\u2010first\u2010birth is a useful proxy phenotype for researchers interested in disinhibition. Further, interventions that improve self\u2010regulation abilities may benefit young parents and their children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpp.13224","type":"journal-article","created":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T12:58:19Z","timestamp":1585313899000},"page":"1349-1359","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A polygenic score for age\u2010at\u2010first\u2010birth predicts disinhibition"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6695-1026","authenticated-orcid":false,"given":"Leah S.","family":"Richmond\u2010Rakerd","sequence":"first","affiliation":[{"name":"Department of Psychology and Neuroscience Duke University Durham NC USA"},{"name":"Frank Porter Graham Child Development Institute University of North Carolina at Chapel Hill Chapel Hill NC 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