{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:40:12Z","timestamp":1792143612142,"version":"4.4.0"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T00:00:00Z","timestamp":1605830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["F32MH114317"],"award-info":[{"award-number":["F32MH114317"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH091363"],"award-info":[{"award-number":["R01MH091363"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003986","name":"Jacobs Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003986","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000870","name":"John D. and Catherine T. MacArthur Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000870","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acamh.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Child Psychology Psychiatry"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Adolescence has been proposed to be a period of heightened sensitivity to environmental influence. If true, adolescence may present a window of opportunity for recovery for children exposed to early\u2010life adversity. Recent evidence supports adolescent recalibration of stress response systems following early\u2010life adversity. However, it is unknown whether similar recovery occurs in other domains of functioning in adolescence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We use data from the Bucharest Early Intervention Project \u2013 a randomized controlled trial of foster care for children raised in psychosocially depriving institutions \u2013 to examine the associations of the caregiving environment with reward processing, executive functioning, and internalizing and externalizing psychopathology at ages 8, 12, and 16\u00a0years, and evaluate whether these associations change across development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Higher quality caregiving in adolescence was associated with greater reward responsivity and lower levels of internalizing and externalizing symptoms, after covarying for the early\u2010life caregiving environment. The associations of caregiving with executive function and internalizing and externalizing symptoms varied by age and were strongest at age 16 relative to ages 8 and 12\u00a0years. This heightened sensitivity to caregiving in adolescence was observed in both children with and without exposure to early psychosocial neglect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Adolescence may be a period of heightened sensitivity to the caregiving environment, at least for some domains of functioning. For children who experience early psychosocial deprivation, this developmental period may be a window of opportunity for recovery of some functions. Albeit correlational, these findings suggest that it may be possible to reverse or remediate some of the lasting effects of early\u2010life adversity with interventions that target caregiving during adolescence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpp.13347","type":"journal-article","created":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T16:38:39Z","timestamp":1605890319000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Heightened sensitivity to the caregiving environment during adolescence: implications for recovery following early\u2010life adversity"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7878-4250","authenticated-orcid":false,"given":"Natalie L.","family":"Colich","sequence":"first","affiliation":[{"name":"Department of Psychology University of Washington Seattle WA 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