{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T13:46:18Z","timestamp":1793281578265,"version":"4.5.0"},"reference-count":51,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010078","name":"Region Midtjylland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010078","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005275","name":"Region Hovedstaden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005275","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007437","name":"TrygFonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007437","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012774","name":"Innovationsfonden","doi-asserted-by":"publisher","award":["6152\u201000002B"],"award-info":[{"award-number":["6152\u201000002B"]}],"id":[{"id":"10.13039\/100012774","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007605","name":"Aarhus Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007605","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acamh.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Child Psychology Psychiatry"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Children at familial high\u2010risk of schizophrenia and bipolar disorder have an elevated prevalence of mental disorders but studies of children within a narrow age range are lacking and there are few conjoint studies of these two groups. Knowledge on their mental health is important for prevention and early intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The authors examined mental disorders and global functioning in children at familial high\u2010risk of schizophrenia (FHR\u2010SZ) and bipolar disorder (FHR\u2010BP) compared with population\u2010based controls. In a longitudinal cohort study, 450 children (FHR\u2010SZ,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009171; FHR\u2010BP,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009104; controls,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009175), were assessed for Axis I disorders at baseline and four\u2010year follow\u2010up (mean age 11.9,\n                      <jats:italic>SD<\/jats:italic>\n                      0.2) with the Kiddie Schedule for Affective Disorders and Schizophrenia for School\u2010Age Children and for global functioning with Children\u2019s Global Assessment Scale.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Cumulative incidence of Any Axis I disorder was elevated by age 11 in children at FHR\u2010SZ (54.4%, OR 3.0, 95% CI 1.9\u20134.7,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001) and children at FHR\u2010BP (52.9%, OR 2.8, 95% CI 1.7\u20134.7,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001) compared with controls (28.6%). Children at FHR\u2010SZ and FHR\u2010BP had higher rates of affective disorders (OR 4.4, 95% CI 1.4\u201313.5,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.009; OR 5.1, 95% CI 1.6\u201316.4,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.007), anxiety disorders (OR 2.1, 95% CI 1.1\u20134.0,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.02; OR 3.0, 95% CI 1.5\u20136.1,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.002), and stress and adjustment disorders (OR 3.3, 95% CI 1.4\u20137.5,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.006; OR 5.3, 95% CI 2.2\u201312.4,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001). Disruptive behavior disorders (OR 2.8, 95% CI 1.0\u20137.3,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.04) and ADHD (OR 2.9, 95% CI 1.6\u20135.3,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001) were elevated in children at FHR\u2010SZ. Both FHR groups had lower global functioning than controls. Cumulative incidence of disorders increased equally across the three groups from early childhood to preadolescence and level of functioning did not change differentially.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Children at FHR\u2010SZ and FHR\u2010BP  have an elevated prevalence of mental disorders and poorer functioning than controls. Vulnerability in children at FHR manifests early and remains stable throughout childhood. Early attention toward their mental health and identification of those in need of intervention is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpp.13548","type":"journal-article","created":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T01:19:34Z","timestamp":1639703974000},"page":"1046-1056","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Mental disorders in preadolescent children at familial high\u2010risk of schizophrenia or bipolar disorder \u2013 a four\u2010year follow\u2010up study"],"prefix":"10.1111","volume":"63","author":[{"given":"Maja","family":"Gregersen","sequence":"first","affiliation":[{"name":"CORE\u2014Copenhagen Research Center for Mental Health Mental Health Center Copenhagen Mental Health Services in the Capital Region of Denmark  Copenhagen Denmark"},{"name":"The Lundbeck Foundation Initiative for Integrative Psychiatric Research\u2014iPSYCH  Aarhus 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