{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:23:36Z","timestamp":1791404616906,"version":"4.3.3"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T00:00:00Z","timestamp":1667520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006346","name":"Hope for Depression Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006346","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["4R00MH113821"],"award-info":[{"award-number":["4R00MH113821"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001381","name":"National Research Foundation Singapore","doi-asserted-by":"publisher","award":["MOH\u2010000504"],"award-info":[{"award-number":["MOH\u2010000504"]}],"id":[{"id":"10.13039\/501100001381","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acamh.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Child Psychology Psychiatry"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Experiences of early life adversity pose significant psychological and physical health risks to exposed individuals. Emerging evidence suggests that these health risks can be transmitted across generations; however, the mechanisms underlying the intergenerational impacts of maternal early\u2010life trauma on child health remain unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The current study used a prospective longitudinal design to determine the unique and joint contributions of maternal childhood trauma (neglect and abuse) and maternal prenatal and postnatal mental health (anxiety and depressive symptoms) (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u2009541) to children's resting frontoamygdala functional connectivity at 6\u2009years (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u200989) and emotional health at 7\u20138\u2009years, as indexed by parent\u2010reported internalizing problems and child self\u2010reported anxiety and depressive symptoms (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u2009268\u2013418).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Greater maternal childhood neglect was indirectly associated with greater internalizing problems serially through a pathway of worse maternal prenatal and postnatal mental health (greater maternal anxiety and depressive symptoms). Worse maternal postnatal mental health was also uniquely associated with more negative child frontoamygdala resting\u2010state functional connectivity, over and above maternal childhood trauma (both neglect and abuse) and prenatal mental health. More negative frontoamygdala functional connectivity was, in turn, associated with poorer child emotional health outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Findings from the current study provide support for the existence of intergenerational influences of parental exposure to childhood trauma on childhood risk for psychopathology in the next generation and point to the importance of maternal factors proximal to the second generation (maternal prenatal and postnatal mental health) in determining the intergenerational impact of maternal early experiences.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpp.13721","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T10:00:43Z","timestamp":1667556043000},"page":"426-436","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Effects of maternal childhood trauma on child emotional health: maternal mental health and frontoamygdala pathways"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7316-3562","authenticated-orcid":false,"given":"Jessica P.","family":"Uy","sequence":"first","affiliation":[{"name":"Department of Psychology University of California Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai Peng","family":"Tan","sequence":"additional","affiliation":[{"name":"Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research in Singapore  Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birit B.F.P.","family":"Broeckman","sequence":"additional","affiliation":[{"name":"Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research in Singapore  Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter D.","family":"Gluckman","sequence":"additional","affiliation":[{"name":"Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research in Singapore  Singapore City Singapore"},{"name":"Liggins Institute University of Auckland  Grafton, Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yap Seng","family":"Chong","sequence":"additional","affiliation":[{"name":"Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research in Singapore  Singapore City Singapore"},{"name":"Department of Paediatrics, Yong Loo Lin School of Medicine National University of Singapore  Singapore City Singapore"},{"name":"Department of Obstetrics and Gynaecology National University Health System  Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Chen","sequence":"additional","affiliation":[{"name":"Psychiatry and Radiology KK Women's and Children's Hospital  Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marielle V.","family":"Fortier","sequence":"additional","affiliation":[{"name":"Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research in Singapore  Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Meaney","sequence":"additional","affiliation":[{"name":"Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research in Singapore  Singapore City Singapore"},{"name":"Liggins Institute University of Auckland  Grafton, Auckland New Zealand"},{"name":"Department of Psychiatry, Douglas Hospital Research Centre McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridget L.","family":"Callaghan","sequence":"additional","affiliation":[{"name":"Department of Psychology University of California Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,4]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Manual for the ASEBA school\u2010age forms & profiles","author":"Achenbach T.M.","year":"2001"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2307\/1127388"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2134(02)00541-0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579419000488"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2019.02.001"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.204"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2021.09.046"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chiabu.2019.04.011"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2007.10.012"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10862-015-9492-z"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bht151"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0598-16.2016"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2020.01.024"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291720002147"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0956797614550878"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1307893110"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3446-12.2013"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2009.186"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2020.11.003"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2016.03.003"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.110.080499"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.11.001"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/cdev.13126"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118625392.wbecp419"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-200112000-00006"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2016.03.050"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199704000-00019"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.2277"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2017.07.009"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0499-06.2006"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2012.06751.x"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.13394"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.110.087734"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jecp.2010.08.006"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291712001298"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.114.156620"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/1359104517742186"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/1077559514527639"},{"key":"e_1_2_6_40_1","first-page":"3502","article-title":"VlPFC\u2010vmPFC\u2010amygdala interactions underlie age\u2010related differences in cognitive regulation of emotion","volume":"27","author":"Silvers J.A.","year":"2017","journal-title":"Cerebral Cortex"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23873"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyt125"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1177\/1524838020933870"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-45758-0_254"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2019.06.018"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copsyc.2017.06.012"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.01.035"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23129"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.22116"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhab081"}],"container-title":["Journal of Child Psychology and Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpp.13721","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcpp.13721","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acamh.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpp.13721","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T19:37:52Z","timestamp":1762198672000},"score":1,"resource":{"primary":{"URL":"https:\/\/acamh.onlinelibrary.wiley.com\/doi\/10.1111\/jcpp.13721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,4]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1111\/jcpp.13721"],"URL":"https:\/\/doi.org\/10.1111\/jcpp.13721","archive":["Portico"],"relation":{},"ISSN":["0021-9630","1469-7610"],"issn-type":[{"value":"0021-9630","type":"print"},{"value":"1469-7610","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,4]]},"assertion":[{"value":"2022-09-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}