{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T23:19:28Z","timestamp":1774480768503,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T00:00:00Z","timestamp":1677024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["K08MH129657"],"award-info":[{"award-number":["K08MH129657"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["K23DA048169"],"award-info":[{"award-number":["K23DA048169"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acamh.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Child Psychology Psychiatry"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:p>Early child neurodevelopment, including psychopathology, is influenced by a myriad of factors and interactions. These factors are both intrinsic to the caregiver\u2013child dyad such as genetics and epigenetics as well as extrinsic such as social environment and enrichment. Additional layers of complexity may be at play within families with parental substance use, as outlined by Conradt et al. (2023) in their review article titled \u201cPrenatal Opioid Exposure: A Two\u2010Generation Approach to Conceptualizing Risk for Child Psychopathology.\u201d. Conradt et al. provide an overarching synthesis of many findings related to substance use that goes beyond the in utero exposure to the transgenerational interface of pregnancy and early childhood, including biologic sensitivities such as genetic predisposition, overrepresentation of social risk factors including early adversities of caregivers and poverty, and transgenerational interactional susceptibilities. Altered dyadic interactions may relate to joint changes in neurobehavior and are not isolated from the influence of infant genetics, epigenetics, and environment. The early neurodevelopmental correlates of prenatal substance exposure including risks of childhood psychopathology are then a composite of many different forces. This nuanced reality, described as an \u201cinter\u2010generational cascade,\u201d does not centralize parental substance use or prenatal exposure as a singularly causative moment but positions it within the ecologic milieu of the total lived experience.<\/jats:p>","DOI":"10.1111\/jcpp.13770","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T06:14:37Z","timestamp":1677046477000},"page":"579-582","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Expansion and commentary on a two generation approach to prenatal opioid exposure \u2013 a commentary on Conradt et al. (2023)"],"prefix":"10.1111","volume":"64","author":[{"given":"Barbara H.","family":"Chaiyachati","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Perelman School of Medicine, and Leonard Davis Institute University of Pennsylvania  Philadelphia PA USA"},{"name":"Division of General Pediatrics, PolicyLab and Clinical Futures Children's Hospital of Philadelphia  Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davida","family":"Schiff","sequence":"additional","affiliation":[{"name":"Divisions of General Academic Pediatrics and Newborn Medicine MassGeneral for Children  Boston MA USA"},{"name":"Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2022.3396"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.13761"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h2102"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2021.12.021"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chiabu.2017.09.022"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40352-015-0015-5"},{"key":"e_1_2_7_8_1","volume-title":"Clinical guidance for treating pregnant and parenting women with opioid use disorder and their infants. 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