{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:08:19Z","timestamp":1789520899217,"version":"build-2803163510"},"reference-count":78,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T00:00:00Z","timestamp":1679443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006751","name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006751","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["SGR17\/001343"],"award-info":[{"award-number":["SGR17\/001343"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acamh.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Child Psychology Psychiatry"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Despite the numerous studies in favor of breastfeeding for its benefits in cognition and mental health, the long\u2010term effects of breastfeeding on brain structure are still largely unknown. Our main objective was to study the relationship between breastfeeding duration and cerebral gray matter volumes. We also explored the potential mediatory role of brain volumes on behavior.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed 7,860 magnetic resonance images of children 9\u201311\u2009years of age from the Adolescent Brain Cognitive Development (ABCD) dataset in order to study the relationship between breastfeeding duration and cerebral gray matter volumes. We also obtained several behavioral data (cognition, behavioral problems, prodromal psychotic experiences, prosociality, impulsivity) to explore the potential mediatory role of brain volumes on behavior.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the 7,860 children analyzed (median age\u00a0=\u00a09\u2009years and 11\u2009months; 49.9% female), whole\u2010brain voxel\u2010based morphometry analyses revealed an association mainly between breastfeeding duration and larger bilateral volumes of the pars orbitalis and the lateral orbitofrontal cortex. In particular, the association with the left pars orbitalis and the left lateral orbitofrontal cortex proved to be very robust to the addition of potentially confounding covariates, random selection of siblings, and splitting the sample in two. The volume of the left pars orbitalis and the left lateral orbitofrontal cortex appeared to mediate the relationship between breastfeeding duration and the negative urgency dimension of the UPPS\u2010P Impulsive Behavior Scale. Global gray matter volumes were also significant mediators for behavioral problems as measured with the Child Behavior Checklist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest that breastfeeding is a relevant factor in the proper development of the brain, particularly for the pars orbitalis and lateral orbitofrontal cortex regions. This, in turn, may impact impulsive personality and mental health in early puberty.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpp.13790","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T09:10:25Z","timestamp":1679476225000},"page":"1067-1079","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Breastfeeding duration is associated with larger cortical gray matter volumes in children from the\n                    <scp>ABCD<\/scp>\n                    study"],"prefix":"10.1111","volume":"64","author":[{"given":"Christian","family":"N\u00fa\u00f1ez","sequence":"first","affiliation":[{"name":"Mental Health Research Group Institut d'Investigaci\u00f3 Biom\u00e8dica Sant Pau (IIB Sant Pau), Hospital de la Santa Creu i Sant Pau  Barcelona 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Sant Joan de D\u00e9u, Esplugues de Llobregat  Barcelona Spain"},{"name":"Networking Research Center on Mental Health (CIBERSAM)  Madrid Spain"},{"name":"Pediatric Computational Imaging Group (PeCIC) Hospital Sant Joan de D\u00e9u, Esplugues de Llobregat  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,22]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Manual for the ASEBA School\u2010age Forms & Profiles: An integrated system of multi\u2010informant assessment","author":"Achenbach 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