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Developmental trajectories of ADHD and autistic traits both show heterogeneity in onset and course, but little is known about how symptom trajectories co\u2010develop into adulthood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using data from a population cohort, the Avon Longitudinal Study of Parents and Children, we examined correlations between ADHD and autistic traits across development, using the Social Communication Disorders Checklist and ADHD subscale of the Strengths and Difficulties Questionnaire. We modelled joint developmental trajectories of parent\u2010reported ADHD and autistic traits between 4 and 25\u2009years, then characterised trajectory classes based on sociodemographic, perinatal, psychopathology, cognition and social functioning variables and tested for associations with neurodevelopmental\/psychiatric polygenic scores (PGS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Three classes of trajectories were identified; a typically developing majority with low\u2010stable ADHD\u2010autistic traits (87%), a male\u2010predominant subgroup with child\/adolescent\u2010declining traits (6%) and a subgroup with late\u2010emerging traits (6%). ADHD\u2010autistic trait correlations were greatest in young adulthood for the two nontypically developing classes. There were higher rates of emotional and conduct problems, low IQ, childhood seizures and poor social functioning in the declining and late\u2010emerging classes compared to the low\u2010stable class. Emotional, conduct and peer problems were more prevalent during childhood in the childhood\/adolescent\u2010declining class compared to other classes, but were more prevalent in young adulthood in the late\u2010emerging class. Neurodevelopmental\/psychiatric PGS also differed: both nontypically developing classes showed elevated ADHD PGS compared to the low\u2010stable group, and the late\u2010emerging group additionally showed elevated schizophrenia PGS and decreased executive function PGS, whereas the declining group showed elevated broad depression PGS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Distinct patterns of ADHD\u2010autism co\u2010development are present across development in the general population, each with different characterising factors and genetic signatures as indexed by PGS.<\/jats:p>\n                  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