{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:07:33Z","timestamp":1792087653570,"version":"4.4.0"},"reference-count":66,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T00:00:00Z","timestamp":1696204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acamh.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Child Psychology Psychiatry"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The incidence of depression, anxiety, and post\u2010traumatic stress disorder (PTSD) among children and adolescents residing in low\u2010 and middle\u2010income countries (LMICs) poses a significant public health concern. However, there is variation in the evidence of effective psychological interventions. This meta\u2010analysis aims to provide a complete overview of the current body of evidence in this rapidly evolving field.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted searches on PubMed,\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/embase.com\">Embase.com<\/jats:ext-link>\n                      , and EBSCO\/APA PsycInfo databases up to June 23, 2022, identify randomized controlled trials (RCTs) investigating the effectiveness of psychological interventions in LMICs that targeted children and adolescents with elevated symptoms above a cut\u2010off score for depression, anxiety, and PTSD, comparing a psychological or psychosocial intervention with other control conditions. We conducted random effects meta\u2010analyses for depression, anxiety, and PTSD symptoms. Sensitivity analysis for outliers and high\u2010risk studies, and analyses for the publication bias were carried out. Subgroup analyses investigated how the intervention type, intervention format, the facilitator, study design, and age group of the participant predicted effect sizes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010one RCTs (6,123 participants) were included. We found a moderate effect of interventions on depression outcomes compared to the control conditions (\n                      <jats:italic>g<\/jats:italic>\n                      \u2009=\u20090.53; 95% CI: 0.06\u20130.99; NNT\u2009=\u20096.09) with a broad prediction interval (PI) (\u22121.8 to 2.86). We found a moderate to large effect for interventions on anxiety outcomes (\n                      <jats:italic>g<\/jats:italic>\n                      \u2009=\u20090.88; 95% CI: \u22120.03 to 1.79; NNT\u2009=\u20093.32) with a broad PI (\u22123.14 to 4.9). Additionally, a moderate effect was observed on PTSD outcomes (\n                      <jats:italic>g<\/jats:italic>\n                      \u2009=\u20090.54; 95% CI: 0.19\u20130.9; NNT\u2009=\u20095.86) with a broad PI (\u22120.64 to 1.72).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Psychological and psychosocial interventions aimed at addressing depression, anxiety, and PTSD among children and adolescents in LMICs have demonstrated promising results. However, future studies should consider the variation in evidence and incorporate long\u2010term outcomes to better understand the effectiveness of these interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpp.13891","type":"journal-article","created":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T05:04:01Z","timestamp":1696223041000},"page":"1776-1788","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Research Review: Psychological and psychosocial interventions for children and adolescents with depression, anxiety, and post\u2010traumatic stress disorder in low\u2010 and middle\u2010income countries \u2013 a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1981-4453","authenticated-orcid":false,"given":"Cansu","family":"Alozkan\u2010Sever","sequence":"first","affiliation":[{"name":"Department of Clinical, Neuro\u2010 and Developmental Psychology, WHO Collaborating Center for Research and Dissemination of Psychological Interventions, Amsterdam Public Health Research Institute Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana R.","family":"Uppendahl","sequence":"additional","affiliation":[{"name":"Chair of Social Pediatrics, TUM School of Medicine Technical University of Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pim","family":"Cuijpers","sequence":"additional","affiliation":[{"name":"Department of Clinical, Neuro\u2010 and Developmental Psychology, WHO Collaborating Center for Research and Dissemination of Psychological Interventions, Amsterdam Public Health Research Institute Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"de Vries","sequence":"additional","affiliation":[{"name":"Medical Library Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atif","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Primary Care and Mental Health, Institute of Population Health University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellenor","family":"Mittendorfer\u2010Rutz","sequence":"additional","affiliation":[{"name":"Division of Insurance Medicine, Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aemal","family":"Akhtar","sequence":"additional","affiliation":[{"name":"Division of Insurance Medicine, Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoli","family":"Zheng","sequence":"additional","affiliation":[{"name":"Faculty of Psychology and Educational Sciences KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marit","family":"Sijbrandij","sequence":"additional","affiliation":[{"name":"Department of Clinical, Neuro\u2010 and Developmental Psychology, WHO Collaborating Center for Research and Dissemination of Psychological Interventions, Amsterdam Public Health Research Institute Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1352465820000284"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/00207411.2021.1891361"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ebmental-2019-300117"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/10926771.2016.1231149"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/camh.12104"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2019.11.011"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.298.5.519"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3163\/1536-5050.104.3.014"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S2045796021000664"},{"key":"e_1_2_7_11_1","unstructured":"Cuijpers P. &Karyotaki E.(2020).A meta\u2010analytic database of randomised trials on psychotherapies for depression. Available from:https:\/\/doi.org\/10.17605\/OSF.IO\/825C6"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2019.4475"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.2000.00455.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000016495"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18168652"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/09638237.2020.1818702"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v69n0915"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10567-016-0202-5"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781003107347"},{"key":"e_1_2_7_21_1","unstructured":"Harrer M. Kuper P. Sprenger A. &Cuijpers P.(2022).metapsyTools: Several R helper functions for the \u201cMetapsy\u201d database. Available from:https:\/\/doi.org\/10.5281\/zenodo.6566632"},{"key":"e_1_2_7_22_1","volume-title":"Statistical methods for meta\u2010analysis","author":"Hedges L.V.","year":"1985"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-010247"},{"key":"e_1_2_7_24_1","unstructured":"ISTSS G.C. (2018).Posttraumatic stress disorder prevention and treatment guidelines methodology and recommendations. Available from:https:\/\/istss.org\/clinical\u2010resources\/treating\u2010trauma\/new\u2010istss\u2010prevention\u2010and\u2010treatment\u2010guidelines[last accessed July 2023]."},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajp.2016.07.011"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/00207411.2021.1891362"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2010.02209.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0251689"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2022.0301"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60827-1"},{"key":"e_1_2_7_31_1","volume-title":"Cochrane handbook for systematic reviews of interventions version 6.3 (updated February 2022)","author":"Lefebvre C.","year":"2022"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(20)30173-5"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1547"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00135"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.115.180265"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2015.0580"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000024350"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v10.i16.5306"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2021.1129"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beth.2019.09.005"},{"key":"e_1_2_7_41_1","unstructured":"Otten R. Vries R.D. &Schoonmade L.(2019).Amsterdam efficient deduplication (AED) method.Zenodo. Available from:https:\/\/doi.org\/10.5281\/zenodo.3582928"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-020-01630-4"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-116-1-78"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/camh.12083"},{"key":"e_1_2_7_45_1","article-title":"Psychological therapies for the treatment of mental disorders in low\u2010 and middle\u2010income countries affected by humanitarian crises","volume":"7","author":"Purgato M.","year":"2018","journal-title":"The Cochrane Database of Systematic Reviews"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(18)30046-9"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.09.053"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1177\/1178632917694350"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_378_18"},{"key":"e_1_2_7_50_1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.4103\/jehp.jehp_233_19","article-title":"Impact of holistic stress management program on academic stress and well\u2010being of Indian adolescent girls: A randomized controlled trial","volume":"8","author":"Rentala S.","year":"2019","journal-title":"Journal of Education Health Promotion"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291720002731"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.15540\/nr.9.1.29"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003887"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajp.2020.101970"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-005-0466-7"},{"key":"e_1_2_7_57_1","unstructured":"The World Bank. (2022).Classifying countries by income. World Development Indicators. Available from:https:\/\/datahelpdesk.worldbank.org\/knowledgebase\/articles\/906519\u2010world\u2010bank\u2010country\u2010and\u2010lending\u2010groups[last accessed February 2023]."},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wpsyc.2012.05.008"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-12-56"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.300.6.655"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2019.00933"},{"key":"e_1_2_7_62_1","article-title":"Primary\u2010level worker interventions for the care of people living with mental disorders and distress in low\u2010 and middle\u2010income countries","volume":"8","author":"Ginneken N.","year":"2021","journal-title":"The Cochrane Database of Systematic Reviews"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v036.i03"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-015-0024-z"},{"key":"e_1_2_7_65_1","volume-title":"World mental health report: Transforming mental health for all","author":"WHO","year":"2022"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajp.2017.10.029"},{"key":"e_1_2_7_67_1","first-page":"131","article-title":"Didactic therapy for management of stress and co\u2010morbid symptoms of depression and anxiety in Pakistani adolescents","volume":"30","author":"Zafar H.","year":"2015","journal-title":"Pakistan Journal of Psychological Research"}],"container-title":["Journal of Child Psychology and Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acamh.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpp.13891","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T19:15:45Z","timestamp":1762197345000},"score":1,"resource":{"primary":{"URL":"https:\/\/acamh.onlinelibrary.wiley.com\/doi\/10.1111\/jcpp.13891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,2]]},"references-count":66,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1111\/jcpp.13891"],"URL":"https:\/\/doi.org\/10.1111\/jcpp.13891","archive":["Portico"],"relation":{},"ISSN":["0021-9630","1469-7610"],"issn-type":[{"value":"0021-9630","type":"print"},{"value":"1469-7610","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,2]]},"assertion":[{"value":"2023-08-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}