{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:46:40Z","timestamp":1790138800765,"version":"4.0.1"},"reference-count":84,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T00:00:00Z","timestamp":1704240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["acamh.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Child Psychology Psychiatry"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cognitive\u2010behavioral therapy (CBT) and serotonin reuptake inhibitors (SRIs) are recommended treatments for pediatric obsessive\u2010compulsive disorder (OCD), but their relative efficacy and acceptability have not been comprehensively examined. Further, it remains unclear whether the efficacy of in\u2010person CBT is conserved when delivered in other formats, such as over telephone\/webcam or as Internet\u2010delivered CBT (ICBT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, PsycINFO, trial registries, and previous systematic reviews were searched for randomized controlled trials (RCTs) comparing CBT (in\u2010person, webcam\/telephone\u2010delivered, or ICBT) or SRIs with control conditions or each other. Network meta\u2010analyses were conducted to examine efficacy (post\u2010treatment Children's Yale\u2010Brown Obsessive Compulsive Scale) and acceptability (treatment discontinuation). Confidence in effect estimates was evaluated with CINeMA (Confidence in Network Meta\u2010Analysis).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty eligible RCTs and 35 contrasts comprising 2,057 youth with OCD were identified. In\u2010person CBT was significantly more efficacious than ICBT, waitlist, relaxation training, and pill placebo (MD range: 3.95\u201311.10; CINeMA estimate of confidence: moderate) but did not differ significantly from CBT delivered via webcam\/telephone (MD: 0.85 [\u22122.51, 4.21]; moderate), SRIs (MD: 3.07 [\u22120.07, 6.20]; low), or the combination of in\u2010person CBT and SRIs (MD: \u22121.20 [\u22125.29, 2.91]; low). SRIs were significantly more efficacious than pill placebo (MD: 4.59 [2.70, 6.48]; low) and waitlist (MD: 8.03 [4.24, 11.82]; moderate). No significant differences for acceptability emerged, but confidence in estimates was low.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In\u2010person CBT and SRIs produce clear benefits compared to waitlist and pill placebo and should be integral parts of the clinical management of pediatric OCD, with in\u2010person CBT overall having a stronger evidence base. The combination of in\u2010person CBT and SRIs may be most efficacious, but few studies hinder firm conclusions. The efficacy of CBT appears conserved when delivered via webcam\/telephone, while more trials evaluating ICBT are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpp.13934","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T20:56:04Z","timestamp":1704315364000},"page":"594-609","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Efficacy and acceptability of cognitive\u2010behavioral therapy and serotonin reuptake inhibitors for pediatric obsessive\u2010compulsive disorder: a network meta\u2010analysis"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1188-8706","authenticated-orcid":false,"given":"Matti","family":"Cervin","sequence":"first","affiliation":[{"name":"Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph 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