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The neural mechanism of VT and how past trauma history affects current VT remain largely unknown. This study aimed to identify neurobiological markers that track individual differences in VT and reveal the neural link between childhood cumulative trauma (CCT) and VT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We used structural and resting\u2010state functional magnetic resonance imaging before the pandemic to identify prospective brain markers for COVID\u2010related VT by correlating individuals' VT levels during the pandemic with the gray matter volume (GMV) and seed\u2010based resting\u2010state functional connectivity (RSFC) and examined how these brain markers linked CCT to VT in a sample of general young adults (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009115\/100).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Whole\u2010brain GMV\u2013behavior correlation analysis showed that VT was positively associated with GMV in the right dorsolateral prefrontal gyrus (DLPFC). Using the cluster derived from the GMV\u2013behavior correlation analysis as the seed region, we further revealed that the RSFC between the right DLPFC and right precuneus was negatively associated with VT. Importantly, the right DLPFC volume and DLPFC\u2010precuneus RSFC mediated the effect of CCT on VT. These findings remained unaffected by factors such as family socioeconomic status, other stressful life events, and general mental health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overall, our study presents structural and functional brain markers for\u00a0VT\u00a0and highlights these brain\u2010based markers as a potential neural mechanism linking CCT to COVID\u2010related VT,\u00a0which has implications for treating and preventing the development of trauma\u2010related mental disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpp.13989","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T08:07:40Z","timestamp":1713341260000},"page":"1407-1418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Brain structure and functional connectivity linking childhood cumulative trauma to\n                    <scp>COVID<\/scp>\n                    \u201019 vicarious traumatization"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0332-9023","authenticated-orcid":false,"given":"Xiqin","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Radiology West China Xiamen Hospital of Sichuan University  Xiamen China"},{"name":"Department of Radiology and Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital Sichuan University  Chengdu China"},{"name":"Research Unit of Psychoradiology Chinese Academy of Medical Sciences  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yajun","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Education and Psychology Southwest Minzu University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingguang","family":"Li","sequence":"additional","affiliation":[{"name":"College of Teacher Education Dali University  Dali China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueling","family":"Suo","sequence":"additional","affiliation":[{"name":"Department of Radiology and Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital Sichuan University  Chengdu China"},{"name":"Research Unit of Psychoradiology Chinese Academy of Medical Sciences  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiyong","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Radiology West China Xiamen Hospital of Sichuan University  Xiamen China"},{"name":"Department of Radiology and Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China 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