{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:07:46Z","timestamp":1792706866786,"version":"4.5.0"},"reference-count":66,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T00:00:00Z","timestamp":1730332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["K24 MH113737"],"award-info":[{"award-number":["K24 MH113737"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01 MH110445"],"award-info":[{"award-number":["R01 MH110445"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["T32 MH096679"],"award-info":[{"award-number":["T32 MH096679"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005197","name":"Hilda and Preston Davis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005197","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acamh.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Child Psychology Psychiatry"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Adolescence is a critical developmental period for the study of anorexia nervosa (AN), an illness characterized by extreme restriction of food intake. The maturation of the reward system during adolescence combined with recent neurobiological models of AN led to the hypothesis that early on in illness, restrictive food choices would be associated with activity in nucleus accumbens reward regions, rather than caudate regions identified among adults with AN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Healthy adolescents (HC,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200941) and adolescents with AN or atypical AN (atypAN,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200976) completed a Food Choice Task during fMRI scanning. Selection of high\u2010fat foods and choice\u2010related activation in nucleus accumbens and anterior caudate regions\u2010of\u2010interest (ROIs) were compared between individuals with AN\/atypAN and HC. Associations were examined between choice\u2010related activation and choice preferences among the AN group. Exploratory analyses examined associations between choice\u2010related activation and psychological assessments among the patient group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Adolescents with AN or atypAN selected fewer high\u2010fat foods than HC (\n                      <jats:italic>t<\/jats:italic>\n                      \u2009=\u2009\u22125.92,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001). Counter to predictions, there were no significant group differences in choice\u2010related activation in the ROIs. Among individuals with AN or atypAN, choice\u2010related neural activity in the anterior caudate was significantly negatively associated with high\u2010fat food selections in the task (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u2212.32,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.024). In exploratory analyses, choice\u2010related anterior caudate activation was positively associated with psychological measures of illness severity among patients (\n                      <jats:italic>p<\/jats:italic>\n                      's\u2009&lt;\u2009.05, uncorrected).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this large cohort of adolescents with AN\/atypAN, there was no evidence of altered reward system engagement during food choice. While there was no group difference in choice\u2010related caudate activation, the associations with choices and psychological measures continue to suggest that this neural region is implicated in illness. Longitudinal analyses will clarify whether neural variability relates to longer\u2010term course.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpp.14066","type":"journal-article","created":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T05:55:29Z","timestamp":1730354129000},"page":"378-389","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Food choice and neural reward systems in adolescents with anorexia nervosa and atypical anorexia nervosa"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4044-9550","authenticated-orcid":false,"given":"E. Caitlin","family":"Lloyd","sequence":"first","affiliation":[{"name":"Columbia University Irving Medical Center  New York NY USA"},{"name":"New York State Psychiatric Institute  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2704-1094","authenticated-orcid":false,"given":"Jonathan","family":"Posner","sequence":"additional","affiliation":[{"name":"Duke University  Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Schebendach","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center  New York NY USA"},{"name":"New York State Psychiatric Institute  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra F.","family":"Muratore","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center  New York NY USA"},{"name":"New York State Psychiatric Institute  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susie","family":"Hong","sequence":"additional","affiliation":[{"name":"Duke University  Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Ojeda","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center  New York NY USA"},{"name":"New York State Psychiatric Institute  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Rafanello","sequence":"additional","affiliation":[{"name":"Duke University  Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna E.","family":"Steinglass","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center  New York NY USA"},{"name":"New York State Psychiatric Institute  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Foerde","sequence":"additional","affiliation":[{"name":"University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.74"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22638"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1319762111"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0196-21"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2013.07.004"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1163\/156856897X00357"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2015.06.013"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.23699"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dr.2007.08.003"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23279"},{"key":"e_1_2_10_12_1","unstructured":"Chambers W. &Puig\u2010Antich J.(1978).Kiddie\u2010Sads\u2010Present and Lifetime Version (K\u2010SADS\u2010PL). 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