{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:28:15Z","timestamp":1790692095473,"version":"4.1.0"},"reference-count":91,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T00:00:00Z","timestamp":1730332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01\u2010MH106482"],"award-info":[{"award-number":["R01\u2010MH106482"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R37\u2010MH119194"],"award-info":[{"award-number":["R37\u2010MH119194"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R56\u2010MH119194"],"award-info":[{"award-number":["R56\u2010MH119194"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["T32\u2010MH 017119"],"award-info":[{"award-number":["T32\u2010MH 017119"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["T32 HD 104612\u20103"],"award-info":[{"award-number":["T32 HD 104612\u20103"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acamh.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Child Psychology Psychiatry"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The mechanisms linking early\u2010life adversity with psychopathology over the life\u2010course are complex. In this prospective study, we collectively examined cognitive, affective, and developmental mediators previously found to individually link childhood threat and deprivation experiences to adolescent psychopathology to identify the most potent mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data came from a community sample of 227 children (mean child age 11.5\u2009\u00b1\u20090.5\u2009years, 48.5% female) from the Seattle metro area with recruitment designed to reflect diversity in family income. Candidate mechanisms included self\u2010rated pubertal development and task\u2010measured attention bias to threat, emotion regulation, theory of mind, fear learning, inhibitory control, language ability, reasoning, and reward sensitivity. Using a high\u2010dimensional mediation approach, we determined which mediating pathways linking threat and deprivation to psychopathology persisted after controlling for all candidate mechanisms associated with psychopathology. Models additionally controlled for the child's age, sex, early\u2010childhood emotional and behavioral symptoms, poverty, and maternal depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Blunted reward sensitivity mediated the prospective relationship between threat and internalizing psychopathology, explaining 17.25% (95% CI 1.08%, 69.96%) of this association. Advanced pubertal development was associated with increases in internalizing and externalizing symptoms (standardized associations of 0.16 (95% CI 0.03, 0.29) and 0.17 (95% CI 0.05, 0.29), respectively), but not with adversity. Although deprivation was strongly related to psychopathology, no mechanisms were empirically identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In a well\u2010characterized community sample, we isolated reward sensitivity as a robust mediator of the prospective association between early\u2010life threat and adolescent internalizing psychopathology. Interventions aimed at bolstering reward sensitivity may mitigate the impact of early\u2010life threat experiences on internalizing problems.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpp.14067","type":"journal-article","created":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T03:20:03Z","timestamp":1730344803000},"page":"612-623","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Identifying cognitive, affective, and developmental mechanisms linking threat and deprivation with adolescent psychopathology"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2050-9475","authenticated-orcid":false,"given":"Ekaterina","family":"Sadikova","sequence":"first","affiliation":[{"name":"Department of Social and Behavioral Sciences Harvard T.H. Chan School of Public Health  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Weissman","sequence":"additional","affiliation":[{"name":"Department of Psychology Harvard University  Cambridge MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya L.","family":"Rosen","sequence":"additional","affiliation":[{"name":"Program in Neuroscience Smith College  Northampton MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Robinson","sequence":"additional","affiliation":[{"name":"Stanley Center for Psychiatric Research Broad Institute of MIT and Harvard  Cambridge MA USA"},{"name":"Center of Genomic Medicine and Department of Psychiatry Massachusetts General Hospital and Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8534-3982","authenticated-orcid":false,"given":"Liliana J.","family":"Lengua","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Washington  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret A.","family":"Sheridan","sequence":"additional","affiliation":[{"name":"Department of Psychology and Neuroscience University of North Carolina at Chapel Hill  Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4395-1397","authenticated-orcid":false,"given":"Henning","family":"Tiemeier","sequence":"additional","affiliation":[{"name":"Department of Social and Behavioral Sciences Harvard T.H. Chan School of Public Health  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1362-2410","authenticated-orcid":false,"given":"Katie A.","family":"McLaughlin","sequence":"additional","affiliation":[{"name":"Department of Psychology Harvard University  Cambridge MA USA"},{"name":"Ballmer Institute University of Oregon  Eugene OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,31]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Manual for the Child Behavior Checklist\/4\u201018 and 1991 profile","author":"Achenbach T.M.","year":"1991"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beth.2016.02.014"},{"key":"e_1_2_10_4_1","article-title":"The emotional stroop task: Assessing cognitive performance under exposure to emotional content","volume":"112","author":"Ben\u2010Haim M.S.","year":"2016","journal-title":"Journal of Visualized Experiments"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199703000-00012"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.1994.tb01284.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199704000-00018"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.12397"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/09297040903146966"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.818047"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/09567976221101045"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2022.101187"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1037\/bul0000270"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.13347"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/13803395.2019.1585519"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.74.4.658"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhm179"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.12.003"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9868.2008.00674.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chiabu.2004.11.001"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.13803"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12499"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/2167702618810518"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579419000725"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nss057"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579423000962"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/2167702620933570"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/1077559504269530"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.110.080499"},{"key":"e_1_2_10_31_1","first-page":"157","article-title":"Child abuse and automatic emotion regulation in children and adolescents","volume":"1","author":"Kim S.G.","year":"2021","journal-title":"Development and Psychopathology"},{"key":"e_1_2_10_32_1","volume-title":"Technical manual","author":"Kovacs M.","year":"2011"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579419000373"},{"key":"e_1_2_10_34_1","first-page":"200","article-title":"Reliability and validity of the Youth Self\u2010Report (YSR) of Achenbach's Child Behavior Checklist (CBCL)","volume":"11","author":"Liu X.","year":"1997","journal-title":"Chinese Mental Health Journal"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2019.00080"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04492-9"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.44.235.291"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.45.239.13"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/15374416.2014.979933"},{"key":"e_1_2_10_40_1","volume-title":"The Oxford handbook of stress and mental health","author":"McLaughlin K.","year":"2020"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/15374416.2015.1110823"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-020-01561-6"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2019.04.008"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.2277"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copsyc.2016.10.004"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/0963721416655883"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.365"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1177\/1745691621992346"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2014.10.012"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-devpsych-121318-084950"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adolescence.2021.04.010"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2011.08.003"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.13260"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1037\/abn0000331"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/sode.12025"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15327922par0402&3_8"},{"key":"e_1_2_10_57_1","volume-title":"Mplus user's guide: Statistical analysis with latent variables, user's guide","author":"Muth\u00e9n L.K.","year":"2017"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-023-02289-3"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2017.02.001"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1080\/15374416.2015.1118694"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chiabu.2022.105596"},{"key":"e_1_2_10_62_1","volume-title":"Income nonresponses in the current population survey","author":"Ono M.","year":"1969"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0018486"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2317"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2017.06.010"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579415000826"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1037\/0012-1649.36.5.679"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1177\/014662167700100306"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/1520-6629(200103)29:2<117::AID-JCOP1009>3.0.CO;2-2"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0193-3973(99)00020-9"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22610"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1037\/1528-3542.7.4.838"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.22318"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2014.09.001"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04381-8"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/desc.12934"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000001378"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-004-0048-2"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/jts.21780"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0054651"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2018.09.008"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2019.100700"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0031034"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1111\/cdep.12462"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291719001764"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11558-6"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbtep.2009.12.001"},{"key":"e_1_2_10_88_1","doi-asserted-by":"crossref","unstructured":"Wechsler D.(1999).Wechsler abbreviated scale of intelligence.","DOI":"10.1037\/t15170-000"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579419000348"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1177\/2167702620923649"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn_a_01825"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw351"}],"container-title":["Journal of Child Psychology and Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acamh.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpp.14067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T15:31:20Z","timestamp":1762183880000},"score":1,"resource":{"primary":{"URL":"https:\/\/acamh.onlinelibrary.wiley.com\/doi\/10.1111\/jcpp.14067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,31]]},"references-count":91,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/jcpp.14067"],"URL":"https:\/\/doi.org\/10.1111\/jcpp.14067","archive":["Portico"],"relation":{},"ISSN":["0021-9630","1469-7610"],"issn-type":[{"value":"0021-9630","type":"print"},{"value":"1469-7610","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,31]]},"assertion":[{"value":"2024-08-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}