{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:27:38Z","timestamp":1783607258480,"version":"3.55.0"},"reference-count":113,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T00:00:00Z","timestamp":1731974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["acamh.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Child Psychology Psychiatry"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fifteen million infants annually are born prematurely, placing them at high risk for life\u2010long adverse neurodevelopmental outcomes. Whether brain tissue abnormalities that accompany preterm birth persist into young adulthood and are associated with long\u2010term cognitive or psychiatric outcomes is not known.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From infancy into young adulthood, we followed a population\u2010based sample of consecutively identified preterm infants and their matched term controls. The preterm group was born at an average gestational age of 31.5\u2009\u00b1\u20092.6\u2009weeks. We obtained Diffusion Tensor Imaging scans and assessed cognitive and psychiatric outcomes in young adulthood, at a mean age of 19 (range 17.6\u201320.8) years. Usable data were acquired from 180 participants (89 preterm, 91 term).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Preterm birth was associated with lower fractional anisotropy (FA) and higher average diffusion coefficient (ADC) values in deep white matter tracts of the internal capsule, cerebral peduncles, inferior frontal\u2010occipital fasciculus, sagittal stratum and splenium of the corpus callosum, as well as in grey matter of the caudate, putamen and thalamus. A younger gestational age at birth accentuated these tissue abnormalities. Perinatal characteristics, including lower 5\u2010min APGAR score, history of bronchopulmonary dysplasia, more days of oxygen supplementation and multiple births all increased ADC values in deep white matter tracts and grey matter throughout the brain. Preterm individuals had significantly lower full\u2010scale IQ and more frequent lifetime psychiatric disorders. Those with psychiatric illnesses had significantly higher ADC and lower FA values throughout the deep posterior white matter.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Abnormalities in brain tissue microstructure associated with preterm birth persist into young adulthood and likely represent disordered myelination and accompanying axonal pathology. These disturbances are associated with a higher likelihood of developing a psychiatric disorder by young adulthood. Brain tissue disturbances were accentuated in those born at younger gestational ages and in those with a history of perinatal complications associated with infection and inflammation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpp.14069","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T19:34:51Z","timestamp":1732044891000},"page":"635-649","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Brain tissue microstructure in a prospective, longitudinal, population\u2010based cohort of preterm and term\u2010born young adults"],"prefix":"10.1111","volume":"66","author":[{"given":"Bradley S.","family":"Peterson","sequence":"first","affiliation":[{"name":"Institute for the Developing Mind Children's Hospital Los Angeles  Los Angeles CA USA"},{"name":"Department of Psychiatry Keck School of Medicine at the University of Southern California  Los Angeles CA 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