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Altered threat\u2010related information processing has been put forward as a potential process underlying the association between childhood adversity and psychiatric disorders, with previous research providing support for decreased discrimination between threat and safety cues, in both children and adults exposed to adversity. This altered threat\u2010safety discrimination has been hypothesized to stem from increased generalization of fear, yet to date, this hypothesis has not been tested in youth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Here, we investigate whether childhood adversity is associated with fear generalization during adolescence. 119 adolescents between 12 and 16\u2009years of age (mean\u2009=\u200913.95), of whom 63 exposed to childhood adversity, completed a fear generalization paradigm. Fear conditioning was assessed through trial\u2010by\u2010trial US expectancy ratings and post\u2010experimental ratings of fear, valence and arousal. Additionally, we administered a perceptual discrimination task to assess the potential impact of perceptual discrimination abilities upon fear generalization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In line with our hypotheses, results showed that childhood adversity is associated with (1) reduced threat\u2010safety differentiation during fear acquisition and (2) increased fear generalization in both boys and girls, albeit to a different extent, as boys showed more generalization towards safety cues while girls showed more generalization towards dangerous cues. Moreover, this overgeneralization of fear could not be attributed to group differences in perceptual discrimination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Altered fear learning may be an important process through which adversity increases risk for the development of psychopathology. Longitudinal research is essential to elucidate risk and resilience patterns following childhood adversity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpp.14092","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T05:08:17Z","timestamp":1734066497000},"page":"821-833","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Childhood adversity is associated with reduced threat\u2010safety discrimination and increased fear generalization in 12\u2010 to 16\u2010year\u2010olds"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0032-7962","authenticated-orcid":false,"given":"Celine","family":"Samaey","sequence":"first","affiliation":[{"name":"Clinical Psychiatry KU Leuven  Leuven Belgium"},{"name":"BRAMlab, KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Lecei","sequence":"additional","affiliation":[{"name":"Clinical Psychiatry KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"Jackers","sequence":"additional","affiliation":[{"name":"Clinical Psychiatry KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise","family":"Jennen","sequence":"additional","affiliation":[{"name":"Clinical Psychiatry KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen","family":"Schruers","sequence":"additional","affiliation":[{"name":"Mechanisms of Affective Disorders Lab Maastricht University  Maastricht The Netherlands"},{"name":"Health Psychology KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bram","family":"Vervliet","sequence":"additional","affiliation":[{"name":"BRAMlab, KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Boets","sequence":"additional","affiliation":[{"name":"Developmental Psychiatry KU Leuven  Leuven Belgium"},{"name":"Leuven Autism Research KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruud","family":"van Winkel","sequence":"additional","affiliation":[{"name":"Clinical Psychiatry KU Leuven  Leuven Belgium"},{"name":"University Psychiatric Center KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbx161"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v067.i01"},{"key":"e_1_2_10_4_1","volume-title":"Assessment of family violence: A handbook for researchers and practitioners","author":"Bernstein D.P.","year":"1998"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-7916(94)90063-9"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-022-01332-2"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2009.02.035"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41562-020-0880-3"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/09658211.2014.886704"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579421001838"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.06.019"},{"key":"e_1_2_10_12_1","volume-title":"The Juvenile Victimization Questionnaire: 2nd Revision (JVQ\u2010R2)","author":"Finkelhor D.","year":"2011"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chiabu.2004.11.001"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.13803"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2019.03.008"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2017.03.010"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2012.09.006"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40653-022-00443-8"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.110.080499"},{"key":"e_1_2_10_20_1","doi-asserted-by":"crossref","unstructured":"Klingelh\u00f6fer\u2010Jens M. 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