{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T18:46:22Z","timestamp":1786387582515,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/P017355\/1"],"award-info":[{"award-number":["MR\/P017355\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["SUAG\/043 G101400"],"award-info":[{"award-number":["SUAG\/043 G101400"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acamh.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Child Psychology Psychiatry"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Effective face\u2010to\u2010face treatments for Post\u2010Traumatic Stress Disorder (PTSD) are available, but most young people with PTSD do not receive effective treatment. Therapist\u2010supported online Cognitive Therapy has the potential to improve accessibility of effective treatment. This early\u2010stage trial gathered data on the feasibility, acceptability, and initial signal of clinical efficacy of a novel online Cognitive Therapy program for young people with PTSD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A two\u2010arm, parallel\u2010groups, single\u2010blind, early\u2010stage feasibility RCT compared online Cognitive Therapy to a waitlList condition. Participants were\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200931 adolescents (12\u201317\u2009years\u2010old) with a diagnosis of PTSD, randomised in a 1:1 ratio using minimisation. Thresholds for progression to a larger trial were set a priori for recruitment rate, data completeness, and the initial signal of clinical efficacy. The primary clinical outcome was PTSD diagnosis at 16\u2009weeks post\u2010randomisation. Secondary clinical outcomes were continuous measures of PTSD, depression, and anxiety at 16\u2009weeks; and at 38\u2009weeks in the online Cognitive Therapy arm.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All pre\u2010determined feasibility thresholds for progression to a larger trial were met. We recruited to target at a rate of 1\u20132 participants\/month. No patient dropped out of therapy; 94% of all participants were retained at 16\u2009weeks. At 16\u2010weeks, the intention\u2010to\u2010treat (ITT) effect adjusted odds ratio was 0.20 (95% CI, 0.02, 1.42), indicating that the odds of meeting PTSD caseness after online therapy were 80% lower than after the waitlist (10\/16 participants met PTSD caseness after therapy compared to 11\/13 after WL). Effect\u2010size estimates for all secondary clinical outcomes were large\u2010moderate; improvements were sustained 38\u2009weeks after online Cognitive Therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Therapist\u2010supported online Cognitive Therapy for PTSD is acceptable to young people and has potential for meaningful and sustained clinical effects. A larger trial appears feasible to deliver. Further work is needed to refine the intervention and its delivery and to evaluate it in a larger confirmatory trial.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpp.14124","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T01:43:02Z","timestamp":1738892582000},"page":"1117-1128","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Early\u2010stage randomised controlled trial of therapist\u2010supported online cognitive therapy for post\u2010traumatic stress disorder in young people"],"prefix":"10.1111","volume":"66","author":[{"given":"Patrick","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Psychology Institute of Psychiatry, Psychology and Neuroscience, King's College London  London UK"},{"name":"South London &amp; Maudsley NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Ehlers","sequence":"additional","affiliation":[{"name":"Department of Experimental Psychology University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewan","family":"Carr","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Health Informatics Institute of Psychiatry, Psychology and Neuroscience, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Experimental Psychology University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Dalgleish","sequence":"additional","affiliation":[{"name":"Medical Research Council Cognition and Brain Sciences Unit University of Cambridge  Cambridge UK"},{"name":"Cambridgeshire and Peterborough NHS Foundation Trust  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Forbes","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Health Informatics Institute of Psychiatry, Psychology and Neuroscience, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberley","family":"Goldsmith","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Health Informatics Institute of Psychiatry, Psychology and Neuroscience, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Griffiths","sequence":"additional","affiliation":[{"name":"Department of Psychology Institute of Psychiatry, Psychology and Neuroscience, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Psychology Institute of Psychiatry, Psychology and Neuroscience, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothy","family":"King","sequence":"additional","affiliation":[{"name":"Department of Psychology Institute of Psychiatry, Psychology and Neuroscience, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Miles","sequence":"additional","affiliation":[{"name":"Department of Psychology Institute of Psychiatry, Psychology and Neuroscience, King's College London  London UK"},{"name":"South London &amp; Maudsley NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic T.","family":"Plant","sequence":"additional","affiliation":[{"name":"Department of Psychology Institute of Psychiatry, Psychology and Neuroscience, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology and Psychological Therapies, Norwich Medical School University of East Anglia  Norwich UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jess","family":"Steward","sequence":"additional","affiliation":[{"name":"Department of Psychology Institute of Psychiatry, Psychology and Neuroscience, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Yule","sequence":"additional","affiliation":[{"name":"Department of Psychology Institute of Psychiatry, Psychology and Neuroscience, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0262-623X","authenticated-orcid":false,"given":"Richard","family":"Meiser\u2010Stedman","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology and Psychological Therapies, Norwich Medical School University of East Anglia  Norwich UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-047600"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.13258"},{"key":"e_1_2_10_4_1","unstructured":"Child Outcome Research Consortium (CORC). 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