{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T18:01:50Z","timestamp":1788026510783,"version":"build-2784847793"},"reference-count":86,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01\u2010042747"],"award-info":[{"award-number":["R01\u2010042747"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01\u201007957"],"award-info":[{"award-number":["R01\u201007957"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acamh.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Child Psychology Psychiatry"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Few studies have examined the intergenerational impact of maternal childhood maltreatment (MCM) in the context of prenatal substance exposure (PSE). This study investigates whether PSE is part of the pathway of MCM or an independent risk factor affecting offspring psychopathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants were 284 birth mother\u2013child (44% male) dyads, primarily Black, low\u2010income, enrolled at birth. Exposure to alcohol, tobacco, marijuana, or cocaine in utero was assessed at 1\u2009month postpartum. MCM was assessed at child age 4, and maternal psychological distress and offspring maltreatment at child age 10. Mother\u2010 and child\u2010reported internalizing and externalizing symptoms were assessed at child age 12 using the Child Behavior Checklist and the Youth Self\u2010Report. Structural equation modeling was conducted to test sequential mediation pathways examining the direct and indirect associations of MCM with child internalizing and externalizing symptoms via PSE, maternal psychological distress, and offspring maltreatment, adjusting for covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MCM was directly related to adolescent\u2010reported internalizing and externalizing symptoms, whereas PSE was directly related to adolescent\u2010reported externalizing symptoms. MCM and PSE were indirectly related to mother\u2010reported internalizing and externalizing symptoms via maternal psychological distress. Only PSE was related to offspring maltreatment at 10\u2009years, and offspring maltreatment was related to both mother\u2010 and adolescent\u2010reported internalizing and externalizing symptoms at 12\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MCM and PSE may increase offspring vulnerability to psychopathology, highlighting the importance of evaluating historical risks that mothers may transmit from their own childhood maltreatment and prenatal substance use in assessing offspring psychopathology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpp.70030","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T07:59:22Z","timestamp":1754985562000},"page":"171-182","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Intergenerational transmission of 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