{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:12:27Z","timestamp":1785323547820,"version":"3.55.0"},"reference-count":51,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018775","name":"Danish Foundation TrygFonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018775","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acamh.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Child Psychology Psychiatry"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Credible long\u2010term outcomes from randomized trials evaluating the effectiveness and cost\u2010effectiveness of preventive programs for mental health problems are needed. We compared long\u2010term effects of the Mind My Mind (MMM) transdiagnostic cognitive behavioral therapy (CBT) program to management as usual (MAU).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study was a pragmatic, multisite, randomized superiority trial (2017\u20132019) involving youths aged 6\u201316\u2009years with anxiety, depressive symptoms, and\/or behavioral disturbances, recruited through family self\u2010referral. The MMM intervention included 9\u201313 weekly CBT sessions. The primary outcome was change from baseline in parent\u2010reported impact of mental health problems at 3\u2010year follow\u2010up post\u2010randomization using the Strengths and Difficulties Questionnaire (SDQ) impact scale. Register\u2010based outcomes tracked youths' psychiatric diagnoses in mental health services. To assess cost\u2010effectiveness, we calculated the incremental costs and incremental quality\u2010adjusted life years (QALYs). All primary analyses followed the intention\u2010to\u2010treat (ITT) approach. Clinical trials registration: ID NCT04804917.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 396 youths randomized (baseline mean [\n                      <jats:italic>SD<\/jats:italic>\n                      ] age, 10.3\u2009[2.4] years; 52.0% boys; MMM\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009197, MAU\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009199), the 3\u2010year follow\u2010up (median 167\u2009weeks; range 124\u2013203\u2009weeks) primary outcome data were available in 69.0% and 59.3%, respectively. The decrease in SDQ\u2010impact\u2010score from baseline to 3\u2010year follow\u2010up (4.12\u21921.79 points [MMM] and 4.21\u21921.85 [MAU]) was similar (between\u2010group difference, 0.06 [95% CI \u22120.41 to 0.52];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.81). An equal proportion (25%) of youths in MMM and MAU were diagnosed with any mental disorder during follow\u2010up (HR 1.01, 95% CI 0.68\u20131.50). Total costs over the intervention period were higher in the MMM group (incremental costs 3,014 Euros [95% CI: 2.174\u20133.855]). Cost\u2010effectiveness analyses favored MMM: QALY net gain 0.121 (95% CI 0.045\u20130.196); the cost\u2010effectiveness ratio was 24,789 Euro\/QALY.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although MMM was potentially cost\u2010effective, the beneficial effects diminished over 3\u2009years post\u2010treatment. The findings highlight the need for strategies to sustain long\u2010term effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpp.70128","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:52:00Z","timestamp":1773013920000},"page":"1307-1320","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Outcome and cost\u2010effectiveness of transdiagnostic cognitive behavioral therapy compared with management as usual for youth with common mental health problems: Long\u2010term results from the Mind\u2010My\u2010Mind randomized trial"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6298-4146","authenticated-orcid":false,"given":"Ditte","family":"Vassard","sequence":"first","affiliation":[{"name":"Child and Adolescent Mental Health Center, Copenhagen University Hospital \u2013 Mental Health Services CPH  Copenhagen 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Lausanne University Hospital CHUV and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Verhulst","sequence":"additional","affiliation":[{"name":"Child and Adolescent Mental Health Center, Copenhagen University Hospital \u2013 Mental Health Services CPH  Copenhagen Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences, University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Child Psychiatry\/Psychology Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Bilenberg","sequence":"additional","affiliation":[{"name":"Department for Child and Adolescent Psychiatry Mental Health Services in the Region of Southern Denmark  Odense Denmark"},{"name":"University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per Hove","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Research Center at Department for Child and Adolescent Psychiatry Aarhus University Hospital  Skejby Denmark"},{"name":"Institute of Clinical Medicine, Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Thastum","sequence":"additional","affiliation":[{"name":"Department of Psychology and Behavioural Science Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon\u2010Peter","family":"Neumer","sequence":"additional","affiliation":[{"name":"Centre for Child and Adolescent Mental Health  Oslo Norway"},{"name":"The Arctic University of Norway, Centre for Child and Youth Mental Health and Child Welfare, North Norway (RKBU North)  Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Katrine","family":"Pagsberg","sequence":"additional","affiliation":[{"name":"Child and 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