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The aim of this study was to evaluate the school\u2010based internet intervention\n                      <jats:italic>StresSOS<\/jats:italic>\n                      for the universal prevention of mental illnesses in youth.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A two\u2010arm, randomized controlled trial was conducted. Participants were recruited from schools across five regions of Germany. Young people between the ages of 12 and 25\u2009years without mental health problems were invited to the trial and randomly assigned to\n                      <jats:italic>StresSOS<\/jats:italic>\n                      or to the attention placebo control condition, stratified by sex. Participants in both conditions received eight web\u2010based sessions with information and exercises and weekly e\u2010mail teasers about program content and a monitoring survey.\n                      <jats:italic>StresSOS<\/jats:italic>\n                      comprised content on life skills, particularly stress management and mental health literacy, and the control condition content comprised healthy nutrition. The primary outcome was self\u2010reported mental health status at a 12\u2010month follow\u2010up. Intention\u2010to\u2010treat analyses were calculated. The trial was preregistered with the German Register of Clinical Trials (DRKS00014693, see\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/drks.de\/search\/en\/trial\/DRKS00014693\">https:\/\/drks.de\/search\/en\/trial\/DRKS00014693<\/jats:ext-link>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 5,268 eligible students were invited to participate, 2,327 (44%) activated their account and were randomized to\n                      <jats:italic>StresSOS<\/jats:italic>\n                      (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091,154) or to the control condition (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091,173). Due to COVID\u201019\u2010related school closures, 1,209 were lost to follow\u2010up, and data from 1,118 students were analyzed (535 in\n                      <jats:italic>StresSOS<\/jats:italic>\n                      and 583 in the control group). Participation in\n                      <jats:italic>StresSOS<\/jats:italic>\n                      led to significantly reduced incidences of emerging mental health problems at the 12\u2010month follow\u2010up (controls:\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009162 [28%] \u2018with problems\u2019;\n                      <jats:italic>StresSOS<\/jats:italic>\n                      :\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009113 [21%] \u2018with problems\u2019; OR 0.70, 95% CI [0.52, 0.92],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>StresSOS<\/jats:italic>\n                      was effective in universally preventing the onset of mental health problems, with a small effect. Internet interventions have the potential to contribute to a reduction of the disease burden in young people.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpp.70145","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T08:25:08Z","timestamp":1773390308000},"page":"1393-1403","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of the school\u2010based internet intervention\n                    <i>StresSOS<\/i>\n                    for the prevention of mental health problems in young people: a randomized controlled trial as part of the\n                    <scp>ProHEAD<\/scp>\n                    consortium"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3881-3632","authenticated-orcid":false,"given":"Laya","family":"Lehner","sequence":"first","affiliation":[{"name":"Department of Educational 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