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This review aimed to catalog crossover effects of family\u2010centered prevention programs (FCPP). The authors searched prevention program registries, screened 2,556 prevention programs (including duplicates across registries), and reviewed 166 programs against inclusion criteria. Of these 24 FCPPs with crossover effects were cataloged. Seven crossover domains (internalizing, externalizing, suicidal thoughts and behaviors, physical health, academics, high\u2010risk sexual behaviors, and parental depression) were reviewed. Fourteen of the 24 reviewed programs yielded evidence of significant main effects on at least one crossover domain, with several yielding evidence across multiple crossover domains. Understanding the full breadth and reach of preventive interventions, including crossover effects, can increase efficiency and cost\u2010effectiveness of prevention strategies. Most programs reviewed reported more than one crossover effect, and many others are encouraged to test the data for additional benefits. New data harmonization techniques can assist with low base\u2010rate outcomes and smaller subgroup restrictions. Finally, more mechanistic and longitudinal investigations are needed to effectively leverage the FCPPs with the most widespread crossover effects.<\/jats:p>","DOI":"10.1111\/jcpp.70221","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T12:44:36Z","timestamp":1786711476000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Annual Research Review: Beyond the target \u2013 understanding crossover effects in family\u2010centered prevention"],"prefix":"10.1111","author":[{"given":"Arin M.","family":"Connell","sequence":"first","affiliation":[{"name":"Department of Psychological Sciences Case Western Reserve University  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Epstein","sequence":"additional","affiliation":[{"name":"Social Development Research Group, School of Social Work University of Washington  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"McClaine","sequence":"additional","affiliation":[{"name":"Department of Psychological Sciences Case Western Reserve University  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karryn","family":"Satchell","sequence":"additional","affiliation":[{"name":"Social Development Research Group, School of Social Work University of Washington  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Halvorson","sequence":"additional","affiliation":[{"name":"Social Development Research Group, School of Social Work University of Washington  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Mariscal","sequence":"additional","affiliation":[{"name":"Social Development Research Group, School of Social Work University of Washington  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11121-024-01759-7","article-title":"Crossover effects of PROSPER on young adult suicide risk: The role of adolescent belongingness to family and school","volume":"26","author":"Bai S.","year":"2025","journal-title":"Prevention Science"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1037\/0893-3200.22.2.241","article-title":"Change in caregiver depression as a function of the strong African American families program","volume":"22","author":"Beach S.","year":"2008","journal-title":"Family Psychology"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1007\/s00787-017-1053-4","article-title":"Conduct problems trajectories and psychosocial outcomes: A systematic review and meta\u2010analysis","volume":"27","author":"Bevilacqua L.","year":"2018","journal-title":"European Child & Adolescent Psychiatry"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1007\/s11121-021-01247-2","article-title":"Familias Unidas prevents youth internalizing symptoms: A baseline target moderated mediation (BTMM) study","volume":"24","author":"Brincks A.","year":"2023","journal-title":"Prevention Science"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s11121-016-0666-z","article-title":"Preventing youth internalizing symptoms through the Familias Unidas intervention: Examining variation in response","volume":"19","author":"Brincks A.","year":"2018","journal-title":"Prevention Science"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/jcpp.12495","article-title":"Family\u2010centered prevention ameliorates the longitudinal association between risky family processes and epigenetic aging","volume":"57","author":"Brody G.","year":"2016","journal-title":"Journal of Child Psychology and Psychiatry, and Allied Disciplines"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/jcpp.12968","article-title":"Preventive parenting intervention during childhood and young black adults' unhealthful behaviors: A randomized controlled trial","volume":"60","author":"Brody G.","year":"2019","journal-title":"Journal of Child Psychology and Psychiatry, and Allied Disciplines"},{"key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"e621","DOI":"10.1542\/peds.2011-1568","article-title":"Early childhood family intervention and long\u2010term obesity prevention among high\u2010risk minority youth","volume":"129","author":"Brotman L.","year":"2012","journal-title":"Pediatrics"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1017\/S0954579400005605","article-title":"Co\u2010occurrence of conduct problems and depressive symptoms in early adolescent boys: II. 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