{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:50:14Z","timestamp":1791607814074,"version":"4.3.4"},"reference-count":71,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515010619"],"award-info":[{"award-number":["2022A1515010619"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2025A1515010630"],"award-info":[{"award-number":["2025A1515010630"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acamh.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Child Psychology Psychiatry"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Self\u2010injurious thoughts and behaviors (SITB) represent a significant mental health issue among Chinese adolescents. Research on smartphone\u2010based safety planning as digital therapeutics for SITB in China remains limited. This randomized controlled trial evaluated the efficacy and acceptability of a safety planning mobile application (LIFES) for reducing SITB in adolescents with depressive episodes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Among 189 adolescents with depressive episodes screened, 122 were randomized to either the intervention group (LIFES app plus treatment as usual [TAU],\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200961) or the control group (TAU only,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200961). Follow\u2010up assessments at 1, 3, and 6\u2009months measured SITB, depression, anxiety, and sleep quality. This trial is registered with the Chinese Clinical Trial Registry (ChiCTR2300075663;\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.chictr.org.cn\/\">https:\/\/www.chictr.org.cn\/<\/jats:ext-link>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Generalized linear mixed models showed significant time\u2010by\u2010group interaction effects for non\u2010suicidal self\u2010injury frequency (\n                      <jats:italic>F<\/jats:italic>\n                      \u2009=\u20093.39,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.018), suicide planning seriousness (\n                      <jats:italic>F<\/jats:italic>\n                      \u2009=\u20092.93,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.034), confidence in suicide completion during preparation (\n                      <jats:italic>F<\/jats:italic>\n                      \u2009=\u20093.10,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.027), suicide threat\/gesture frequency (\n                      <jats:italic>F<\/jats:italic>\n                      \u2009=\u20093.64,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.013), and total suicidal behavior frequency (\n                      <jats:italic>F<\/jats:italic>\n                      \u2009=\u20093.31,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.020) after adjusting for depression and anxiety symptom severity, sleep quality, and years of education. The intervention group showed significantly greater reductions in SITB characteristics compared to the control group. User experience surveys indicated good satisfaction with the application.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study demonstrates that safety planning\u2010based digital therapeutics are an effective adjunctive intervention for SITB in adolescents with depressive episodes. Future research should examine the applicability of this intervention to broader populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpp.70246","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:30:55Z","timestamp":1791606655000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and acceptability of digital safety planning therapy for self\u2010injurious thoughts and behaviors in adolescents with depressive episodes: a randomized controlled trial"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6618-3142","authenticated-orcid":false,"given":"Yi\u2010Hui","family":"Liu","sequence":"first","affiliation":[{"name":"Guangdong Mental Health Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Rong","family":"Liang","sequence":"additional","affiliation":[{"name":"Guangdong Mental Health Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Southern Medical University  Guangzhou China"},{"name":"The Third People's Hospital of Zhuhai  Zhuhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Jia","family":"Yang","sequence":"additional","affiliation":[{"name":"Guangdong Mental Health Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin\u2010Cheng\u2010Cheng","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangdong Mental Health Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin\u2010Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Mental Health Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Southern Medical University  Guangzhou China"},{"name":"Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Ni","family":"Wen","sequence":"additional","affiliation":[{"name":"Guangdong Mental Health Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu\u2010Jun","family":"Jia","sequence":"additional","affiliation":[{"name":"Guangdong Mental Health Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7789-5602","authenticated-orcid":false,"given":"Cai\u2010Lan","family":"Hou","sequence":"additional","affiliation":[{"name":"Guangdong Mental Health Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1111\/jpm.12928","article-title":"Suicide prevention: What does the evidence show for the effectiveness of safety planning for children and young people? \u2013 A systematic scoping review","volume":"30","author":"Abbott\u2010Smith S.","year":"2023","journal-title":"Journal of Psychiatric and Mental Health Nursing"},{"key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1001\/jamapediatrics.2025.1012","article-title":"Safety planning interventions for suicide prevention in children and adolescents: A systematic review and meta\u2010analysis","volume":"179","author":"Albaum C.","year":"2025","journal-title":"JAMA Pediatrics"},{"key":"e_1_2_12_4_1","unstructured":"American Academy of Pediatrics. 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