{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T11:45:25Z","timestamp":1774352725562,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,11,5]],"date-time":"2013-11-05T00:00:00Z","timestamp":1383609600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2013,11,5]],"date-time":"2013-11-05T00:00:00Z","timestamp":1383609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pharm Ther"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1111\/jcpt.12105","type":"journal-article","created":{"date-parts":[[2013,11,5]],"date-time":"2013-11-05T09:12:12Z","timestamp":1383642732000},"page":"91-96","source":"Crossref","is-referenced-by-count":30,"title":["N-acetyltransferase 2, cytochrome P4502E1 and glutathione S-transferase genotypes in antitubercular treatment-induced hepatotoxicity in North Indians"],"prefix":"10.1155","volume":"39","author":[{"given":"S. V.","family":"Rana","sequence":"first","affiliation":[{"name":"Department of Super Specialty Gastroenterology; Post Graduate Institute of Medical Education & Research; Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. K.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Super Specialty Gastroenterology; Post Graduate Institute of Medical Education & Research; Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. P.","family":"Ola","sequence":"additional","affiliation":[{"name":"Department of Super Specialty Gastroenterology; Post Graduate Institute of Medical Education & Research; Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. K.","family":"Kamboj","sequence":"additional","affiliation":[{"name":"Department of Super Specialty Gastroenterology; Post Graduate Institute of Medical Education & Research; Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Super Specialty Gastroenterology; Post Graduate Institute of Medical Education & Research; Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. K.","family":"Morya","sequence":"additional","affiliation":[{"name":"Department of Super Specialty Gastroenterology; Post Graduate Institute of Medical Education & Research; Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. K.","family":"Sinha","sequence":"additional","affiliation":[{"name":"Department of Super Specialty Gastroenterology; Post Graduate Institute of Medical Education & Research; Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,5]]},"reference":[{"key":"10.1111\/jcpt.12105-BIB0001|jcpt12105-cit-0001","unstructured":"WHO - World Health Organization 2008 Global Tuberculosis Control. WHO Report 2008"},{"key":"10.1111\/jcpt.12105-BIB0002|jcpt12105-cit-0002","unstructured":"World Health Organization Actions for Life Towards a World Free of Tuberculosis: The Global Plan to Stop TB 2006-2015.WHO\/HTM\/STB\/2006.35 World Health Organization Geneva, Switzerland"},{"key":"10.1111\/jcpt.12105-BIB0003|jcpt12105-cit-0003","unstructured":"World Health Organization Guidelines for the Programmatic Management of Drug-resistant Tuberculosis. WHO\/HTM\/STB\/2006.361 World Health Organization Geneva, Switzerland"},{"key":"10.1111\/jcpt.12105-BIB0004|jcpt12105-cit-0004","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1111\/j.1440-1746.2005.04048.x","article-title":"Monitoring and management of antituberculosis drug induced hepatotoxicity","volume":"20","author":"Agal","year":"2005","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1111\/jcpt.12105-BIB0005|jcpt12105-cit-0005","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1053\/jhep.2002.32102","article-title":"Polymorphism of the N-acetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatitis","volume":"35","author":"Huang","year":"2002","journal-title":"Hepatology"},{"key":"10.1111\/jcpt.12105-BIB0006|jcpt12105-cit-0006","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/S0140-6736(03)14333-4","article-title":"Tuberculosis","volume":"362","author":"Frieden","year":"2003","journal-title":"Lancet"},{"key":"10.1111\/jcpt.12105-BIB0007|jcpt12105-cit-0007","doi-asserted-by":"crossref","first-page":"5237","DOI":"10.1073\/pnas.88.12.5237","article-title":"Molecular mechanism of slow acetylation of drugs and carcinogens in humans","volume":"88","author":"Blum","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/jcpt.12105-BIB0008|jcpt12105-cit-0008","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1053\/jhep.2003.50144","article-title":"Cytochrome P450 2E1 genotype and the susceptibility to anti-tuberculosis drug-induced hepatitis","volume":"37","author":"Huang","year":"2003","journal-title":"Hepatology"},{"key":"10.1111\/jcpt.12105-BIB0009|jcpt12105-cit-0009","doi-asserted-by":"crossref","first-page":"181","DOI":"10.7326\/0003-4819-84-2-181","article-title":"Isoniazid liver injury: clinical spectrum, pathology, and probable pathogenesis","volume":"84","author":"Mitchell","year":"1976","journal-title":"Ann Intern Med"},{"key":"10.1111\/jcpt.12105-BIB0010|jcpt12105-cit-0010","first-page":"734","article-title":"Effects of hydrazine, phenelzine, and hydralazine treatment on rat hepatic and renal drug-metabolizing enzyme expression","volume":"24","author":"Runge-Morris","year":"1996","journal-title":"Drug Metab Dispos"},{"key":"10.1111\/jcpt.12105-BIB0011|jcpt12105-cit-0011","first-page":"1072","article-title":"Rifampin-induced release of hydrazine from isoniazid. A possible cause of hepatitis during treatment of tuberculosis with regimens containing isoniazid and rifampin","volume":"133","author":"Sarma","year":"1986","journal-title":"Am Rev Respir Dis"},{"key":"10.1111\/jcpt.12105-BIB0012|jcpt12105-cit-0012","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0378-4274(99)00230-1","article-title":"Glutathione S-transferase: genetics and role in toxicology","volume":"112-113","author":"Strange","year":"2000","journal-title":"Toxicol Lett"},{"key":"10.1111\/jcpt.12105-BIB0013|jcpt12105-cit-0013","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/BF01086149","article-title":"Pharmacokinetics of isoniazid metabolism in man","volume":"4","author":"Ellard","year":"1976","journal-title":"J Pharmacokinet Biopharm"},{"key":"10.1111\/jcpt.12105-BIB0014|jcpt12105-cit-0014","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0300-483X(84)90063-5","article-title":"Acetylhydrazine hepatotoxicity: the role of covalent binding","volume":"30","author":"Woodward","year":"1984","journal-title":"Toxicology"},{"key":"10.1111\/jcpt.12105-BIB0015|jcpt12105-cit-0015","first-page":"1499","article-title":"The influence of risk factors on the severity of anti-tuberculosis drug-induced hepatotoxicity","volume":"8","author":"Fern\u00e1ndez-Villar","year":"2004","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1111\/jcpt.12105-BIB0016|jcpt12105-cit-0016","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/j.1440-1746.2010.06355.x","article-title":"Role of polymorphic N-acetyltransferase 2 and cytochrome P4502E1 gene in antituberculosis treatment-induced hepatitis","volume":"26","author":"Bose","year":"2011","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1111\/jcpt.12105-BIB0017|jcpt12105-cit-0017","first-page":"622","article-title":"NAT2 and CYP2E1 polymorphisms and susceptibility to first-line anti-tuberculosis drug-induced hepatitis","volume":"14","author":"Lee","year":"2010","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1111\/jcpt.12105-BIB0018|jcpt12105-cit-0018","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1177\/147323001003800324","article-title":"Genetic polymorphisms of cytochrome P450 and glutathione S-transferase associated with antituberculosis drug-induced hepatotoxicity in Chinese tuberculosis patients","volume":"38","author":"Wang","year":"2010","journal-title":"J Int Med Res"},{"key":"10.1111\/jcpt.12105-BIB0019|jcpt12105-cit-0019","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev.pharmtox.45.120403.095857","article-title":"Glutathione transferases","volume":"45","author":"Hayes","year":"2005","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1111\/jcpt.12105-BIB0020|jcpt12105-cit-0020","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1016\/j.fct.2007.06.001","article-title":"Zingiber officinale Roscoe prevents acetaminophen-induced acute hepatotoxicity by enhancing hepatic antioxidant status","volume":"45","author":"Ajith","year":"2007","journal-title":"Food Chem Toxicol"},{"key":"10.1111\/jcpt.12105-BIB0021|jcpt12105-cit-0021","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.jep.2007.05.014","article-title":"The potent protective effect of wild ginseng (Panax ginseng C.A. Meyer) against benzo [alpha] pyrene-induced toxicity through metabolic regulation of CYP1A1 and GSTs","volume":"112","author":"Gum","year":"2007","journal-title":"J Ethnopharmacol"},{"key":"10.1111\/jcpt.12105-BIB0022|jcpt12105-cit-0022","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.coph.2007.06.009","article-title":"Genetic polymorphism and function of glutathione S-transferases in tumor drug resistance","volume":"7","author":"Lo","year":"2007","journal-title":"Curr Opin Pharmacol"},{"key":"10.1111\/jcpt.12105-BIB0023|jcpt12105-cit-0023","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/00004836-199604000-00012","article-title":"Hepatotoxicity due to antituberculosis therapy. Clinical profile and reintroduction of therapy","volume":"22","author":"Singh","year":"1996","journal-title":"J Clin Gastroenterol"},{"key":"10.1111\/jcpt.12105-BIB0024|jcpt12105-cit-0024","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0002-9343(84)90697-1","article-title":"Short-course chemotherapy for tuberculosis with mainly twice-weekly isoniazid and rifampin. Community physicians\u2019 seven-year experience with mainly outpatients","volume":"77","author":"Dutt","year":"1984","journal-title":"Am J Med"},{"key":"10.1111\/jcpt.12105-BIB0025|jcpt12105-cit-0025","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/0168-8278(90)90124-A","article-title":"Criteria of drug induced liver disorders: reform of international consensus meeting","volume":"11","author":"Benichou","year":"1990","journal-title":"J Hepatol"},{"key":"10.1111\/jcpt.12105-BIB0026|jcpt12105-cit-0026","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1590\/S0074-02762011000600011","article-title":"Genetic polymorphisms of NAT2, CYP2E1 and GST enzymes and the occurrence of antituberculosis drug-induced hepatitis in Brazilian TB patients","volume":"106","author":"Teixeira","year":"2011","journal-title":"Mem Inst Oswaldo Cruz, Rio de Janeiro"},{"key":"10.1111\/jcpt.12105-BIB0027|jcpt12105-cit-0027","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/j.1440-1681.2012.05713.x","article-title":"NAT2 and CYP2E1 polymorphisms associated with antituberculosis drug-induced hepatotoxicity in Chinese patients","volume":"39","author":"An","year":"2012","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1111\/jcpt.12105-BIB0028|jcpt12105-cit-0028","first-page":"29","article-title":"Molecular genetics and epidemiology of the NAT1 and NAT2 acetylation polymorphisms","volume":"9","author":"Hein","year":"2000","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1111\/jcpt.12105-BIB0029|jcpt12105-cit-0029","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1046\/j.1440-1746.2001.02585.x","article-title":"Increased risk of antituberculosis drug-induced hepatotoxicity in individuals with glutathione S-transferase M1 \u2018null\u2019 mutation","volume":"16","author":"Roy","year":"2001","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1111\/jcpt.12105-BIB0030|jcpt12105-cit-0030","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s12072-011-9309-4","article-title":"Comparison between acetylator phenotype and genotype polymorphism of n-acetyltransferase-2 in tuberculosis patients","volume":"6","author":"Rana","year":"2011","journal-title":"Hepatol Int"},{"key":"10.1111\/jcpt.12105-BIB0031|jcpt12105-cit-0031","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1111\/jgh.12194","article-title":"Association of NAT2 and CYP2E1 gene polymorphisms with anti-tuberculosis drug induced hepatotoxicity in Western India","volume":"28","author":"Gupta","year":"2013","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1111\/jcpt.12105-BIB0032|jcpt12105-cit-0032","doi-asserted-by":"crossref","first-page":"6003","DOI":"10.3748\/wjg.v13.45.6003","article-title":"NAT2 6A, a haplotype of the N-acetyltransferase 2 gene, is an important biomarker for risk of anti-tuberculosis drug-induced hepatotoxicity in Japanese patients with tuberculosis","volume":"13","author":"Higuchi","year":"2007","journal-title":"World J Gastroenterol"},{"key":"10.1111\/jcpt.12105-BIB0033|jcpt12105-cit-0033","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/hep.1840060223","article-title":"Elevated serum aminotransferase induced by isoniazid in relation to isoniazid acetylator phenotype","volume":"6","author":"Yamamoto","year":"1986","journal-title":"Hepatology"},{"key":"10.1111\/jcpt.12105-BIB0034|jcpt12105-cit-0034","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/cpt197518170","article-title":"Increased incidence of isoniazid hepatitis in rapid acetylators: possible relation to hydranize metabolites","volume":"18","author":"Mitchell","year":"1975","journal-title":"Clin Pharmacol Ther"},{"key":"10.1111\/jcpt.12105-BIB0035|jcpt12105-cit-0035","first-page":"15","volume-title":"Drug-induced liver disease","author":"Watking","year":"2003"},{"key":"10.1111\/jcpt.12105-BIB0036|jcpt12105-cit-0036","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2486\/indhealth.38.143","article-title":"Polymorphism of drug-metabolizing enzymes in relation to individual susceptibility to industrial chemicals","volume":"38","author":"Nakajima","year":"2000","journal-title":"Ind Health"},{"key":"10.1111\/jcpt.12105-BIB0037|jcpt12105-cit-0037","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.tube.2007.05.012","article-title":"Genetic polymorphisms of NAT2 and CYP2E1 associated with anti-tuberculosis drug-induced hepatotoxicity in Korean patients with pulmonary tuberculosis","volume":"87","author":"Cho","year":"2007","journal-title":"Tuberculosis"},{"key":"10.1111\/jcpt.12105-BIB0038|jcpt12105-cit-0038","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/j.1365-2710.2012.01334.x","article-title":"CYP2E1, GSTM1 and GSTT1 genetic polymorphisms and susceptibility to anti-tuberculosis drug-induced hepatotoxicity: a nested case-control study","volume":"37","author":"Tang","year":"2012","journal-title":"J Clin Pharm Ther"},{"key":"10.1111\/jcpt.12105-BIB0039|jcpt12105-cit-0039","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/(SICI)1522-7146(1996)11:3<139::AID-JBT6>3.0.CO;2-L","article-title":"Study of oxidative stress in isoniazid-induced hepatic injury in young rats with and without protein-energy malnutrition","volume":"11","author":"Sodhi","year":"1996","journal-title":"J Biochem Toxicol"},{"key":"10.1111\/jcpt.12105-BIB0040|jcpt12105-cit-0040","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jhep.2007.02.009","article-title":"Genetic polymorphisms of manganese superoxide dismutase, NAD(P)H: quinone oxidoreductase, glutathione S-transferase M1 and T1, and susceptibility to drug-induced liver injury","volume":"47","author":"Huang","year":"2007","journal-title":"J Hepatol"},{"key":"10.1111\/jcpt.12105-BIB0041|jcpt12105-cit-0041","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1365-2710.2009.01101.x","article-title":"GSTT1 and GSTM1 gene deletions are not associated with hepatotoxicity caused by antitubercular drugs","volume":"35","author":"Chatterjee","year":"2010","journal-title":"J Clin Pharm Ther"},{"key":"10.1111\/jcpt.12105-BIB0042|jcpt12105-cit-0042","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1111\/j.1478-3231.2008.01700.x","article-title":"Influence of glutathione S-transferase M1 and T1 homozygous null mutations on the risk of antituberculosis drug-induced hepatotoxicity in Caucasian population","volume":"28","author":"Leiro","year":"2008","journal-title":"Liver Int"},{"key":"10.1111\/jcpt.12105-BIB0043|jcpt12105-cit-0043","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/BF03262213","article-title":"Genetic interaction between NAT2, GSTM1, GSTT1, CYP2E1, and environmental factors is associated with adverse reactions to anti-tuberculosis drugs","volume":"16","author":"Costa","year":"2012","journal-title":"Mol Diagn Ther"},{"key":"10.1111\/jcpt.12105-BIB0044|jcpt12105-cit-0044","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2131\/jts.33.187","article-title":"Effects of N-acetyltransferase 2 (NAT2), CYP2E1 and Glutathione S-transferase (GST) genotypes on the serum concentrations of isoniazid and metabolites in tuberculosis patients","volume":"33","author":"Fukino","year":"2008","journal-title":"J Toxicol Sci"}],"container-title":["Journal of Clinical Pharmacy and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpt.12105","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpt.12105","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/jcpt.12105\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T18:05:10Z","timestamp":1671818710000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpt.12105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,5]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,2]]}},"URL":"https:\/\/doi.org\/10.1111\/jcpt.12105","archive":["Portico"],"relation":{},"ISSN":["0269-4727"],"issn-type":[{"value":"0269-4727","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11,5]]}}}