{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:13:28Z","timestamp":1791976408212,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T00:00:00Z","timestamp":1468540800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T00:00:00Z","timestamp":1468540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001003","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001003","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pharm Ther"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1111\/jcpt.12422","type":"journal-article","created":{"date-parts":[[2016,7,16]],"date-time":"2016-07-16T04:52:47Z","timestamp":1468644767000},"page":"459-477","source":"Crossref","is-referenced-by-count":116,"title":["Safety of metamizole: a systematic review of the literature"],"prefix":"10.1155","volume":"41","author":[{"given":"S.","family":"Andrade","sequence":"first","affiliation":[{"name":"Meyers Primary Care Institute and University of Massachusetts Medical School; Worcester MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. B.","family":"Bartels","sequence":"additional","affiliation":[{"name":"Corporate Department Global Epidemiology; Boehringer Ingelheim GmbH; Ingelheim am Rhein Germany"},{"name":"Institute of Epidemiology; Social Medicine and Health Systems Research; Hannover Medical School; Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Lange","sequence":"additional","affiliation":[{"name":"Consumer Health Care Development, Medicine, and Regulatory Affairs; Boehringer Ingelheim GmbH; Ingelheim am Rhein Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Sandford","sequence":"additional","affiliation":[{"name":"Meyers Primary Care Institute and University of Massachusetts Medical School; Worcester MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Gurwitz","sequence":"additional","affiliation":[{"name":"Meyers Primary Care Institute and University of Massachusetts Medical School; Worcester MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,15]]},"reference":[{"key":"10.1111\/jcpt.12422-BIB0001|jcpt12422-cit-0001","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1007\/BF03261998","article-title":"Balancing the risks and benefits of the use of over-the-counter pain medications in children","volume":"35","author":"Barzaga","year":"2012","journal-title":"Drug Saf"},{"key":"10.1111\/jcpt.12422-BIB0002|jcpt12422-cit-0002","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.bpa.2006.12.002","article-title":"Update on the role of non-opioids for postoperative pain treatment","volume":"21","author":"Schug","year":"2007","journal-title":"Best Pract Res Clin Anaesthesiol"},{"key":"10.1111\/jcpt.12422-BIB0003|jcpt12422-cit-0003","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/BF00278592","article-title":"Metamizole: reassessment of its therapeutic role","volume":"38","author":"Arellano","year":"1990","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1111\/jcpt.12422-BIB0004|jcpt12422-cit-0004","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1016\/S0895-4356(98)00076-6","article-title":"Comparative safety evaluation of non-narcotic analgesics","volume":"51","author":"Andrade","year":"1998","journal-title":"J Clin Epidemiol"},{"key":"10.1111\/jcpt.12422-BIB0005|jcpt12422-cit-0005","doi-asserted-by":"crossref","first-page":"e0122918","DOI":"10.1371\/journal.pone.0122918","article-title":"Metamizole-associated adverse events: a systematic review and meta-analysis","volume":"10","author":"K\u00f6tter","year":"2015","journal-title":"PLoS ONE"},{"issue":"Suppl 4","key":"10.1111\/jcpt.12422-BIB0006|jcpt12422-cit-0006","doi-asserted-by":"crossref","first-page":"60","DOI":"10.2165\/00003495-198600324-00006","article-title":"Pyrazolone derivatives","volume":"32","author":"Brogden","year":"1986","journal-title":"Drugs"},{"key":"10.1111\/jcpt.12422-BIB0007|jcpt12422-cit-0007","first-page":"440","article-title":"Metamizol-a new effective analgesic with a long history. Overview of its pharmacology and clinical use","volume":"139","author":"Fendrich","year":"2000","journal-title":"Casopis Lekaru Ceskych"},{"key":"10.1111\/jcpt.12422-BIB0008|jcpt12422-cit-0008","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1590\/S1516-31802005000500009","article-title":"Neutropenia, agranulocytosis and dipyrone","volume":"123","author":"Hamerschlak","year":"2005","journal-title":"Sao Paulo Med J"},{"key":"10.1111\/jcpt.12422-BIB0009|jcpt12422-cit-0009","doi-asserted-by":"crossref","first-page":"544","DOI":"10.3109\/0886022X.2011.569107","article-title":"Acute kidney injury associated with metamizole sodium ingestion","volume":"33","author":"Hassan","year":"2011","journal-title":"Ren Fail"},{"key":"10.1111\/jcpt.12422-BIB0010|jcpt12422-cit-0010","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2478\/pjvs-2014-0030","article-title":"Pharmacological characteristics of metamizole","volume":"17","author":"Jasiecka","year":"2014","journal-title":"Pol J Vet Sci"},{"key":"10.1111\/jcpt.12422-BIB0011|jcpt12422-cit-0011","first-page":"A4323","article-title":"Metamizole in postoperative pain management","volume":"156","author":"Koster","year":"2012","journal-title":"Ned Tijdschr Geneeskd"},{"key":"10.1111\/jcpt.12422-BIB0012|jcpt12422-cit-0012","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2165\/00002018-200730010-00006","article-title":"A population-based case-control teratologic study of oral dipyrone treatment during pregnancy","volume":"30","author":"Banhidy","year":"2007","journal-title":"Drug Saf"},{"key":"10.1111\/jcpt.12422-BIB0013|jcpt12422-cit-0013","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s00228-012-1386-3","article-title":"Upper gastrointestinal bleeding associated with NSAIDs, other drugs and interactions: a nested case-control study in a new general practice database","volume":"69","author":"Abajo","year":"2013","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1111\/jcpt.12422-BIB0014|jcpt12422-cit-0014","first-page":"593","article-title":"Effectiveness of early dipyrone administration on severity of dengue virus infection in a prospective cohort","volume":"23","author":"Diaz-Quijano","year":"2005","journal-title":"Enferm Infecc Microbiol Clin"},{"key":"10.1111\/jcpt.12422-BIB0015|jcpt12422-cit-0015","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00228-013-1618-1","article-title":"Drug-induced agranulocytosis in the Berlin case-control surveillance study","volume":"70","author":"Huber","year":"2014","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1111\/jcpt.12422-BIB0016|jcpt12422-cit-0016","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1001\/archinte.165.8.869","article-title":"Population-based drug-induced agranulocytosis","volume":"165","author":"Ibanez","year":"2005","journal-title":"Arch Intern Med"},{"key":"10.1111\/jcpt.12422-BIB0017|jcpt12422-cit-0017","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/pds.822","article-title":"Risk of anaphylaxis in a hospital population in relation to the use of various drugs: an international study","volume":"12","author":"International Collaborative Study of Severe Anaphylaxis","year":"2003","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1111\/jcpt.12422-BIB0018|jcpt12422-cit-0018","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0140-6736(91)90744-A","article-title":"Upper gastrointestinal bleeding in relation to previous use of analgesics and non-steroidal anti-inflammatory drugs. Catalan Countries Study on Upper Gastrointestinal Bleeding","volume":"337","author":"Laporte","year":"1991","journal-title":"Lancet"},{"key":"10.1111\/jcpt.12422-BIB0019|jcpt12422-cit-0019","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1111\/j.1365-2036.2007.03338.x","article-title":"Risk of acute liver injury associated with the use of drugs: a multicentre population survey","volume":"25","author":"Sabate","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1111\/jcpt.12422-BIB0020|jcpt12422-cit-0020","doi-asserted-by":"crossref","first-page":"573","DOI":"10.4269\/ajtmh.1999.60.573","article-title":"Agranulocytosis in Bangkok, Thailand: a predominantly drug-induced disease with an unusually low incidence. Aplastic Anemia Study Group","volume":"60","author":"Shapiro","year":"1999","journal-title":"Am J Trop Med Hyg"},{"key":"10.1111\/jcpt.12422-BIB0021|jcpt12422-cit-0021","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1097\/00001648-199609000-00015","article-title":"Use of dipyrone during pregnancy and risk of Wilms' tumor. Brazilian Wilms' Tumor Study Group","volume":"7","author":"Sharpe","year":"1996","journal-title":"Epidemiology"},{"key":"10.1111\/jcpt.12422-BIB0022|jcpt12422-cit-0022","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1159\/000071293","article-title":"Bleeding complications after percutaneous liver biopsy. An analysis of risk factors","volume":"67","author":"Terjung","year":"2003","journal-title":"Digestion"},{"key":"10.1111\/jcpt.12422-BIB0023|jcpt12422-cit-0023","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1001\/archinte.159.4.369","article-title":"A population-based case-cohort study of drug-associated agranulocytosis","volume":"159","author":"Klauw","year":"1999","journal-title":"Arch Intern Med"},{"key":"10.1111\/jcpt.12422-BIB0024|jcpt12422-cit-0024","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/00042737-200302000-00011","article-title":"Risk of upper gastrointestinal bleeding associated with non-aspirin cardiovascular drugs, analgesics and nonsteroidal anti-inflammatory drugs","volume":"15","author":"Lanas","year":"2003","journal-title":"Eur J Gastro Hepatol"},{"key":"10.1111\/jcpt.12422-BIB0025|jcpt12422-cit-0025","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1097\/CEJ.0000000000000070","article-title":"Pregnancy, maternal exposure to analgesic medicines, and leukemia in Brazilian children below 2 years of age","volume":"24","author":"Couto","year":"2015","journal-title":"Eur J Cancer Prev"},{"key":"10.1111\/jcpt.12422-BIB0026|jcpt12422-cit-0026","first-page":"2542","article-title":"Transplacental chemical exposure and risk of infant leukemia with MLL gene fusion","volume":"61","author":"Alexander","year":"2001","journal-title":"Cancer Res"},{"key":"10.1111\/jcpt.12422-BIB0027|jcpt12422-cit-0027","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.ejogrb.2004.07.004","article-title":"Metamizol (dipyrone, optalgin) in pregnancy, is it safe? A prospective comparative study","volume":"119","author":"Bar-Oz","year":"2005","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1111\/jcpt.12422-BIB0028|jcpt12422-cit-0028","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s00228-008-0513-7","article-title":"Incidence and risk factors for agranulocytosis in Latin American countries-the Latin Study: a multicenter study","volume":"64","author":"Hamerschlak","year":"2008","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1111\/jcpt.12422-BIB0029|jcpt12422-cit-0029","doi-asserted-by":"crossref","first-page":"411","DOI":"10.2165\/00002018-200427060-00005","article-title":"Upper gastrointestinal bleeding associated with the use of NSAIDs: newer versus older agents","volume":"27","author":"Laporte","year":"2004","journal-title":"Drug Saf"},{"key":"10.1111\/jcpt.12422-BIB0030|jcpt12422-cit-0030","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1136\/gut.2005.080754","article-title":"Risk of upper gastrointestinal ulcer bleeding associated with selective cyclo-oxygenase-2 inhibitors, traditional non-aspirin non-steroidal anti-inflammatory drugs, aspirin and combinations","volume":"55","author":"Lanas","year":"2006","journal-title":"Gut"},{"key":"10.1111\/jcpt.12422-BIB0031|jcpt12422-cit-0031","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.3324\/haematol.2008.002642","article-title":"Incidence and risk factors of aplastic anemia in Latin American countries: the LATIN case-control study","volume":"94","author":"Maluf","year":"2009","journal-title":"Haematologica"},{"key":"10.1111\/jcpt.12422-BIB0032|jcpt12422-cit-0032","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1600-0609.1996.tb01643.x","article-title":"Drug use and aplastic anaemia: the French experience. French Cooperative Group for the Epidemiological Study of Aplastic Anaemia","volume":"60","author":"Mary","year":"1996","journal-title":"Eur J Haematol Suppl"},{"key":"10.1111\/jcpt.12422-BIB0033|jcpt12422-cit-0033","volume-title":"The drug etiology of agranulocytosis and aplastic anemia","author":"Kaufman","year":"1991"},{"key":"10.1111\/jcpt.12422-BIB0034|jcpt12422-cit-0034","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s00228-004-0836-y","article-title":"Agranulocytosis associated with dipyrone","volume":"60","author":"Ibanez","year":"2005","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1111\/jcpt.12422-BIB0035|jcpt12422-cit-0035","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s00228-014-1777-8","article-title":"Metamizole-induced agranulocytosis revisited: results from the prospective Berlin Case-Control Surveillance Study","volume":"71","author":"Huber","year":"2015","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1111\/jcpt.12422-BIB0036|jcpt12422-cit-0036","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s00228-002-0465-2","article-title":"Agranulocytosis and other blood dyscrasias associated with dipyrone (metamizole)","volume":"58","author":"Hedenmalm","year":"2002","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1111\/jcpt.12422-BIB0037|jcpt12422-cit-0037","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/pds.697","article-title":"Utilization pattern of metamizole in northern Sweden and risk estimates of agranulocytosis","volume":"11","author":"Backstrom","year":"2002","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1111\/jcpt.12422-BIB0038|jcpt12422-cit-0038","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1177\/147323001003800419","article-title":"Update on the incidence of metamizole sodium-induced blood dyscrasias in Poland","volume":"38","author":"Basak","year":"2010","journal-title":"J Int Med Res"},{"key":"10.1111\/jcpt.12422-BIB0039|jcpt12422-cit-0039","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1177\/147323000203000504","article-title":"The incidence of metamizole sodium-induced agranulocytosis in Poland","volume":"30","author":"Maj","year":"2002","journal-title":"J Int Med Res"},{"key":"10.1111\/jcpt.12422-BIB0040|jcpt12422-cit-0040","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s00228-014-1781-z","article-title":"Hematological safety of metamizole: retrospective analysis of WHO and Swiss spontaneous safety reports","volume":"71","author":"Blaser","year":"2015","journal-title":"Eur J Clin Pharmacol"}],"container-title":["Journal of Clinical Pharmacy and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpt.12422","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpt.12422","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/jcpt.12422\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T07:48:25Z","timestamp":1718696905000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpt.12422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,15]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,10]]}},"URL":"https:\/\/doi.org\/10.1111\/jcpt.12422","archive":["Portico"],"relation":{},"ISSN":["0269-4727"],"issn-type":[{"value":"0269-4727","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7,15]]}}}