{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:49:17Z","timestamp":1792608557165,"version":"4.5.0"},"reference-count":25,"publisher":"Hindawi Limited","issue":"3","license":[{"start":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T00:00:00Z","timestamp":1511827200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T00:00:00Z","timestamp":1511827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pharm Ther"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1111\/jcpt.12657","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T17:23:09Z","timestamp":1511976189000},"page":"348-352","source":"Crossref","is-referenced-by-count":29,"title":["Dexmedetomidine as an adjuvant to 0.5% ropivacaine in ultrasound-guided axillary brachial plexus block"],"prefix":"10.1155","volume":"43","author":[{"given":"E.","family":"Koraki","sequence":"first","affiliation":[{"name":"Department of Anesthesiology; General Hospital of Thessaloniki \u201cG. Papanikolaou\u201d; Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Stachtari","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology; General Hospital of Thessaloniki \u201cG. Papanikolaou\u201d; Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Kapsokalyvas","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology; General Hospital of Thessaloniki \u201cG. Papanikolaou\u201d; Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Stergiouda","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology; General Hospital of Thessaloniki \u201cG. Papanikolaou\u201d; Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Katsanevaki","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology; General Hospital of Thessaloniki \u201cG. Papanikolaou\u201d; Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Trikoupi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology; General Hospital of Thessaloniki \u201cG. Papanikolaou\u201d; Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","published-online":{"date-parts":[[2017,11,28]]},"reference":[{"key":"10.1111\/jcpt.12657-BIB0001|jcpt12657-cit-0001","first-page":"246","article-title":"Ultrasound guided axillary brachial plexus block","volume":"16","author":"Ranganath","year":"2014","journal-title":"Med Ultrason"},{"key":"10.1111\/jcpt.12657-BIB0002|jcpt12657-cit-0002","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.7292.1","article-title":"Upper extremity nerve block: how can benefit, duration, and safety be improved? An update","volume":"5","author":"Brattwall","year":"2016","journal-title":"F1000Res"},{"key":"10.1111\/jcpt.12657-BIB0003|jcpt12657-cit-0003","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1213\/ANE.0b013e3182285e01","article-title":"Continuous peripheral nerve blocks: a review of the published evidence","volume":"113","author":"Ilfeld","year":"2011","journal-title":"Anesth Analg"},{"key":"10.1111\/jcpt.12657-BIB0004|jcpt12657-cit-0004","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1365-2044.2009.06201.x","article-title":"Local anaesthetics and adjuvants - future developments","volume":"65","author":"Wiles","year":"2010","journal-title":"Anaesthesia"},{"key":"10.1111\/jcpt.12657-BIB0005|jcpt12657-cit-0005","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0014-2999(88)90744-3","article-title":"Characterization of the selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist","volume":"150","author":"Virtanen","year":"1988","journal-title":"Eur J Pharmacol"},{"key":"10.1111\/jcpt.12657-BIB0006|jcpt12657-cit-0006","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1097\/AAP.0b013e3181ef4cf0","article-title":"Perineural dexmedetomidine provides an increased duration of analgesia to a thermal stimulus when compared with a systemic control in a rat sciatic nerve block","volume":"35","author":"Brummett","year":"2010","journal-title":"Reg Anesth Pain Med"},{"key":"10.1111\/jcpt.12657-BIB0007|jcpt12657-cit-0007","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.curtheres.2013.03.001","article-title":"Effects of perineural administration of dexmedetomidine in combination with levobupivacaine in a rat sciatic nerve block","volume":"74","author":"Ali","year":"2013","journal-title":"Curr Ther Res Clin Exp"},{"key":"10.1111\/jcpt.12657-BIB0008|jcpt12657-cit-0008","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1097\/EJA.0b013e3283347c15","article-title":"Addition of dexmedetomidine to bupivacaine for greater palatine nerve block prolongs postoperative analgesia after cleft palate repair","volume":"27","author":"Obayah","year":"2010","journal-title":"Eur J Anaesthesiol"},{"key":"10.1111\/jcpt.12657-BIB0009|jcpt12657-cit-0009","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1093\/bja\/aes400","article-title":"Dexmedetomidine as an adjuvant to ropivacaine prolongs peripheral nerve block: a volunteer study","volume":"110","author":"Marhofer","year":"2013","journal-title":"Br J Anaesth"},{"key":"10.1111\/jcpt.12657-BIB0010|jcpt12657-cit-0010","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1093\/bja\/aew411","article-title":"Evidence basis for using perineural dexmedetomidine to enhance the quality of brachial plexus nerve blocks: a systematic review and meta-analysis of randomized controlled trials","volume":"118","author":"Vorobeichik","year":"2017","journal-title":"Br J Anaesth"},{"key":"10.1111\/jcpt.12657-BIB0011|jcpt12657-cit-0011","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1017\/S0265021507003079","article-title":"The efficacy and neurotoxicity of dexmedetomidine administered via the epidural route","volume":"25","author":"Konakci","year":"2008","journal-title":"Eur J Anaesthesiol"},{"key":"10.1111\/jcpt.12657-BIB0012|jcpt12657-cit-0012","first-page":"6","article-title":"Effect of dexmedetomidine as an adjuvant to 0.75% ropivacaine in axillary brachial plexus block for forearm and hand surgeries","volume":"7","author":"Sundaram","year":"2016","journal-title":"Int J Biomed Res"},{"key":"10.1111\/jcpt.12657-BIB0013|jcpt12657-cit-0013","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3410\/M2-90","article-title":"Use of dexmedetomidine for pain control","volume":"2","author":"Grosu","year":"2010","journal-title":"F1000 Med Rep"},{"key":"10.1111\/jcpt.12657-BIB0014|jcpt12657-cit-0014","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1093\/bja\/aep107","article-title":"Dexmedetomidine, an alpha2-adrenergic agonist, inhibits neuronal delayed-rectifier potassium current and sodium current","volume":"103","author":"Chen","year":"2009","journal-title":"Br J Anaesth"},{"key":"10.1111\/jcpt.12657-BIB0015|jcpt12657-cit-0015","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1097\/ALN.0000000000000983","article-title":"IV and perineural dexmedetomidine similarly prolong the duration of analgesia after interscalene brachial plexus block: a randomized, three-arm, triple-masked, placebo-controlled trial","volume":"124","author":"Abdallah","year":"2016","journal-title":"Anesthesiology"},{"key":"10.1111\/jcpt.12657-BIB0016|jcpt12657-cit-0016","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1097\/AAP.0000000000000033","article-title":"Dexmedetomidine added to ropivacaine extends the duration of interscalene brachial plexus blocks for elective shoulder surgery when compared with ropivacaine alone: a single-center, prospective, triple-blind, randomized controlled trial","volume":"39","author":"Fritsch","year":"2014","journal-title":"Reg Anesth Pain Med"},{"key":"10.1111\/jcpt.12657-BIB0017|jcpt12657-cit-0017","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1213\/ANE.0000000000002014","article-title":"Perineural dexmedetomidine is more effective than clonidine when added to local anesthetic for supraclavicular brachial plexus block: a systematic review and meta-analysis","volume":"124","author":"El-Boghdadly","year":"2017","journal-title":"Anesth Analg"},{"key":"10.1111\/jcpt.12657-BIB0018|jcpt12657-cit-0018","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.redar.2015.04.012","article-title":"Supraclavicular brachial plexus block using ropivacaine alone or combined with dexmedetomidine for upper limb surgery: a prospective, randomized, double-blinded, comparative study","volume":"63","author":"Das","year":"2016","journal-title":"Rev Esp Anestesiol Reanim"},{"key":"10.1111\/jcpt.12657-BIB0019|jcpt12657-cit-0019","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1213\/ANE.0000000000001006","article-title":"The analgesic efficacy of dexmedetomidine as an adjunct to local anesthetics in supraclavicular brachial plexus block: a randomized controlled trial","volume":"121","author":"Bharti","year":"2015","journal-title":"Anesth Analg"},{"key":"10.1111\/jcpt.12657-BIB0020|jcpt12657-cit-0020","doi-asserted-by":"crossref","first-page":"283","DOI":"10.4097\/kjae.2014.66.4.283","article-title":"Comparison of dexmedetomidine and epinephrine as an adjuvant to 1% mepivacaine in brachial plexus block","volume":"66","author":"Song","year":"2014","journal-title":"Korean J Anesthesiol"},{"key":"10.1111\/jcpt.12657-BIB0021|jcpt12657-cit-0021","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3344\/kjp.2016.29.1.29","article-title":"Dexamethasone or dexmedetomidine as local anesthetic adjuvants for ultrasound-guided axillary brachial plexus blocks with nerve stimulation","volume":"29","author":"Lee","year":"2016","journal-title":"Korean J Pain"},{"key":"10.1111\/jcpt.12657-BIB0022|jcpt12657-cit-0022","doi-asserted-by":"crossref","first-page":"38","DOI":"10.4103\/1658-354X.169473","article-title":"Comparison of effects of ropivacaine with and without dexmedetomidine in axillary brachial plexus block: a prospective randomized double-blinded clinical trial","volume":"10","author":"Bangera","year":"2016","journal-title":"Saudi J Anaesth"},{"key":"10.1111\/jcpt.12657-BIB0023|jcpt12657-cit-0023","first-page":"680","article-title":"Perineural administration of dexmedetomidine in combination with ropivacaine prolongs axillary brachial plexus block","volume":"7","author":"Zhang","year":"2014","journal-title":"Int J Clin Exp Med"},{"key":"10.1111\/jcpt.12657-BIB0024|jcpt12657-cit-0024","doi-asserted-by":"crossref","first-page":"4049","DOI":"10.3390\/ijms15034049","article-title":"Perineural dexmedetomidine attenuates inflammation in rat sciatic nerve via the NF-\u03baB pathway","volume":"15","author":"Huang","year":"2014","journal-title":"Int J Mol Sci"},{"key":"10.1111\/jcpt.12657-BIB0025|jcpt12657-cit-0025","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1097\/ALN.0b013e3181bbcd2c","article-title":"\u201cAbove All, Do No Harm\u201d Hippocrates","volume":"111","author":"Gerner","year":"2009","journal-title":"Anesthesiology"}],"container-title":["Journal of Clinical Pharmacy and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpt.12657","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/jcpt.12657\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T18:03:26Z","timestamp":1671818606000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpt.12657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,28]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,6]]}},"URL":"https:\/\/doi.org\/10.1111\/jcpt.12657","archive":["Portico"],"relation":{},"ISSN":["0269-4727"],"issn-type":[{"value":"0269-4727","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11,28]]}}}