{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T09:24:38Z","timestamp":1789550678350,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,3]],"date-time":"2018-03-03T00:00:00Z","timestamp":1520035200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2018,3,3]],"date-time":"2018-03-03T00:00:00Z","timestamp":1520035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Beijing Municipal Administration of Hospitals\u2019 Youth Programme","award":["QML20160703"],"award-info":[{"award-number":["QML20160703"]}]},{"name":"Beijing Key Laboratory of Bio-characteristic Profiling for Evaluation of Rational Drug Use","award":["BZ0439"],"award-info":[{"award-number":["BZ0439"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81503135"],"award-info":[{"award-number":["81503135"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pharm Ther"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1111\/jcpt.12678","type":"journal-article","created":{"date-parts":[[2018,3,3]],"date-time":"2018-03-03T18:32:38Z","timestamp":1520101958000},"page":"507-512","source":"Crossref","is-referenced-by-count":5,"title":["Genotype and allele frequencies of <i>TYMS<\/i>\n rs2790 A &gt; G polymorphism in a Chinese paediatric population with acute lymphoblastic leukaemia"],"prefix":"10.1155","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9121-8168","authenticated-orcid":false,"given":"S.-M.","family":"Wang","sequence":"first","affiliation":[{"name":"Beijing Key Laboratory of Bio-characteristic Profiling for Evaluation of Rational Drug Use; Beijing Shijitan Hospital; Capital Medical University; Beijing China"},{"name":"Department of Pharmacy; Beijing Shijitan Hospital; Capital Medical University; Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.-X.","family":"Zeng","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Bio-characteristic Profiling for Evaluation of Rational Drug Use; Beijing Shijitan Hospital; Capital Medical University; Beijing China"},{"name":"Department of Pharmacy; Beijing Shijitan Hospital; Capital Medical University; Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.-S.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics; Beijing Shijitan Hospital; Capital Medical University; Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.-L.","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pharmacy; Beijing Shijitan Hospital; Capital Medical University; Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Yan","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Bio-characteristic Profiling for Evaluation of Rational Drug Use; Beijing Shijitan Hospital; Capital Medical University; Beijing China"},{"name":"Department of Pharmacy; Beijing Shijitan Hospital; Capital Medical University; Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,3]]},"reference":[{"key":"10.1111\/jcpt.12678-BIB0001|jcpt12678-cit-0001","first-page":"2538","article-title":"Comparison of thymidylate synthase (TS) protein up-regulation after exposure to TS inhibitors in normal and tumor cell lines and tissues","volume":"6","author":"Welsh","year":"2000","journal-title":"Clin Cancer Res"},{"key":"10.1111\/jcpt.12678-BIB0002|jcpt12678-cit-0002","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.2217\/pgs.13.118","article-title":"Current approaches for TYMS polymorphisms and their importance in molecular epidemiology and pharmacogenetics","volume":"14","author":"Lima","year":"2013","journal-title":"Pharmacogenomics"},{"key":"10.1111\/jcpt.12678-BIB0003|jcpt12678-cit-0003","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1038\/sj.leu.2401943","article-title":"mRNA expression levels of methotrexate resistance-related proteins in childhood leukemia as determined by a standardized competitive template-based RT-PCR method","volume":"14","author":"Rots","year":"2000","journal-title":"Leukemia"},{"key":"10.1111\/jcpt.12678-BIB0004|jcpt12678-cit-0004","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0140-6736(02)08065-0","article-title":"Polymorphism of the thymidylate synthase gene and outcome of acute lymphoblastic leukaemia","volume":"359","author":"Krajinovic","year":"2002","journal-title":"Lancet"},{"key":"10.1111\/jcpt.12678-BIB0005|jcpt12678-cit-0005","first-page":"593","article-title":"Polymorphisms in the thymidylate synthase and methylenetetrahydrofolate reductase genes and sensitivity to the low-dose methotrexate therapy in patients with rheumatoid arthritis","volume":"11","author":"Kumagai","year":"2003","journal-title":"Int J Mol Med"},{"key":"10.1111\/jcpt.12678-BIB0006|jcpt12678-cit-0006","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s10637-005-4021-7","article-title":"Thymidylate synthase pharmacogenetics","volume":"23","author":"Marsh","year":"2005","journal-title":"Invest New Drugs"},{"key":"10.1111\/jcpt.12678-BIB0007|jcpt12678-cit-0007","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1247\/csf.20.191","article-title":"Functional analysis and DNA polymorphism of the tandemly repeated sequences in the 5\u2032-terminal regulatory region of the human gene for thymidylate synthase","volume":"20","author":"Horie","year":"1995","journal-title":"Cell Struct Funct"},{"key":"10.1111\/jcpt.12678-BIB0008|jcpt12678-cit-0008","first-page":"3249","article-title":"Polymorphic tandem repeats in the thymidylate synthase gene is associated with its protein expression in human gastrointestinal cancers","volume":"19","author":"Kawakami","year":"1999","journal-title":"Anticancer Res"},{"key":"10.1111\/jcpt.12678-BIB0009|jcpt12678-cit-0009","first-page":"2898","article-title":"A novel single nucleotide polymorphism within the 5\u2032 tandem repeat polymorphism of the thymidylate synthase gene abolishes USF-1 binding and alters transcriptional activity","volume":"63","author":"Mandola","year":"2003","journal-title":"Cancer Res"},{"key":"10.1111\/jcpt.12678-BIB0010|jcpt12678-cit-0010","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/00008571-200405000-00007","article-title":"A 6\u00a0bp polymorphism in the thymidylate synthase gene causes message instability and is associated with decreased intratumoral TS mRNA levels","volume":"14","author":"Mandola","year":"2004","journal-title":"Pharmacogenetics"},{"key":"10.1111\/jcpt.12678-BIB0011|jcpt12678-cit-0011","doi-asserted-by":"crossref","first-page":"23456","DOI":"10.1074\/jbc.M600282200","article-title":"Differential stability of thymidylate synthase 3\u2032-untranslated region polymorphic variants regulated by AUF1","volume":"281","author":"Pullmann","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1111\/jcpt.12678-BIB0012|jcpt12678-cit-0012","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/sj.tpj.6500332","article-title":"Combining several polymorphisms of thymidylate synthase gene for pharmacogenetic analysis","volume":"5","author":"Krajinovic","year":"2005","journal-title":"Pharmacogenomics J"},{"key":"10.1111\/jcpt.12678-BIB0013|jcpt12678-cit-0013","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1002\/mc.22160","article-title":"Genetic polymorphisms in the microRNA binding-sites of the thymidylate synthase gene predict risk and survival in gastric cancer","volume":"54","author":"Shen","year":"2015","journal-title":"Mol Carcinog"},{"key":"10.1111\/jcpt.12678-BIB0014|jcpt12678-cit-0014","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.lungcan.2014.06.010","article-title":"MicroRNA-binding site SNPs in deregulated genes are associated with clinical outcome of non-small cell lung cancer","volume":"85","author":"Xu","year":"2014","journal-title":"Lung Cancer"},{"key":"10.1111\/jcpt.12678-BIB0015|jcpt12678-cit-0015","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/FTD.0b013e3182a94e65","article-title":"Genotype and allele frequencies of drug-metabolizing enzymes and drug transporter genes affecting immunosuppressants in the Spanish white population","volume":"36","author":"Bos\u00f3","year":"2014","journal-title":"Ther Drug Monit"},{"key":"10.1111\/jcpt.12678-BIB0016|jcpt12678-cit-0016","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/mc.22097","article-title":"Genetic variant rs16430 6\u00a0bp>0\u00a0bp at the microRNA-binding site in TYMS and risk of sporadic breast cancer risk in non-Hispanic white women aged \u2264 55\u00a0years","volume":"54","author":"Guan","year":"2015","journal-title":"Mol Carcinog"},{"key":"10.1111\/jcpt.12678-BIB0017|jcpt12678-cit-0017","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1002\/ijc.23318","article-title":"Folate metabolism genes, vegetable intake and renal cancer risk in central Europe","volume":"122","author":"Moore","year":"2008","journal-title":"Int J Cancer"},{"key":"10.1111\/jcpt.12678-BIB0018|jcpt12678-cit-0018","doi-asserted-by":"crossref","first-page":"3786","DOI":"10.1182\/blood.V99.10.3786","article-title":"Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia","volume":"99","author":"Skibola","year":"2002","journal-title":"Blood"},{"key":"10.1111\/jcpt.12678-BIB0019|jcpt12678-cit-0019","doi-asserted-by":"crossref","first-page":"906","DOI":"10.4238\/2012.April.10.6","article-title":"Thymidylate synthase enhancer region polymorphism not related to susceptibility to acute lymphoblastic leukemia in the Kashmir population","volume":"11","author":"Nazki","year":"2012","journal-title":"Genet Mol Res"},{"key":"10.1111\/jcpt.12678-BIB0020|jcpt12678-cit-0020","doi-asserted-by":"crossref","first-page":"3930","DOI":"10.1200\/JCO.2004.11.020","article-title":"Pharmacogenetic risk factors for osteonecrosis of the hip among children with leukemia","volume":"22","author":"Relling","year":"2004","journal-title":"J Clin Oncol"},{"key":"10.1111\/jcpt.12678-BIB0021|jcpt12678-cit-0021","doi-asserted-by":"crossref","first-page":"5145","DOI":"10.1182\/blood-2013-01-480335","article-title":"Germline genetic variations in methotrexate candidate genes are associated with pharmacokinetics, toxicity, and outcome in childhood acute lymphoblastic leukemia","volume":"121","author":"Radtke","year":"2013","journal-title":"Blood"},{"key":"10.1111\/jcpt.12678-BIB0022|jcpt12678-cit-0022","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.3109\/10428194.2011.639880","article-title":"Influence of folate pathway polymorphisms on high-dose methotrexate-related toxicity and survival in childhood acute lymphoblastic leukemia","volume":"53","author":"Er\u010dulj","year":"2012","journal-title":"Leuk Lymphoma"},{"key":"10.1111\/jcpt.12678-BIB0023|jcpt12678-cit-0023","doi-asserted-by":"crossref","first-page":"4752","DOI":"10.1182\/blood-2004-11-4544","article-title":"Pharmacogenetics of outcome in children with acute lymphoblastic leukemia","volume":"105","author":"Rocha","year":"2005","journal-title":"Blood"}],"container-title":["Journal of Clinical Pharmacy and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpt.12678","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/jcpt.12678\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T18:03:32Z","timestamp":1671818612000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpt.12678"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,3]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,8]]}},"URL":"https:\/\/doi.org\/10.1111\/jcpt.12678","archive":["Portico"],"relation":{},"ISSN":["0269-4727"],"issn-type":[{"value":"0269-4727","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3,3]]}}}