{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T10:35:58Z","timestamp":1782902158295,"version":"3.54.5"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T00:00:00Z","timestamp":1630022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T00:00:00Z","timestamp":1630022400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pharm Ther"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1111\/jcpt.13523","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T07:10:38Z","timestamp":1630048238000},"page":"1706-1713","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["High\u2010versus low\u2010dose clonidine for sedation and analgesia in critically ill adults: A retrospective cohort study"],"prefix":"10.1155","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1578-7956","authenticated-orcid":false,"given":"Elsa","family":"Purivatra","sequence":"first","affiliation":[{"name":"Windsor Regional Hospital Windsor Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Guenette","sequence":"additional","affiliation":[{"name":"Mount Sinai Hospital Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Coleman","sequence":"additional","affiliation":[{"name":"Infectious Disease Epidemiology Research Unit Mount Sinai Hospital Toronto Ontario Canada"},{"name":"Dalla Lana School of Public Health University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Cheung","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Mount Sinai Hospital Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Burry","sequence":"additional","affiliation":[{"name":"Leslie Dan Faculty of Pharmacy University of Toronto Mount Sinai Hospital Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005183422002"},{"issue":"4","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.4103\/0970-9185.74581","article-title":"Clonidine in adults as a sedative agent in the intensive care unit","volume":"26","author":"Jamadarkhana S","year":"2010","journal-title":"J of Anaesthesiol Clin Pharmacol"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199701000-00024"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e3181817add"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.304"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2016.3186"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2016.10.026"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.accpm.2015.06.012"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-5229.136071"},{"issue":"2","key":"e_1_2_11_11_1","first-page":"83","article-title":"Clonidine use in the intensive care unit of a tertiary care hospital: retrospective analysis","volume":"57","author":"Gillison M","year":"2004","journal-title":"Can J Hosp Pharm"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-017-1610-8"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199510000-00007"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1H421"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.13872"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2009.09060802"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1559"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875-9114.1981.tb03561.x"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1979.tb00897.x"}],"container-title":["Journal of Clinical Pharmacy and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpt.13523","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcpt.13523","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpt.13523","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,8]],"date-time":"2023-01-08T05:45:26Z","timestamp":1673156726000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpt.13523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,27]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1111\/jcpt.13523"],"URL":"https:\/\/doi.org\/10.1111\/jcpt.13523","archive":["Portico"],"relation":{},"ISSN":["0269-4727","1365-2710"],"issn-type":[{"value":"0269-4727","type":"print"},{"value":"1365-2710","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,27]]},"assertion":[{"value":"2021-04-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}