{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:08:56Z","timestamp":1785150536732,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,4,9]],"date-time":"2022-04-09T00:00:00Z","timestamp":1649462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,4,9]],"date-time":"2022-04-09T00:00:00Z","timestamp":1649462400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104420"],"award-info":[{"award-number":["82104420"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Pharmacy Therapeu"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1111\/jcpt.13665","type":"journal-article","created":{"date-parts":[[2022,4,9]],"date-time":"2022-04-09T08:50:05Z","timestamp":1649494205000},"page":"1112-1121","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["High\u2010Dose Clopidogrel versus Ticagrelor in CYP2C19 intermediate or poor metabolizers after percutaneous coronary intervention: A Meta\u2010Analysis of Randomized Trials"],"prefix":"10.1155","volume":"47","author":[{"given":"Xiao\u2010yan","family":"Sheng","sequence":"first","affiliation":[{"name":" <\/id> <\/idGroup> Integrated Hospital of Traditional Chinese Medicine Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3241-9661","authenticated-orcid":false,"given":"Hui\u2010jie","family":"An","sequence":"additional","affiliation":[{"name":"General Hospital of Southern Theatre Command, PLA Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010yang","family":"He","sequence":"additional","affiliation":[{"name":"Shenzhen Children\u2019s Hospital Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010feng","family":"Ye","sequence":"additional","affiliation":[{"name":"The Fifth Affiliated Hospital Sun Yat\u2010Sen University Zhuhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010lan","family":"Zhao","sequence":"additional","affiliation":[{"name":" <\/id> <\/idGroup> Integrated Hospital of Traditional Chinese Medicine Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7512-8138","authenticated-orcid":false,"given":"Sai","family":"Li","sequence":"additional","affiliation":[{"name":" <\/id> <\/idGroup> Integrated Hospital of Traditional Chinese Medicine Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182742cf6"},{"issue":"01","key":"e_1_2_10_3_1","first-page":"10","article-title":"Chinese guidelines for Cardiovascular Disease Prevention (2017)","volume":"46","author":"Task Force on Chinese Guidelines for the Prevention of Cardiovascular Diseases","year":"2018","journal-title":"Chinese J Cardiovascular Dis"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.170815"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000072771.11429.83"},{"key":"e_1_2_10_6_1","first-page":"22","volume-title":"Precision Medicine: a compendium of drug treatments","author":"Chen W","year":"2016"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2013.105"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1703"},{"key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/9780470712184.ch8","volume-title":"Assessing risk of bias in included studies. Cochrane Handbook for Systematic Reviews of Interventions","author":"Higgins J","year":"2008"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_2_10_11_1","unstructured":"LiLN.Relationship between CYP2C19 gene polymorphism and antiplatelet effect in patients with slow metabolism after PCI [D]. Xinjiang Medical University 2019. (In Chinese)"},{"key":"e_1_2_10_12_1","unstructured":"WeiJ.CYP2C19 gene detection optimizes dual antiplatelet treatment [D]. Zhengzhou University 2016. (In Chinese)"},{"key":"e_1_2_10_13_1","unstructured":"YangB.Research on anti\u2010platelet drugs in ACS patients with CYP2C19 intermediate metabolizer receiving PCI and the underlying mechanisms [D]. Qingdao University 2019. (In Chinese)"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.2143\/AC.71.3.3152091"},{"key":"e_1_2_10_15_1","unstructured":"ZhangHJ.The study of antiplatelet individualized therapy after percutaneous coronary intervention [D]. Qingdao University 2017. (In Chinese)"},{"issue":"05","key":"e_1_2_10_16_1","first-page":"309","article-title":"The role of precision medicine in antiplatelet drug selection after percutaneous coronary intervention","volume":"44","author":"Ren CH","year":"2017","journal-title":"Int J Cardiovasc Dis"},{"issue":"8","key":"e_1_2_10_17_1","first-page":"13310","article-title":"A randomized controlled trial to assess the efficacy and safety of doubling dose clopidogrel versus ticagrelor for the treatment of acute coronary syndrome in patients with CYP2C19*2 homozygotes","volume":"8","author":"Xiong R","year":"2015","journal-title":"Int J Clin Exp Med"},{"issue":"06","key":"e_1_2_10_18_1","first-page":"425","article-title":"Clinical efficacy of ticagrelor versus double maintenance dose of clopidogrel in poor\u2010metabolizing patients after percutaneous coronary intervention","volume":"17","author":"Shen WB","year":"2018","journal-title":"Chin J Mult Organ Elderly"},{"issue":"09","key":"e_1_2_10_19_1","first-page":"647","article-title":"Comparison study of the effects of ticagrelor and a double dose of clopidogrel on the incidence of cardiovascular ischemic events in patients with mutant CYP2C19 after percutaneous coronary intervention","volume":"17","author":"Lin LJ","year":"2018","journal-title":"Chin J Mult Organ Elderly"},{"issue":"20","key":"e_1_2_10_20_1","first-page":"3823","article-title":"Clinical study of ticagrelor for treatment of patients after percutaneous coronary intervention in CYP2C19 poor metabolizers","volume":"28","author":"Huang Q","year":"2017","journal-title":"Mod Diagn Treat"},{"key":"e_1_2_10_21_1","unstructured":"LiY.Study of individual antiplatelet agents after PCI for CYP2C19*2 patients with acute coronary syndrome [D]. Qingdao University 2017. (In Chinese)"},{"issue":"03","key":"e_1_2_10_22_1","first-page":"52","article-title":"Application Value of Genetic Testing of Drug \u2010 metabolizing Enzyme CYP2C19 in the Antiplatelet Therapy of Postoperative Coronary Heart Disease Patients Treated by PCI","volume":"24","author":"Gao B","year":"2016","journal-title":"Pract J Cardiac Cere Pneum and Vascu Dis"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.12659\/msm.903054"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/circ.131.suppl_2.216"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.118.311963"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.cj\u201012\u20100635"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(09)60441\u20104"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.02.029"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904327"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(10)61274\u20103"},{"issue":"03","key":"e_1_2_10_31_1","first-page":"190","article-title":"Meta analysis for the efficacy and safety of ticagrelor and clopidogrel in acute coronary syndrome based on CYP2C19 gene","volume":"41","author":"Li JQ","year":"2020","journal-title":"World Clinical Drugs"},{"issue":"04","key":"e_1_2_10_32_1","first-page":"110","article-title":"CYP2C19 genotype\u2010guided individualized clopidogrel therapies in acute coronary syndrome \/percutaneous coronary intervention: a network meta\u2010analysis","volume":"32","author":"He M","year":"2020","journal-title":"Strait Pharmaceutical J"}],"container-title":["Journal of Clinical Pharmacy and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpt.13665","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcpt.13665","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpt.13665","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T18:05:40Z","timestamp":1671818740000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpt.13665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,9]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1111\/jcpt.13665"],"URL":"https:\/\/doi.org\/10.1111\/jcpt.13665","archive":["Portico"],"relation":{},"ISSN":["0269-4727","1365-2710"],"issn-type":[{"value":"0269-4727","type":"print"},{"value":"1365-2710","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,9]]},"assertion":[{"value":"2022-01-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}