{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T08:39:37Z","timestamp":1753519177678},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,3,4]],"date-time":"2013-03-04T00:00:00Z","timestamp":1362355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>Recent studies have shown the association between blood pressure variability and cardiovascular events. The present study was designed to investigate the relationship between antihypertensive drug class and home blood pressure variability in patients with type\u00a02 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We compared home blood pressure variability among patients treated with calcium channel blockers (<jats:italic>n<\/jats:italic>\u00a0=\u00a044), with angiotensin\u00a0<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> receptor blockers and\/or angiotensin\u2010converting enzyme inhibitors (<jats:italic>n<\/jats:italic>\u00a0=\u00a0159), and with calcium channel blockers combined with angiotensin\u00a0<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> receptor blockers and\/or angiotensin\u2010converting enzyme inhibitors (<jats:italic>n<\/jats:italic>\u00a0=\u00a0183). Next, we analyzed the effect of calcium channel blockers on morning blood pressure variability using multiple linear regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Coefficient variation of morning systolic blood pressure in patients treated with calcium channel blockers was significantly lower than that in patients treated with angiotensin\u00a0<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> receptor blockers and\/or angiotensin\u2010converting enzyme inhibitors (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.036). Multivariate linear regression analyses showed that treatment with calcium channel blockers was significantly correlated with coefficient variation of morning systolic blood pressure (\u03b2<jats:italic>\u00a0<\/jats:italic>=\u00a0\u22120.264, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present study implies a possibility for validity on selecting calcium channel blockers in hypertensive patients with type\u00a02 diabetes to reduce home blood pressure variability.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.12052","type":"journal-article","created":{"date-parts":[[2013,3,4]],"date-time":"2013-03-04T22:31:16Z","timestamp":1362436276000},"page":"399-404","source":"Crossref","is-referenced-by-count":12,"title":["Beneficial effect of calcium channel blockers on home blood pressure variability in the morning in patients with type\u00a02 diabetes"],"prefix":"10.1111","volume":"4","author":[{"given":"Emi","family":"Ushigome","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Kyoto Prefectural University of Medicine Graduate School of Medical Science Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiaki","family":"Fukui","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Kyoto Prefectural University of Medicine Graduate School of Medical Science Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahide","family":"Hamaguchi","sequence":"additional","affiliation":[{"name":"Immunology Frontier Research Center at Osaka University Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Kyoto First Red Cross Hospital Kyoto 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