{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T09:32:46Z","timestamp":1725010366999},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,12,13]],"date-time":"2014-12-13T00:00:00Z","timestamp":1418428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Diabetes Masters Conference Research Grant of Japan Diabetes Fundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2015,7]]},"abstract":"Abstract<\/jats:title>Aims\/Introduction<\/jats:title>Circulating progenitor cells, including CD<\/jats:styled-content>34 positive (CD<\/jats:styled-content>34+<\/jats:sup>) cells, play a key role in neovascularisation and the maintenance of vascular endothelial function. Several lines of evidence show an association between decreased levels of circulating CD<\/jats:styled-content>34+<\/jats:sup> cells and cardiovascular disease. However, the contribution of circulating CD<\/jats:styled-content>34+<\/jats:sup> cells to the occurrence of cardiovascular events in diabetic patients remains unclear.<\/jats:p><\/jats:sec>Materials and Methods<\/jats:title>In the present study with a median follow up of 4.6\u00a0years, we analyzed the level of circulating CD<\/jats:styled-content>34+<\/jats:sup> cells in 192 patients with type\u00a02 diabetes. The outcome variables were coronary heart disease (CHD<\/jats:styled-content>) events (cardiovascular death, unstable angina, myocardial infarction, percutaneous coronary intervention or coronary artery bypass grafting) and cerebrovascular disease events (cerebral infarction, cerebral hemorrhage or transient ischemic attack).<\/jats:p><\/jats:sec>Results<\/jats:title>Decreased levels of circulating CD<\/jats:styled-content>34+<\/jats:sup> cells were associated with a significantly higher incidence of CHD<\/jats:styled-content> based on Kaplan\u2013Meier analysis (P<\/jats:italic>\u00a0=\u00a00.0052). After adjusting for age, sex, dyslipidemia, hypertension, glycated hemoglobin, history of cardiovascular disease, body mass index, and statin and renin angiotensin system inhibitors use, decreased levels of CD<\/jats:styled-content>34+<\/jats:sup> cells were significantly associated with the incidence of CHD<\/jats:styled-content> events (hazard ratio of low tertile 2.61, 95% confidence interval 1.22\u20135.96; P<\/jats:italic>\u00a0=\u00a00.013, reference; high tertile).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Decreased levels of circulating CD<\/jats:styled-content>34+<\/jats:sup> cells might predict CHD<\/jats:styled-content> events in patients with diabetes, and this could be useful for identifying patients with diabetes at high risk of cardiovascular events.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.12310","type":"journal-article","created":{"date-parts":[[2014,11,12]],"date-time":"2014-11-12T08:47:58Z","timestamp":1415782078000},"page":"473-478","source":"Crossref","is-referenced-by-count":19,"title":["Decreased levels of circulating CD<\/scp>34+<\/sup> cells are associated with coronary heart disease in Japanese patients with type 2 diabetes"],"prefix":"10.1111","volume":"6","author":[{"given":"Hisashi","family":"Makino","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism National Cerebral and Cardiovascular Center Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Division of Preventive Cardiology National Cerebral and Cardiovascular Center Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akie","family":"Kikuchi\u2010Taura","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory National Hospital Organization Osaka Minami Medical Center Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiro","family":"Soma","sequence":"additional","affiliation":[{"name":"Department of Hematology Hyogo College of Medicine Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Department of Regenerative Medicine Research Institute of Biomedical Research and Innovation Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro","family":"Kishimoto","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism National Cerebral and Cardiovascular Center Suita 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