{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:55:03Z","timestamp":1788191703747,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,6,11]],"date-time":"2015-06-11T00:00:00Z","timestamp":1433980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research program of China","doi-asserted-by":"crossref","award":["2013CB530803"],"award-info":[{"award-number":["2013CB530803"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research program of China","doi-asserted-by":"crossref","award":["2015CB553605"],"award-info":[{"award-number":["2015CB553605"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National High Technology R&D Program","award":["2012AA02A512"],"award-info":[{"award-number":["2012AA02A512"]}]},{"name":"Science & Technology Project of Beijing, China","award":["Z131100002613004"],"award-info":[{"award-number":["Z131100002613004"]}]},{"name":"Science & Technology Project of Beijing, China","award":["D131100004713003"],"award-info":[{"award-number":["D131100004713003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>There are sparse and limited studies on erythrocyte morphology in renal biopsy identifying nephropathic patients among type\u00a02 diabetics. The present study sought to clarify the predictive value of dysmorphic erythrocytes in type\u00a02 diabetics with non\u2010diabetic renal disease and influences on hematuria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We examined 198 patients with type\u00a02 diabetes who underwent kidney biopsies between 2012 and 2013. Hematuria was defined as &gt;3 or &gt;10 red blood cells per high\u2010power field (<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>s\/hpf) in urine sediment. If &gt;80% of the erythrocytes were dysmorphic, glomerular hematuria was diagnosed. Clinical findings and predictive value of dysmorphic erythrocytes were compared between patients with hematuria (<jats:italic>n<\/jats:italic>\u00a0=\u00a019) and those without (<jats:italic>n<\/jats:italic>\u00a0=\u00a061). The potential risk factors for hematuria among diabetic nephropathy patients were also screened.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a statistically significant difference between the diabetic nephropathy group and the non\u2010diabetic renal disease group (6.6 vs 16.8%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04) when the demarcation point of hematuria was 10\u00a0<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>s\/hpf. When the definition of hematuria was based on an examination of urinary erythrocyte morphology, a marked difference was seen (3.3 vs 24.8%; <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). Glomerular hematuria showed high specificity and a positive predictive value (0.97 and 0.94, respectively) in non\u2010diabetic renal disease. A multivariate analysis showed that nephrotic syndrome was significantly associated with hematuria (odds ratio 3.636; <jats:italic>P\u00a0<\/jats:italic>=\u00a00.034).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Dysmorphic erythrocytes were superior to hematuria for indicating non\u2010diabetic renal disease in type\u00a02 diabetics. Nephrotic syndrome was an independent risk factor for hematuria.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.12371","type":"journal-article","created":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T05:05:10Z","timestamp":1431407110000},"page":"115-120","source":"Crossref","is-referenced-by-count":25,"title":["Dysmorphic erythrocytes are superior to hematuria for indicating non\u2010diabetic renal disease in type\u00a02 diabetics"],"prefix":"10.1111","volume":"7","author":[{"given":"Zhe\u2010yi","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Nephrology Chinese PLA General Hospital Chinese PLA Institute of Nephrology State Key Laboratory of Kidney Diseases National Clinical Research Center of Kidney Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan\u2010da","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology Chinese PLA General Hospital Chinese PLA Institute of Nephrology State 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