{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T18:52:51Z","timestamp":1769107971621,"version":"3.49.0"},"reference-count":7,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,2,16]],"date-time":"2016-02-16T00:00:00Z","timestamp":1455580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the present study we examined the efficacy of sodium\u2010glucose cotransporter 2 inhibitors on improvement of glycated hemoglobin (HbA1c) in comparison with the renal threshold for glucose reabsorption in patients with type 2 diabetes mellitus. Patients visited the hospital once a month for a regular follow\u2010up examination with the determination of blood glucose and HbA1c levels, and urinary glucose concentration from spot urine samples. Patient samples were compared before and after ipragliflozin administration. We defined the renal threshold for glucose reabsorption as the lowest blood glucose level that correlated with the first detectable appearance of urine glucose. These data showed a significant negative correlation between improvement of HbA1c level and renal threshold for glucose reabsorption in patients treated with the sodium\u2010glucose cotransporter 2 inhibitor. These findings show that patients who have a higher renal threshold for glucose reabsorption can be expected to more effectively respond to sodium\u2010glucose cotransporter 2 inhibitor therapy in terms of lowering HbA1c levels.<\/jats:p>","DOI":"10.1111\/jdi.12473","type":"journal-article","created":{"date-parts":[[2016,1,10]],"date-time":"2016-01-10T10:03:30Z","timestamp":1452420210000},"page":"751-754","source":"Crossref","is-referenced-by-count":18,"title":["Renal threshold for glucose reabsorption predicts diabetes improvement by sodium\u2010glucose cotransporter 2 inhibitor therapy"],"prefix":"10.1111","volume":"7","author":[{"given":"Aya","family":"Osaki","sequence":"first","affiliation":[{"name":"Department of Medicine and Molecular Science Gunma University Graduate School of Medicine Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuichi","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Medicine and Molecular Science Gunma University Graduate School of Medicine Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsugumichi","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Medicine and Molecular Science Gunma University Graduate School of Medicine Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eijiro","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Medicine and Molecular Science Gunma University Graduate School of Medicine Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumeo","family":"Ono","sequence":"additional","affiliation":[{"name":"Ono\u2010naika Clinic Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yawara","family":"Niijima","sequence":"additional","affiliation":[{"name":"Kan\u2010etsu Chuo Hospital Takasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroto","family":"Hoshi","sequence":"additional","affiliation":[{"name":"Hoshi\u2010iin Maebashi Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanobu","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Medicine and Molecular Science Gunma University Graduate School of Medicine Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp140168"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(05)72953-2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.12.3427"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.4140.766"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-0387"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2014.38.4.261"},{"key":"e_1_2_7_8_1","first-page":"1","article-title":"Better response to the SGLT2 inhibitor dapagliflozin in young adults with type 2 diabetes","volume":"19","author":"Nakamura Y","year":"2015","journal-title":"Expert Opin Pharmacother"}],"container-title":["Journal of Diabetes Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdi.12473","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.12473","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdi.12473","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.12473","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T12:22:27Z","timestamp":1696249347000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdi.12473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,16]]},"references-count":7,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1111\/jdi.12473"],"URL":"https:\/\/doi.org\/10.1111\/jdi.12473","archive":["Portico"],"relation":{},"ISSN":["2040-1116","2040-1124"],"issn-type":[{"value":"2040-1116","type":"print"},{"value":"2040-1124","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,16]]}}}