{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T22:12:47Z","timestamp":1778969567428,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T00:00:00Z","timestamp":1456099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>To investigate the effect of pitavastatin on glucose control in patients with type 2 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Medical records of 340 patients with type 2 diabetes treated with pitavastatin or atorvastatin between 1 August 2013 and 31 May 2014 were reviewed. A total of 96 patients who had not received statins were treated with pitavastatin (N to P group). A total of 100 patients who had previously used atorvastatin were switched to pitavastatin (A to P group). A total of 144 patients continued with atorvastatin treatment. Data were collected at baseline, 3 and 6 months of treatment. Changes in glycated hemoglobin (HbA1c) level were analyzed in 222 patients who did not change their antidiabetic agent during 6 months of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A negative correlation between baseline HbA1c and delta HbA1c at 6 months was found in the pitavastatin\u2010treated patients (N to P group: \u03c1 = \u22120.329, <jats:italic>P<\/jats:italic> = 0.006; A to P group: \u03c1 = \u22120.480, <jats:italic>P<\/jats:italic> &lt; 0.001). The correlation remained similar after adjusting for age, body mass index, dose of pitavastatin, estimated glomerular filtration rate and high\u2010density lipoprotein cholesterol. After 6 months of treatment, the benefit of pitavastatin on HbA1c in the patients with poorly controlled diabetes was significant in both the N to P (8.1 vs 7.4%, <jats:italic>P<\/jats:italic> = 0.018) and A to P (9.7 vs 9.0%, <jats:italic>P<\/jats:italic> = 0.015) groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pitavastatin decreases HbA1c in patients with type 2 diabetes with a higher baseline HbA1c level. The benefit on HbA1c was also observed in patients with previous use of atorvastatin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.12483","type":"journal-article","created":{"date-parts":[[2016,1,18]],"date-time":"2016-01-18T13:43:29Z","timestamp":1453124609000},"page":"769-776","source":"Crossref","is-referenced-by-count":22,"title":["Pitavastatin improves glycated hemoglobin in patients with poorly controlled type 2 diabetes"],"prefix":"10.1111","volume":"7","author":[{"given":"Chung\u2010Huei","family":"Huang","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine Chang Gung Memorial Hospital, Chang Gung University Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Yao","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine Chang Gung Memorial Hospital, Chang Gung University Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brend Ray\u2010Sea","family":"Hsu","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine Chang Gung Memorial Hospital, Chang Gung University Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-10-1163"},{"key":"e_1_2_7_3_1","first-page":"449","article-title":"Statins, high\u2010density lipoprotein cholesterol, and regression of coronary atherosclerosis","volume":"297","author":"Nicholls SJ","year":"2007","journal-title":"JAMA"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.10.047"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f2610"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.860"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61965-6"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12076"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13340-011-0032-0"},{"key":"e_1_2_7_10_1","unstructured":"OdawaraM YamazakiT KishimotoJ et al.Pitavastatin for the delay or prevention of diabetes prevention in individuals with impaired glucose tolerance. 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